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Nix 🍀

@KryptyPop

Deep value bio investor. KryptyPop and my wife Julia. 35 yr Financial Advisor. Christian. Music lover and part time bull shitter. Dog lover.

Lake Dallas, TX Beigetreten Ekim 2021
4.3K Folgt1.3K Follower
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Nix 🍀
Nix 🍀@KryptyPop·
@Boomchrisy Freeze the tumor. No pectin. $NWBO killing cancers DCVAX-L
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Matt Van Swol
Matt Van Swol@mattvanswol·
🚨HOLY CRAP!!! ICE has just confirmed that it ARRESTED THE EMPLOYERS of 48 illegal immigrants in South Carolina!!! Both the Plant Manager and HR Coordinator for a casting company in Abbeville SC were ARRESTED and face years in prison. IS THIS WHAT YOU VOTED FOR?!!!!!
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C3
C3@C_3C_3·
Spencer Pratt got 0 out of 24,000 votes in a late night LA ballot drop. 0/24,000 A guy getting around 30% support got 0 out of 24,000. Astronomically small probability of happening. Impossible. California no longer even hides it. Doors need to be kicked in.
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Jonathan Mariande
Jonathan Mariande@jonathnmariande·
@MarioNawfal Voter ID and proof of citizenship are not radical positions. They are basic legitimacy checks. When 80% of the country supports something this obvious and Washington still kills it, people are not being paranoid when they say the system is protecting itself.
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Stephanie 🇬🇧🇺🇸🦍
🤣🤣GASBAGPARINO CAN SHARE A CELL WITH ANDREW LEFT 🤣🤣
Stephanie 🇬🇧🇺🇸🦍 tweet media
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Mila Joy
Mila Joy@Milajoy·
PROOF OF CHEATING IN CALIFORNIA. Notice that Karen Bass and Nithya Raman each increased by about 10,000 votes, but Spencer Pratts number stayed the EXACT SAME. So, in over 20K votes cast, Spencer didn't get ONE. This is IMPOSSIBLE. The fix is surely in.
Mila Joy tweet media
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piercheney
piercheney@LVpolitic·
I’m not a big election fraud guy - but the 24,000 ballot drop showing Spencer Pratt didn’t receive a single vote, is just not realistically possible. Irreducible error rate is even more prevalent when functional literacy of LA is 50%.
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Mary Talley Bowden MD
Mary Talley Bowden MD@MaryBowdenMD·
Organ procurement from “brain dead” patients is the most lucrative revenue source a hospital has. Perhaps this is why @TexasChildrens is in such a hurry to declare a 2 year old child with a less than 2 week old injury brain dead?
Mary Talley Bowden MD tweet media
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Andrew Caravello, DO
Andrew Caravello, DO@andrewcaravello·
@rago_carlo You nail the most important point in this article. The biology is not wrong. IL-12 is the right target. The problem is how you deliver it. That same idea is the entire thesis behind $NWBO and the #DCVax platform, and the receptor biology underneath it is why every IL-12 program keeps meeting the same wall. IL-12 is the most immunogenic cytokine a dendritic cell makes, and type-1 polarization is the decision the whole system makes about whether to mount a cytotoxic response or stand down. IL-12 drives that decision through bidirectional licensing. The dendritic cell presents antigen, the engaged T cell hands back CD40L and IFN-γ, and only then does the DC release IL-12 and polarize that T cell. The loop runs through both arms, αβ and γδ, and the same IL-12 commits CD8, CD4, NK, and γδ T cells to one type-1 program. That is why the textbook calls IL-12 the memory-programming cytokine, because it is Signal 3, but durable CD8 memory is one output of a much larger job. Signal 3 only writes that memory when one cell hands the T cell Signal 1 (antigen) and Signal 2 (costimulation) at the same synapse, in the same contact, and the cell built to run the whole loop is the cDC1. Format matters this much because of the receptor. γδ T cells cannot downregulate IL-12Rβ2, and NK cells are constitutively IL-12-responsive, so both read whatever IL-12 reaches them at full gain and cannot turn it down. Push IL-12 systemically and all of them fire at once, which is the IFN-γ storm that killed patients in the 1990s and stopped systemic IL-12 cold. Deliver it locally from a plasmid in the urothelium and you get real responses, then the durability you flagged fades, because nothing is running the reciprocal licensing loop. No type-1 polarized cell is there to couple antigen to synapse-level IL-12, so the response never consolidates into durable memory. One molecule, one root cause, two failure modes. Toxicity at one end, durability decay at the other. That is exactly why the surfactant cohort you point to is the right experiment. $ENGN Polidocanol is a serious attempt to fix delivery, and building urine IL-12 in as a PD readout is the smart way to watch whether it is working. enGene is asking the correct question. The other answer to that same question is to deliver IL-12 through the cell that evolution already uses for it. That is why NWBO and Linda Powers secured Pawel Kalinski's alpha type-1 polarized dendritic cell platform out of the University of Pittsburgh and Roswell Park. US 7,972,847, mature type-1 polarized DCs with enhanced IL-12 production. The αDC1 is not a way to get IL-12 to a tumor. It is a physiologically compartmentalized IL-12 delivery system. It presents the patient's own antigen, costimulates, and secretes high IL-12p70 in one cell, at the synapse, at the dose a single cell makes rather than the dose a syringe drives through the blood. That is how you run the licensing loop and commit the whole system to type-1 immunity instead of a transient flare, and it is why the same cytokine that killed patients as a systemic drug becomes durable immunity when a dendritic cell hands it over. Two delivery strategies, one principle. For IL-12, context is the whole molecule. You named it. I happened to write a book on it. The Biological Reboot is how your own body produces IL-12, why that production fails as you age, and what restores it. 📖 amazon.com/dp/B0GXPM2S97
Carlo Rago, PhD@rago_carlo

