Karreth Lab
1.2K posts
Karreth Lab
@KarrethLab
The Karreth Lab: non-mutational drivers, melanoma progression, mouse models at the Moffitt Cancer Center. Account maintained by Florian. Tweets are his views.
Beigetreten Nisan 2018
739 Folgt1.9K Follower
Grateful to @ASBMB for this extraordinary honor and to the colleagues who nominated me. This recognition means a great deal because it affirms something I believe deeply: talent is universal, but access is not.
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Karreth Lab retweetet
A special thanks to Board Chair, Doug Brodman and his wife, Terry, for hosting their fifth fundraiser in Naples, Florida. Since its inception, this event has raised more than $300,000 to support young melanoma investigators—fueling breakthroughs from the discovery of a promising immune cell linked to improved patient outcomes to the development of a clinical trial enhancing TIL therapy for advanced melanoma.
Florian Karreth, PhD (@KarrethLab), MRF research grant recipient and researcher from @MoffittNews shared updates on the impact of basic science research and the profound impact that early funding of innovative science has on long term outcomes for melanoma patients.
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We also detected disseminated UM cells in the liver, making this a great model to study UM dormancy and metastasis
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Using this model, we identified two main UM cell states, melanocytic and neural crest-like, that may be associated with growth vs metastasis.
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Very excited that our new mouse model of #uveal #melanoma is now published at @CR_AACR. This model recapitulates the genetics and biology of human UM progression and will be a powerful tool for preclinical UM research.
Cancer Research@CR_AACR
Now online: A Multi-Step Immune-Competent Genetically Engineered Mouse Model Reveals Phenotypic Plasticity in Uveal Melanoma doi.org/10.1158/0008-5…
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Karreth Lab retweetet
🚨🚨🚨Only 3 days left to apply for this incredible opportunity and to be considered for a nomination for the highly prestigious USF Presidential Doctoral Fellowship. #graduateschool #cancerresearch #phd
Moffitt Cancer Center@MoffittNews
Advance your career in #CancerResearch with the Moffitt Cancer PhD program! Application deadline: December 1, 2025 Are you passionate about fighting cancer? Our program prepares future scientists with a rigorous curriculum and offers four unique majors: • Cancer Biology • Cancer Chemical Biology • Cancer Immunology & Immunotherapy • Integrated Mathematical Oncology Why Moffitt? • Access to top research facilities • Collaborate with world-leading scientists • Hands-on experience in cutting-edge research • Supportive environment for innovation • Unmatched translational environment, turning discoveries into cures Start your journey to make a difference in cancer care and innovation. Learn more and apply now: bit.ly/3YH7yfH
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Lead by Xiaonan Xu, our paper describing Fra1 as a driver of #melanoma #metastasis is now published in Oncogene
nature.com/articles/s4138…
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Join our PhD program at Moffitt Cancer Center. We provide a world-class education in cancer biology, offer exquisite research infrastructure, and have fantastic labs and a wonderfully collaborative environment. And we are growing, i.e., offers will not be rescinded!
Moffitt Cancer Center@MoffittNews
Advance your career in #CancerResearch with the Moffitt Cancer PhD program! Application deadline: December 1, 2025 Are you passionate about fighting cancer? Our program prepares future scientists with a rigorous curriculum and offers four unique majors: • Cancer Biology • Cancer Chemical Biology • Cancer Immunology & Immunotherapy • Integrated Mathematical Oncology Why Moffitt? • Access to top research facilities • Collaborate with world-leading scientists • Hands-on experience in cutting-edge research • Supportive environment for innovation • Unmatched translational environment, turning discoveries into cures Start your journey to make a difference in cancer care and innovation. Learn more and apply now: bit.ly/3YH7yfH
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Karreth Lab retweetet
Researchers at Moffitt Cancer Center have been awarded a $22.4 million grant from the U.S. Department of War to lead groundbreaking studies and clinical trials for leptomeningeal disease. @moffittnews @moffittresearch newswise.com/articles/moffi…
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From the biology of melanocytes to pigmentation conditions and melanoma - we have it all! Join us in Tampa in March 2026 (great time to escape the cold) for the Annual Meeting of the @PASPCR1
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Interested in antisense #RNA and their contributions to #melanoma formation? Check out our latest paper: CDH3-AS1 antisense RNA enhances P-cadherin translation and acts as a tumor suppressor in melanoma: Cell Reports cell.com/cell-reports/f…
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This was fun to write and will be a useful resource for the melanoma field
Gennie Parkman@GennieParkman
Very proud to share our new review summarizing advances in understanding PTEN regulation and highlights its multifaceted role in suppressing melanomagenesis. Thank you to the best co-authors, @KarrethLab, @HolmenSheri, and Xiaonan Xu! pubmed.ncbi.nlm.nih.gov/40976930
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Well deserved recognition for @NicolMecozzi who also was recently awarded a @theNCI F99 grant
NicolMecozzi@NicolMecozzi
Grateful for it, thank you! @CancerBiol_PhD @USouthFlorida @KarrethLab
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Another preprint from our group, this one describing how the transcription factor FRA1 promoted #melanoma metastasis
bioRxiv Cancer Bio@biorxiv_cancer
FRA1 drives melanoma metastasis through an actionable transcriptional network biorxiv.org/content/10.110… #biorxiv_cancer
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Karreth Lab retweetet
Had a great time today touring the future Moffitt Discovery & Innovation Center! Excited for this new chapter for our Basic Science Division @MoffittNews lead by the amazing @LabElsaFlores
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Check out this powerful new uveal melanoma model from the amazing @KarrethLab and crew. Congrats on getting this out!
Karreth Lab@KarrethLab
Preprint alert: check out our new genetically engineered mouse model of uveal melanoma, which recapitulates many aspects of the human disease including phenotypic plasticity
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Preprint alert: check out our new genetically engineered mouse model of uveal melanoma, which recapitulates many aspects of the human disease including phenotypic plasticity
bioRxiv Cancer Bio@biorxiv_cancer
A multi-step immune-competent genetic mouse model reveals phenotypic plasticity in uveal melanoma biorxiv.org/content/10.110… #biorxiv_cancer
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Karreth Lab retweetet
Live from #AACR25: Kaizhen Wang (@Kaizhen20) from the @KarrethLab discusses how MYBL2 drives melanoma through a surprising mechanism, non-canonical RNA binding. This newly uncovered function reveals how MYBL2 reshapes gene regulation and promotes tumor growth, offering fresh insight into melanoma progression.
Key insights:
•MYBL2 is pregulated and plays an oncogenic role in melanoma while represents a melanoma vulnerability
• MYBL2 binds RNA in melanoma but not in melanocytes, and it promotes melanoma growth through its RNA binding function.
• RNA binding of MYBL2 enhances its association with chromatin and drives a transcriptional program which associated with poor patient outcomes.
• Distinct melanoma RNA background is the main determinant to enable MYBL2 RNA binding in melanoma cells
Read more: bit.ly/4cSt6eP
#MoffittAACR25
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Karreth Lab retweetet
While at #AACR25, Kaizhen Wang (@Kaizhen20) from the @KarrethLab shares new insights on melanoma progression, revealing how non-canonical RNA binding by the MYBL2 transcription factor plays a key role in driving the disease.
Read more: bit.ly/4cSt6eP
#MoffittAACR25
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