Ghost Foot

Arizona: I’m running for re-election. Your stories of hard work, hope, and determination inspire me to keep moving our state forward. I’m ready to serve you for 4 more years and always put your family first. Let’s get to work.

@GovernorHobbs "Conspiracies"

Arizonans are tired of election conspiracies and lies that undermine our democracy. Arizona’s elections are free, fair, and secure, which numerous lawsuits and even the Arizona Senate’s “audit” into the 2020 election results have confirmed. The FBI’s reckless actions are an attack on Arizonans and undermine our rights as voters. I protected our democracy as Secretary of State, and I will always stand up against election deniers and fight to protect the integrity of Arizona’s elections.

@GovernorHobbs In other words "if we can't cheat, we can't win."

Only citizens vote in Arizona elections. That's the law and we'll continue to enforce it. We don't need Washington politicians telling us how to run our elections. This Executive Order is nothing more than an illegal attack on vote by mail and access to the ballot box.

@nicknorwitz open.substack.com/pub/ericmichae…

@nicknorwitz Even if the results are repeated across multiple populations, total cholesterol of ~230 is the sweet spot for ACM is strongly supported by numerous studies. You're trading a 3% risk reduction of death by CVD for an INCREASED risk of death of literally everything else

There’s been a lot of engagement and curiosity around the new Ez-PAVE results for intensive lipid lowering. Here are a few observations and some questions worth asking. First, the headline: intensive lipid-lowering therapy led to a 33% relative risk reduction (HR 0.67) and, more notably, a 3.1% absolute risk reduction in major adverse cardiovascular events (MACE)—including cardiovascular death, heart attack, stroke, revascularization, and hospitalization for unstable angina—over three years. Pause there. If that effect is real, it’s impressive. But it also raises some important questions. 1. How much of this effect is actually attributable to LDL lowering? The difference in LDL between groups was modest: a median of 56 mg/dL vs. 66 mg/dL. A ~10 mg/dL delta leading to a >3% absolute reduction in MACE over three years is a large effect size—and not one that feels immediately biologically intuitive. Is there a threshold effect at play? Something nonlinear about risk reduction at lower LDL levels? Or are we seeing effects beyond LDL itself? 2. Is there something unique about the population? This was a South Korean cohort. Could there be population-specific factors—genetic, environmental, or metabolic—that make individuals more responsive to modest lipid reductions or to the pleiotropic effects of the therapies used? 3. Who actually benefited? One under-discussed point: the benefit appears to be driven almost entirely by men. There was no clear evidence of benefit in female participants (HR 1.22) Yes, the cohort was male-skewed—but if you look at the hazard ratios, the signal is coming from men. That raises an important caution: these results may be prematurely generalized to populations (particularly women) where the data simply don’t support it. At present, the strongest evidence here applies to South Korean men. Question: Does the effect generalize? 4. What about the therapies themselves? “Intensive lipid lowering” wasn’t a single intervention—it included a spectrum of medications, each with distinct mechanisms and potential off-target effects. All of these should be considered for management of any individual patient… obviously. This includes off-target “good” effects, and off-target “bad” effects. As one case in point of additional “good” effects, take ezetimibe. Early data suggest potential neuroprotective benefits entirely independent of lipid management. I'm choosing to highlight a examples of a non-lipid pleiotropic "good" effect so no one can accuse me of 'cherry-picking,' but the point remains: this is more than a "lower LDL is better" story. It always was. It always will be. It’s sad, honestly, that when data like these come out the gut reaction is to shallowly wave a “lower is better” flag and attack the “LDL deniers” and “keto-zealots” in the name of virtue-signaling evidence-based medicine. It’s almost cultish behavior. In many cases, the shallowness of commentary reveals an almost intentional ignorance or, at minimum, a deficit in curiosity of what's actually going on in different human populations. Bottom line: These are interesting and potentially important data. They deserve thoughtful discussion—not dismissal. But simply waving the flag of “lower is better” isn’t a sufficient or rigorous interpretation of what’s actually going on here. We should be asking better questions. @realDaveFeldman @ApoDudz @AdrianSotoMota

What this article tries to present as "human behavior" is actually human FEMALE behavior. Men don't withhold affection as a punishment strategy. That's exclusively the behavior of women. geediting.com/j-a-y-psycholo…

Greasy @GavinNewsom can't answer a straightforward question. He tries fast talking his way out, but we see you Governor Hair Gel.

@RupertLowe10 How's that diversity working out for the UK? Somewhere in between Malaysia and South Africa it seems.

A statement from the Rape Gang Inquiry.

@PlayerStormy 🤣🤣🤣

The Canadian flag is flying at half mast today after losing the Olympic Gold Medal to the United States in hockey today

If you only watched @NBCSports coverage of the winter Olympics, you would think the US didn't even send any men this year... All they're showing is women's curling and those birds are in like 6th place.

@joeroganhq It ain't over till the fat lady sings.

This made me feel uncomfortable.

@boriquagato Import the third world, become the third world.

this seems a bit of an unfair comparison as it compares an urban area to a whole country. a more apt comparison might be paris vs warsaw. after running that analysis, the point still stands that paris has become far more dangerous than comparable polish cities. the gap is no longer as large, but still remains highly significant. i added another couple of categories (assault and rape) and we see the same pattern of "multiples higher" there.

@CAgovernor That way the cartels have an easier time finishing their hits? You're the worst. No amount of hair gel can make you human you lizard man.

Donald Trump's federal agents should be unmasked and identifiable. Period, full stop.

@Rightanglenews When immigrants demand you assimilate to THEIR culture, instead assimilating to YOURS, that's a sign you're being CONQUERED.

@Rightanglenews Unreal.

BREAKING - UK police are now telling dog owners where they can walk their pets, stating dogs are offensive to the Muslim population, with this woman ordered off her own street because Muslims were protesting nearby.

@joeroganhq WTF is going on with his eyes? He looks like he's medicated to the gills.

Mark Ruffalo suggests America should shift away from capitalism: "It’s gonna take some re-imagining of what America is."

How's all that "diversity" working out for the UK you might ask?

A Valentine's for your MAGA sweetheart! 🤣

Grateful to MAHA Center for allowing me to be part of this movement. @MAHA_Action