x.com/i/article/2062…

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Flopping Aces
Flopping Aces@FloppingAces·
These fucking people are losing their shit because someone finally wants to put a barcode on a ballot envelope and actually count what the mail delivers. That’s it. That’s the entire crime. Schumer calls it voter suppression. Elias is throwing his usual tantrum in court like the professional obstructionist he is. Padilla is out here claiming millions of “eligible voters” will be magically disenfranchised because the Post Office might notice if ballots disappear. These are the same people who spent years building and cheering ballot tracking systems when they controlled the rules. Now that a uniform standard might actually work against them, it’s suddenly the end of democracy. They don’t want chain of custody. They don’t want sent-versus-returned reconciliation. They don’t want records that last five years and can be subpoenaed. They want the current sloppy, unaccountable mess exactly the way it is ... dirty rolls, ballots mailed to ghosts and double registrants, and no reliable way to prove how many actually came back. That’s the quiet part they’re screaming about. They built a system where fraud is difficult to catch on purpose, and now they’re panicking that someone might install the most basic fucking receipt the mail has ever used for anything else. The fact that they’re this hysterical over barcodes on envelopes tells you everything about how comfortable they got with the blind spots. These people don’t fear losing elections. They fear finally having to run them without the safety net of plausible deniability. And the louder they howl, the more obvious it becomes that the old way was working exactly how they wanted it to. (article below)
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Farm Girl Carrie 👩‍🌾
Farm Girl Carrie 👩‍🌾@FarmGirlCarrie·
The fraud in this country is out of control! Dr. Oz: “We believe that 35% roughly, of the people using Obamacare exchanges may not be legit. And that actual number may translate to 5-6 million people we could be paying premiums for.”
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Eric Daugherty
Eric Daugherty@EricLDaugh·
🚨 HOLY CRAP. A bombshell report just confirmed that the groups organizing riots and agitators at Delaney Hall ICE Newark NJ have close to $1 BILLION IN ANNUAL REVENUE — Fox News NONPROFITS are involved, who get tax benefit status KNEW IT!! There's a network of well-organized and funded groups — as many as 100 — including INDIVISBLE, funded by Chinese-linked billionaire Neville Singham, plus the ACLU and more The entire operation includes public social media coordination on top of private Signal groups, run by Marxists and pro-Palestine radicals SHUT IT ALL DOWN!
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Gunther Eagleman™
Gunther Eagleman™@GuntherEagleman·
Incredible that she’s on the ballot. She failed L.A.
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Víctor Sanchez Fortun
Víctor Sanchez Fortun@Motard8559·
Más de 1.200 alemanas 🇩🇪 blancas de Colonia, fueron Violadas ò Agredidas Sexualmente en 2015 por Musulmanes de África. Solo fueron Detenidos 2 y fueron presentadas 1.215 Denuncias. Merkel y Ursula merecen Cárcel por lo que han hecho con Europa.🤨🇪🇸
Víctor Sanchez Fortun tweet media
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Sarah For Trump🇺🇸🇮🇱
A brave woman says 🏴󠁧󠁢󠁥󠁮󠁧󠁿England is a Christian nation and she doesn’t wanna hear anything about the Quran. Guess what? The cops hauled her off like a fucking terrorist. How the hell can Great Britain be saved from this nightmare?
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James Woods
James Woods@RealJamesWoods·
Keep working two jobs, suckers, while you vote for this commie piece of shit.
James Woods tweet media
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