

The Klco Lab
65 posts

@KlcoLab
The Klco lab at @stjuderesearch - Defining the molecular and biological causes of pediatric myeloid tumors


























#Cover: Samd9l mutant mice recapitulate phenotypes seen in pediatric myelodysplastic syndromes: buff.ly/3zoHdGm Image: non-random chromosomal deletions of the mutant Samd9l locus in the mouse model; Credit: Virginia Valentine & Marcus Valentine @KlcoLab @StJudeResearch



Reanalysis of 553 pediatric #AML #WTS led to the identification of a new AML subtype with recurrent 9bp insertions in exon 3 of CBFB. The GEP of cases with CBFBins was similar to CBFB::MYH11 AML but had a more stem-like signature (BCL2L14, MEIS1, HOXA). doi.org/10.1182/blood.…