Eric Smith

276 posts

Eric Smith

@ESmithMDPhD

Cell/Gene/mRNA engineering to cure cancer @DanaFarber, @harvardmed, @broadinstitute, formerly @sloan_kettering, #CART, recruiting extraordinary post-docs

Boston, MA Beigetreten Kasım 2014

900 Folgt1.5K Follower

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Eric Smith@ESmithMDPhD·29 Eyl

Our report of first-in-human GPRC5D-targeted CAR T cells for MM is out in NEJM! The trial was led by Sham Mailankody and could not be done without the amazing clinical, correlative science, stats, & cell manufacturing teams. Happy to share our bench>bedside journey 1/10

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Klebanoff_Lab@KlebanoffLab·27 Mar

🚨Today in @Cancer_Cell: 50,000 tumor genomes via MSK-IMPACT. We map which HLA alleles are highest yield for antigen discovery—and define when HLA LOH constrains targetability. A framework for scaling TCR therapies. @MSKCancerCenter @parkerici authors.elsevier.com/sd/article/S15…

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Eric Smith@ESmithMDPhD·17 May

@KlebanoffLab Thanks Chris!!

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Klebanoff_Lab@KlebanoffLab·17 May

Bravo Eric 🧬🙌!

Dana-Farber News@DanaFarberNews

Congratulations to Eric Smith, MD, PhD, @DanaFarber on receiving the Outstanding New Investigator Award from @ASGCTherapy. Smith will present on advancing CAR T cell therapy for cancer immunotherapy. #ASGCT2025

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Eric Smith@ESmithMDPhD·16 May

Honored to be recognized w/ past + current Investigators @AhrensNicklas @AnguelaXavier & @DevermanLab. Award is to our entire @DanaFarber gene and cell therapy team & the huge teams of colleagues past/present who work to bring these therapies from ideas in the lab to patients.

Dana-Farber News@DanaFarberNews

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Dana-Farber News@DanaFarberNews·16 May

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Eric Smith@ESmithMDPhD·16 May

Amazing work Ko-Wei Liu and the collaborative team to engineer CAR T cells where persistence is controlled by leveraging ⁦@CueBiopharma⁩ recombinant ImmunoSTATs to specifically deliver TCR+cytokine signals to our engineered cells. #asgct25 #asgct2025 ⁦@DanaFarberNews⁩

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Eric Smith@ESmithMDPhD·16 May

Congrats ⁦@EJBrea⁩ on awesome work and an awesome presentation showing how CAR T cell therapy can overcome ADC resistance in solid tumors and engineering rational biparatopic CARs. #asgct2025 #asgct25 ⁦@DanaFarberNews⁩

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Eric Smith@ESmithMDPhD·16 May

Congrats ⁦@LizCarstensMD⁩ on your outstanding presentation on engineering novel CARs to enhance the therapeutic window of CAR T cells for GI malignancies. #asgct2025 #asgct25 ⁦@DanaFarberNews⁩

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Eric Smith@ESmithMDPhD·13 Oca

Participated recently in the @WhiteHouse Cell & Gene Therapy Forum. Patient advocates, rare disease families were inspiring. Massive science advances (CAR T, sickle cell GT). Need to ensure ACCESS. Scientific AND policy solutions must be prioritized. #WhiteHouseCGT h/t @KamalMe.

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Eric Smith@ESmithMDPhD·14 Haz

Join me as I present with @Karl_Petri, @H_Einsele, and Chiara Bonini. Starting soon. #EHA24

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Eric Smith@ESmithMDPhD·13 Haz

Congrats to CAR T pioneers for work done @MSKCancerCenter (where I was lucky enough to get my start): @BrentjensRenier, Michel Sadelain, as well as @carlhjune (@pennmed) and Zelig Eshhar (@WeizmannScience) on winning the 2024 Warren Alpert Prize for CAR T cell tx! Well deserved!

Harvard Medical School@harvardmed

The 2024 Warren Alpert Prize honors four pioneers in CAR T-cell therapy bit.ly/3KCiSlw

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Eric Smith@ESmithMDPhD·4 May

Thanks @robin_shattock for bringing this to our attention. There is no evidence that mRNA vaccines cause cancer and these claims should not be a hurdle to progress with RNA technology being developed to benefit our patients.

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Eric Smith@ESmithMDPhD·26 Nis

Amazing being part of @IOTNmoonshot thank you to all who made this incredible network possible.

Cancer Immunoprevention Network@NCI_CIPNet

Co-Chairs Drs. Catherine Bollard and Eric Smith @ESmithMDPhD expressed heartfelt gratitude to all members for their enthusiasm and contributions. Thank you all for your support, and we eagerly anticipate seeing you at the capstone meeting in May!

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Eric Smith@ESmithMDPhD·10 Ara

Since it has come up in discussions a lot at #ash23, my thoughts on FDA investigation of secondary T cell malignancies post-CAR T can be found @TheLancetOncol: thelancet.com/journals/lanon… and in more detail: news.harvard.edu/gazette/story/… tldr:benefits>>>risks @MarcoRuella @DrMiguelPerales

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Luciano J Costa@End_myeloma·10 Ara

Very high activity with little disgeusia and skin toxicity. CAR-T may be the best way to hit GPRC5D. Terrific presentation by ⁦@SusanBal9⁩ #ASH23 ⁦@BerdejaJesus⁩ ⁦@ldandersonjr⁩ ⁦@OmarNadeemMD⁩

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Fyodor Urnov@UrnovFyodor·9 Ara

Gene editing for hemophilia: gorgeous data from @intelliatx @Regeneron #ASH23. Next-generation #CRISPR-based approach leveraging advances in liver editing! Robust advantages over conventional AAV. On a path to clinical trial initiation. 1. Woo. 2. Hoo! ash.confex.com/ash/2023/webpr…

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Muzaffar Qazilbash@Transplant_Doc·23 Kas

#ASH23 BMS-986393, GPRC5D–CAR-T for RRMM. N=70, ORR; 86%, 75% with prior BCMA-directed Rx. Skin/nail AE: 40%, dysgeusia: 3% @SusanBal9 @OmarNadeemMD @ldandersonjr #mmsm #bmtsm ash.confex.com/ash/2023/webpr…

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Eric Smith@ESmithMDPhD·10 Ara

Amazing presentation @SusanBal9. Kudos to PIs, clinical teams, and @bmsnews team. So excited to see the high response rate, ongoing responses, and low infectious rate with our GPRC5D CAR; many with prior BCMA tx. #mmsm #ash23 @OmarNadeemMD @BerdejaJesus @TomBmt133 @DanaFarberNews