Cellular and Molecular Life Sciences

🚨 New from our team! CMLS Editors’ Choice Articles Targeting HIF-2α in glioblastoma reshapes the immune landscape and boosts response to immune checkpoint blockade. 📢 A promising strategy to overcome resistance in GBM immunotherapy. 🧠🔬 Read more: doi.org/10.1007/s00018…

🚨 New from our team! CMLS Editors’ Choice Articles 📢 Mutated Sigma-1R disrupts cell homeostasis in dHMN patient cells. 🧠 Pallafacchina et al reveal impaired ER-mitochondria dynamics + protein quality control. 📖 Read more: link.springer.com/article/10.100…

🚨 New from our team! CMLS Editors’ Choice Articles 📢 Systematic profiling of nuclear receptor expression in glioblastoma stem cells reveals subtype-specific therapeutic targets. 🧠 Important insights into GBM heterogeneity from Murek et al. 📖 link.springer.com/article/10.100…

🚨 New from our team! CMLS Editors’ Choice Articles 📢 3D spatial transcriptomics reveals how the GBM microenvironment evolves after chemoradiation. 🧠🔬Murek et al map tumor-host dynamics post-treatment - a leap toward personalized GBM therapy. 📖 link.springer.com/article/10.100…

R-spondins secreted by human pancreas-derived mesenchymal stromal cells support pancreatic organoid proliferation. Alessandro Cherubini, Clelia Pistoni, Maria Chiara Iachini, et al., link.springer.com/article/10.100… rdcu.be/egkLa

Nicotinamide metabolism reprogramming drives reversible senescence of glioblastoma cells. Ashwin Narayanan, Mirca S. Saurty-Seerunghen, Jessica Michieletto, et al., link.springer.com/article/10.100… rdcu.be/egkKt

PI(3,4,5)P3-mediated Cdc42 activation regulates macrophage podosome assembly. Yaoyue Qi, Cheng-han Yu. link.springer.com/article/10.100… rdcu.be/egkJD

The HBV large envelope protein initiates virion assembly by recruiting capsids at membrane rich domains related to late endosome. Florian Seigneuret, Sébastien Eymieux, Vanessa Sarabia-Vega, et al., link.springer.com/article/10.100… rdcu.be/egkIR

Spatiotemporal profiling of adhesion G protein-coupled receptors in developing mouse and human pancreas reveals a role for GPR56 in islet development. Oladapo E. Olaniru, Klaudia Toczyska, Nunzio Guccio, et al., link.springer.com/article/10.100… rdcu.be/egkIC

Endophilin B1 is essential for maintaining cardiac function by regulating mitocytosis. Jingyu Deng, Xiaoqian Chang, Xiaomeng Zhang, et al., link.springer.com/article/10.100… rdcu.be/egkIv

Microglia regulate myelin clearance and cholesterol metabolism after demyelination via interferon regulatory factor 5. Alejandro Montilla, Alazne Zabala, Ibai Calvo, et al., link.springer.com/article/10.100… rdcu.be/egkIp

METTL3-dependent m6A methylation of circCEACAM5 fuels pancreatic cancer progression through DKC1 activation. Jie Zhang, Wenxue Sun, Wenda Wu, Zihui Qin, Ben Wei, Tushuai Li link.springer.com/article/10.100… rdcu.be/egkHA

Correction: Histone demethylase KDM4A regulates adipogenic and osteogenic differentiation via epigenetic regulation of C/EBPα and canonical Wnt signaling link.springer.com/article/10.100… rdcu.be/egkHb

Dysregulated cholesterol uptake and efflux of bone marrow-derived α-SMA+macrophages contribute to atherosclerotic plaque formation. link.springer.com/article/10.100… rdcu.be/egkG0

Genome-wide profiling and functional characterization of circular RNAs in neural development and injury: insights from a rat model research. link.springer.com/article/10.100… rdcu.be/egkF6

Siglec-15 is a putative receptor for porcine epidemic diarrhea virus infection Zhihua Feng, Yajuan Fu, Sheng Yang, Heng Zhao, Minhua Lin, Chuancheng Liu, Weili Huang, Xinyan He, Yao Chen, Jianxin Chen, Yangkun Shen, Zhaolong Li, Qi Chen rdcu.be/egkE5

Metabolic flux analysis in hiPSC-CMs reveals insights into cardiac dysfunction in propionic acidemia rdcu.be/egkEX Eva Richard, Hannah Marchuk, Mar Álvarez, Wentao He, Xiaoxin Chen, Lourdes R. Desviat, Guo-Fang Zhang

link.springer.com/article/10.100… rdcu.be/egkEC Bocheng Han, Qiang Zheng, Huiling Li, Yongjun Wang, Dongshan Zhang

Cross-regulation of RNA methylation modifications and R-loops: from molecular mechanisms to clinical implications. link.springer.com/article/10.100…

Transcriptome and epigenome dynamics of the clonal heterogeneity of human induced pluripotent stem cells for cardiac differentiation. link.springer.com/article/10.100…