Jonathon Ditlev

Fantastic new preprint from @lesloew!!

Check our our new preprint. Combining measured solution rate constants and structural data to estimate bimolecular rate constants at membranes. biorxiv.org/content/10.110…

Together our results allowed us to develop a novel model for how shank2 controls RNA translation. We propose that mutations in shank2, like those in our study, result in dysregulated condensate physical properties, composition, and function to cause observed disease phenotypes.

In neurons with one copy of wild-type SHANK2 and a truncated SHANK2, we show that FMRP is mislocalized away from shank2 condensates, the ratio of phospho-FMRP to FMRP is increased, and expression of FMRP-targeted CaMKII is decreased, as predicted by our model.

Preprint alert from the @Jonathon_Ditlev Lab! In this study led by postdoctoral fellow Leshani Liyanage, we discovered that missense mutations in the IDR of shank2 results in increased condensate elasticity and altered composition and function. biorxiv.org/content/10.110…

#SKResearch from @Jonathon_Ditlev is helping scientists predict phase separations in complex cellular systems. Understanding atypical phase separations, which lead to the development of #cancer and neurological conditions, could inform new drug targets for these conditions.⬇️

@ATsabareesan Well done! Congratulations!

After a long journey, I am thrilled to announce that my first author postdoc paper, is finally published! nature.com/articles/s4155…

In this article, we compare simulations and in-vitro experiments to show that Solubility product is a good proxy to identify the phase transition threshold for heterotypic condensates. Wonderful collab between @lesloew and @Jonathon_Ditlev @CompCellBio

In this study in MBoC, @AniChattaraj and Zeynep Baltaci spearhead our efforts (w/ @lesloew & Bruce Mayer) to develop methods to quantitatively understand and predict phase separation of multivalent binding partners using computational modeling and precise quantitative microscopy

@CellfOrganized Wonderful news! Congrats!

Tenured. Thankful. Look out.

Led by @yimeiwan together with Jordyn Smith, Rhea Hudson, and Julie Forman-Kay, we investigate the biophysical mechanism for CFTR cluster formation on membranes. We find that clusters of CFTR are consistent with phase separated condensates. biorxiv.org/content/10.110…

Congrats to former postdoc Felix Keber from our & @MartinWuhr lab on this fascinating paper using filtration experiments w mass spec to show that ubiquitous mesoscale condensate formation across >18% of the proteome. rdcu.be/dzXsA

@jerelleaj @ZenoResearch Thank you for sharing your research with the #IDPSubgroup @jerelleaj!! And another thanks for chairing the Condensates: Physical Properties and Modeling session - it was a pleasure sharing a story from my group!

#bps2024 was definitely one for the books!! Thanks to @ZenoResearch and @Jonathon_Ditlev for the opportunity to present our work at #IDPSubgroup symposium!! What a wonderful symposium!!!

Hi everyone. We were made aware that many people were unable to book tickets yesterday. BPS have fixed the issue and extended our deadline - so please try again today. There are still some tickets left.

This will be an excellent symposium! Thank you @stromgaardlab for organizing it and for the invitation to share our work!

Today is the deadline to sign up for the IDP subgroup dinner!