@SouthCambs Just to let you know the staff collecting blue bins in Cherry Hinton area this morning are clearly not aware of this service.
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Dean Clift
25 posts
🔋🔋 South Cambridgeshire households can now conveniently recycle used, small batteries weekly
🔋🔋 Just put used batteries inside a small plastic bag, tie it up, and leave it top of any wheelie bin when you put it out
🔋🔋 scambs.gov.uk/more-frequent-…
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Dean Clift retweetet
Latest #Biorxiv paper from our lab looks at how Trim7 interacts with its substrates to explain the diverse roles described for this E3 ligase. Following is a short thread summarising the findings (1) biorxiv.org/content/10.110…… pic.twitter.com/Izb86yuqSd
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Dean Clift retweetet
Fresh preprint from the lab on TRIM21 mechanism. More info in @LeoKiss5 tweetorial here:
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Dean Clift retweetet
Linking optogenetic clustering to degradation and what it tells us about TRIM21 activation. This and much more in this work by @Deanclift1 Leo James @w_mcewan and many collaborators, including Filipa Santos and @MarianaOsswald @i3S_UPorto
Dean Clift@DeanClift1
In @NatureSMB we show how #TrimAway technology works! #TRIM21 molecules must cluster at the target to degrade; #SocialDistancing not good! Embracing this clustering mechanism allows selective degradation of disease proteins, optogenetic Trim-Away & more! nature.com/articles/s4159…
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In @NatureSMB we show how #TrimAway technology works! #TRIM21 molecules must cluster at the target to degrade; #SocialDistancing not good! Embracing this clustering mechanism allows selective degradation of disease proteins, optogenetic Trim-Away & more! nature.com/articles/s4159…
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@LeoKiss5 @NatureComms All those scientific discussions across the table tennis table paid off! Imagine the science we can produce when we are allowed back in the pubs!!
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Dean Clift retweetet
Have you seen us in the paper today? Well done to Mrs Walsh for all her hard work setting up Forest School. Y1 have 💕 their session, Y2 next half term 😁
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A really clever assay here by @Gui_Pap to quantify cell-cell fusion mediated by SARS-CoV-2 spike protein in real time. Led to some interesting findings.... biorxiv.org/content/10.110…
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I would recommend this 5 minute read for an introduction to the cytosolic antibody receptor and E3 ubiquiting ligase #TRIM21
Jingwei@Jingwei_Zeng1
A Brief introduction to my PhD topic. #PLOSPathogens: Intracellular antibody immunity and its applications dx.plos.org/10.1371/journa…
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Dean Clift retweetet
De novo design of picomolar SARS-CoV-2 miniprotein inhibitors biorxiv.org/cgi/content/sh… #bioRxiv
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@RossHillScience Turns out it was @NevesOnTheFly with the wit. Although surely the last thing Arnie wants to do is degrade protein!? twitter.com/nevesonthefly/…
Alexandre Neves 🇧🇷🇵🇹🇺🇸🇪🇺@NevesOnTheFly
I would've picked Triminator rather than Trim-Away but this is still really cool! A Method for the Acute and Rapid Degradation of Endogenous Proteins cell.com/cell/fulltext/…
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#TrimAway. When we published this approach back in 2017, including binder-Fc fusion proteins, someone suggested the name ‘The Triminator’. Is TRIM21 the Arnold Schwarzenegger of proteins?
bioRxiv@biorxivpreprint
Predator: A novel method for targeted protein degradation biorxiv.org/cgi/content/sh… #bioRxiv
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Dean Clift retweetet
Engineered ACE2 receptor traps potently neutralize SARS-CoV-2 biorxiv.org/cgi/content/sh… #bioRxiv
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