Cogstate

Placebo response rates in major depressive disorder (MDD) trials can reach as high as 30-40%, obscuring true treatment effects. Join us for a webinar on mitigating placebo response and enhancing signal detection in MDD clinical trials. Register here: buff.ly/sliN5KU

This JAMA Neurology article co-authored by Prof Paul Maruff features a recent P2 trial for adults with NT1, where treatment with the oral OX2R-selective agonist oveporexton resulted in significant improvements in attention, executive function, and memory. buff.ly/3c6SxTf

Svenja Wacker, PhD (Neuropsychology Science Director) presented data at the 2025 ISCTM Spring Conference showcasing the strengths of the Cogstate Brief Battery as a valid option for remote, self-administered cognitive testing via smartphone. Learn more: buff.ly/juxSbOg

The CDR scale's ability to detect meaningful change depends on rater expertise, rigorous training, and careful protocol planning. Our latest blog explores practical strategies to increase signal detection and ensure reliable outcomes in your AD studies. buff.ly/EA3sO8u

For decades, the ADAS-Cog has been considered a gold standard in Alzheimer’s disease clinical trials. However, this legacy tool has limitations; explore insights from our science team about advantages and challenges of the ADAS-Cog in our newest blog: buff.ly/pFXYoEQ

Based on decades of AD trial experience, Cogstate scientists have compiled rating scale insights to create the Alzheimer’s Disease Clinical Trial Endpoint Guide. Review considerations around the most widely used scales in AD drug development here: buff.ly/Uf2pfeb

Join us for a webinar with expert Pam Ventola, PhD, as she shares proven tactics and clinical trial case examples of how rare disease study teams are improving clinical response signaling using targeted approaches to endpoint data quality. Register here: buff.ly/TapxSoa

At SLEEP 2025, a meta-analysis of 77 trials was presented, confirming the PVT’s sensitivity to cognitive impairment and change, and offering a strong foundation for its use in evaluating new treatments for sleep-wake disorders. View the poster 👉buff.ly/17ANSjG

We’re delighted to announce the addition of the Objective Retention-based Cognitive Assessment (ORCA) suite of learning tests to our platform, allowing learning to be assessed and analyzed with rigor, precision, and accuracy. Experience the demo at booth #1610 during #AAIC25!

New findings presented at SLEEP 2025 underscore the importance of incorporating cognitive symptoms into both the clinical understanding of Narcolepsy Type 1 (NT1) and the development of targeted treatments (Harel, 2025). View the poster 👉 buff.ly/3LX8neY

25 Days to #AAIC25! Cogstate is back at the world’s leading Alzheimer’s conference and proud to present new science that supports better decision-making in Alzheimer’s drug development. See the full list of presentations: cogstate.com/aaic-2025/

At Cogstate, reconciliation is more than a conversation—it's part of our foundation. In 1999, our journey began while working alongside Indigenous communities in Central Australia. Now, we reaffirm our commitment to building a future rooted in respect, equity, and understanding.

Are you enrolling the right participants in Alzheimer’s trials? Reliable screening is vital for identifying cognitive impairment. Using Cogstate digital tests can enhance outcomes. Read the literature summary here > cogstate.com/fact-sheet/lit…

Kaycee Sink, MD, MAS, recently joined Cogstate as CMO, sharing her AD expertise in research, pharma dev, & patient care. Watch her chat w/ Brad O’Connor on trial design, biomarkers, recruitment & early AD intervention: youtube.com/watch?v=0USoiB…

Recent study results utilizing Cogstate digital tests provide a strong foundation for further development of M1 drugs and note the potential for cognitive enhancement in PD and other neurodegenerative disorders. 📕 Read the full paper here: jamanetwork.com/journals/jaman…

Working in rare epilepsy disorders? 🧬 Join us on Oct 3 to learn how to help your team: ▪️ Collect data across large geographic areas ▪️ Approach locations that don't have specialized raters ▪️ Select cognitive & behavioral endpoints 🗓️ Register here: xtalks.com/webinars/devel…

In this short whitepaper, Prof. Paul Maruff uses case examples from clinical trials we’ve supported to explore insights and methodologies that can help clinical trial teams improve decision-making in this area: cogstate.com/fact-sheet/enh…

Can the sedative effects of drugs like benzodiazepines observed in healthy young adults help estimate their impact on older adults? Cogstate CIO, Paul Maruff, answers questions about this topic & more in this short video👉 youtu.be/g0gZf7annhQ

🧠 📱 Check out updates about Lila from our Science Director, Svenja Wacker, and discover how Lila could impact not only clinical trials and healthcare settings, but also empower consumers to track their own cognitive health over time: youtu.be/oigY-SQaQiE

🌎 51,398 people are participating in AD clinical trials worldwide. This statistic & others from a recent report published in the journal Alzheimer's & Dementia highlight the scope of the current AD drug development landscape. Find more statistics here 👉 cogstate.com/blog/advanceme…