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🧵 Thread: What happens when transcription isn’t properly shut off during mitosis? Our new preprint explores just that 👇
biorxiv.org/content/10.648…
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Oliveira Lab
591 posts
Oliveira Lab
@CHR_lab
Chromosome Dynamics Lab @ Católica Biomedical Research. Aiming to understand how mitotic chromosomes are assembled and influence mitotic fidelity
Oeiras, Portugal Beigetreten Ekim 2015
416 Folgt1.5K Follower
Oliveira Lab retweetet
We are #hiring ! Our lab is looking for a LabTech/Lab Manager! Take a look to our research here!
physics-of-life.tu-dresden.de/team/pol-group…
Drop a line if you are interested to know more details and please share!
#labtech #biology #JobAlert #labmanager #labwork #Xenopus #zebrafish #devbiol #Science
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🧵 Thread: What happens when transcription isn’t properly shut off during mitosis? Our new preprint explores just that 👇
biorxiv.org/content/10.648…
English
5/ This means that mitotic transcription isn’t just a passive consequence of cell cycle stage — it actively threatens genome stability when not properly regulated.
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4/ The result? When transcription isn’t cleared, sister chromatid resolution is impaired — a critical step needed to ensure faithful chromosome segregation in anaphase.
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3/ Importantly, we show that these defects arise because R-loops form when transcription persists during mitosis — and preventing transcription reverts the defects. That establishes a causal link.
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2/ Using TTF2 depletion to force nascent transcripts to persist on mitotic chromatin, we found that this abnormal retention leads to mitotic errors including abnormal chromosomes and bridges.
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1/ During mitosis, cells globally suppress transcription as chromosomes condense — a conserved hallmark of cell division. But what if this repression fails? 😮💨
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Happy to be the next @CRGenomica director. The CRG always stood out to me for its excellence in decoding life’s principles & its collaborative, open and innovative way of doing science. Thrilled to follow L Serrano footsteps & join its amazing community!
crg.eu/en/news/monica…
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@ELogarinho Dream team!!! I am so sorry I could not make it!! I heard it was a blast!! I am already counting due to the next one (where will it be??)
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Uma conversa relaxada sobre como a infância marca os dias de hoje (e não só!) :) Grande Geração 80!!!
Expresso@expresso
Raquel Oliveira: “Há uns anos, o cancro era uma sentença de morte, só ouvir falar na palavra dava arrepios, e hoje em dia já não é assim” #Echobox=1745478250" target="_blank" rel="nofollow noopener">expresso.pt/podcasts/gerac…
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Oliveira Lab retweetet
The Vascular Biology & Disease Lab is recruiting one Postdoc to work on a fascinating project on blood vessels and sleeping sickness in collaboration with @luisamfigueired lab.
More info: tinyurl.com/2cta2898
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Common misspelling… I share the feeling 😂😂 (and no, we are not related… and yes, I very proud 🇵🇹🚴🏅)
Ravsieg - João P.@Ravsieg
Hey @eurosport @Olympics, misspelling Oliveira's name feels very disrespectful, any chance that's fixed for the podium ceremony?
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Oliveira Lab retweetet
Last days to apply: Looking for a technician to help with our exciting work understanding the retina from cells to tissue. Want some lab experience in a fun team on a great campus with opportunity to develop? Apply here: euraxess.ec.europa.eu/jobs/233872 DM me in case of questions!
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@osorio_ds Muito obrigada @osorio_ds !!! Sucessos, venham eles ;)
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Perfect way to celebrate the *12th anniversary* of the Chromosome Dynamics Lab. I am so proud to work with such amazing people (past and present!) 👏🥳🎉🥂
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@IGCcentrioles Muito obrigada Mónica!! E obrigada pela eterna ajuda e suporte ao longo destes anos!!
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@CytoLabKoc Congratulations Elif!! Welcome to the world Leyla!! 😍 ps: girls rock!!
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Our girl Leyla Nur arrived on June 27th, becoming our first F1 without a Y chromosome! I've finally gained a female ally at home and I'm excited about the new family dynamics.
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This must be the funniest media take on a work I have had a (minor) contribution to 😂😂😂
Paulo Navarro-Costa@germcells
Our story in collab with the labs of @DevoEvoMed, @DavidEnard, @FTuttelmann and @CHR_lab has been picked up by the British tabloids and the result has far exceeded even my most outlandish expectations 🤣🤣 dailymail.co.uk/sciencetech/ar…
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@IGCcentrioles Agora é revolucionar a coisa!!! No pressure 😉! Muitos parabéns!!! Merecido :) 👏👏👏
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Seminário de “entrada” - sócia correspondente- Academia das Ciências de Lisboa sobre a minha investigação - saúde humana e do planeta. Honra dupla pois falei a seguir a Filipe Duarte Santos. Não pude deixar de comentar que nao faz sentido a ACL ter tão poucas mulheres e jovens.
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