MeadowR

Female. Mid-40s. Petite. Physically fit but carrying an extra 8 pounds and tummy fat that won’t budge unless I’m consistently keeping cals to 1200 a day MAX—aka constantly hungry So I started low dosing retatrutide, first and only peptide so far Logging my experience here.

@peptidepirate I am incredibly thirsty all the time on Reta Electrolytes are non-negotiable for me.

The Reta series pt.5🏆🏴‍☠️🏆🏴‍☠️🏆🏴‍☠️🏆🏴‍☠️ ——————————————————— Dehydration🌵🏜️ My labs showed mild dehydration at my 6 week draw on Reta which lined up exactly with how I had been feeling but did not realize🏴‍☠️ Here is why this happens🏴‍☠️ GLPs reduce thirst signaling through central nervous system effects on the hypothalamus which means you do not feel thirsty at the levels you should🏴‍☠️ Reduced food intake also means less water absorbed from food which is normally 20 to 30 percent of your daily water intake🏴‍☠️ The sodium dump and increased urinary excretion of electrolytes pulls water out of your system faster than baseline🏴‍☠️ Slowed gastric emptying changes how quickly water gets absorbed into circulation🏴‍☠️ Four pathways stacking against your hydration status at the same time🏴‍☠️ The symptoms hit quietly🏴‍☠️ Fatigue that does not match your sleep quality🏴‍☠️ Headaches especially in the afternoon🏴‍☠️ Dry mouth and skin you did not have before🏴‍☠️ Concentrated dark yellow urine🏴‍☠️ Muscle cramps and slow recovery from workouts🏴‍☠️ HRV dropping on your wearable even when nothing else seems wrong🏴‍☠️ Constipation that fiber alone is not fixing🏴‍☠️ These are not Reta side effects🏴‍☠️ These are hydration side effects from running Reta without adjusting how you drink🏴‍☠️ The bloodwork markers that catch dehydration🏴‍☠️ BUN to creatinine ratio elevated above 20 to 1 suggests dehydration🏴‍☠️ Albumin can rise🏴‍☠️ eGFR drops🏴‍☠️ Hematocrit and hemoglobin both trending up without other explanation🏴‍☠️ Sodium climbing toward the upper end of the reference range🏴‍☠️ Specific gravity on urinalysis above 1.020🏴‍☠️ Most users never see this on a CBC and BMP unless they actually look for the pattern🏴‍☠️ The fix🏴‍☠️🩹 3 to 4 liters of water daily not 2 because GLPs increase your baseline requirements🏴‍☠️ Electrolytes with every liter sodium potassium and magnesium not the sugar packed sports drinks🏴‍☠️ Drink on a schedule not just when thirsty because your thirst signaling is compromised🏴‍☠️ Front load hydration before noon since most users fall behind in the afternoon🏴‍☠️ Track your urine color first morning pull should be light straw not dark yellow🏴‍☠️ Add a pinch of sea salt to your morning water especially if you are training🏴‍☠️ Do not let mild dehydration be the reason your bloodwork your energy and your recovery all degrade quietly🏴‍☠️ 🧬🔬

Titrated up from half a mg of retatrutide to 1 mg after 4 weeks. Appetite suppression is real now Sleep is fine as long as caffeine kept to 100 mg or less Energy is crazy. Walking lots to keep up. Anxiety slightly up

My RHR hasn’t gone up on Reta But my walking HR has. Interesting.

@_9th_Life_ I’m actually thirsty all the time. 5 weeks on Reta so far.

If you're on Reta/Tirz right now, remember to drink water. I keep hearing this from guys I'm close with on their GLP-1 journey. ALL the attention is on how reta kills "food noise," but I kept seeing reports that it cuts the dehydration noise too. I never see anyone talk about it publicly, but after it was mentioned to me, I've been noticing it myself. I'm way less thirsty than I used to be. So did a search and turns out it's not just anecdotal. GLP-1s hit the same spot in the brain that controls hunger and thirst, so they suppress your water intake on their own, totally separate from the appetite effect. There's a 2011 study that showed exactly this. They even named it the "hypodipsic effect." So if you've felt like you just don't get thirsty anymore, you're not crazy. But something to be aware of. Anyone else experience this?

Part of losing weight is accepting that some meals are just… functional. Everything tasting good is what got you fat to begin with.

Here is your Wednesday morning checklist... 1️⃣ Water before coffee. 16oz minimum. 2️⃣ Outside for 10 minutes of natural light before anything else. 3️⃣ Protein at breakfast. At least 30 grams. 4️⃣ No phone for the first 30 minutes. 5️⃣ One thing written down that you will do for your health today. Anyone can show up Monday. Show up today.

Retatrutide just posted Phase 3 numbers that are hard to ignore. ~30% average body weight loss. ~70 pounds lost. Even the lowest dose outperformed what used to be considered best-in-class. But the most interesting part of the story isn't the weight loss. It's the thousands of people already using grey-market Retatrutide before there's an approved pharmacy version available. What did the trials actually do? What dose produced the best balance of results and tolerability? And why might the biggest risk have nothing to do with the drug itself?

@be_like_ice 😂😭

If you survived the emotionally unstable mother & emotionally absent father duo, how's your hyper independence, burnout and anxiety going?

@WallStreetApes Crumbl cookies are so gross too 😭

This is literally insane Crumble Cookie just launched a drink that has 186 grams of sugar - That's almost half a pound of sugar - Equivalent to 5 cans of Coke - That’s roughly 19 Krispy Kreme donuts IN ONE DRINK This should be illegal. This is more than 5x the American Heart Association’s daily recommended max for added sugar We need to Make America Healthy Again I looked into this and if you drink this regularly you can cause extreme harm to yourself - Rapid weight gain - Fatty liver disease - Huge Increased diabetes risk - Tooth decay and gum disease - Mood swings This has to stop

Lilly is currently arguing in federal court that retatrutide should qualify as a biologic, a move that could reshape exclusivity timelines for future GLP-1 and peptide-based obesity medications. Access is changing, and education matters more than ever. Know the compounds. Know the legal landscape. Know what could affect availability over time. Stay informed.

@peptidepirate This is fascinating. The first week I was on reta, my feet were cramping and they never cramp. I bought electrolytes loaded with potassium because of it.

The Reta series pt.4 🏆🏴‍☠️🏆🏴‍☠️🏆🏴‍☠️🏆🏴‍☠️ ——————————————————— The potassium problem🏴‍☠️ GLPs increase urinary potassium excretion through the same renal mechanism that drives the sodium dump I spoke about🏴‍☠️ For me this started showing up around week 6 to 8 as muscle cramps at night🏴‍☠️ Add reduced food intake and most users are pulling in less potassium from food at the exact moment their kidneys are excreting more of it🏴‍☠️ The average person needs 3500 to 4700mg of potassium daily and most are barely hitting half of that even before starting a GLP🏴‍☠️ The symptoms hit quietly🏴‍☠️ Muscle cramps especially at night🏴‍☠️ Heart palpitations or a fluttery feeling randomly during the day🏴‍☠️ Weakness or fatigue that does not match your workout output🏴‍☠️ Constipation that magnesium alone is not fixing🏴‍☠️ Brain fog and irritability you cannot pin down🏴‍☠️ These are not Reta side effects🏴‍☠️ These are potassium side effects from running Reta without supporting your electrolytes properly🏴‍☠️ The fix🩹 Track potassium on your BMP every bloodwork pull🏴‍☠️ Aim for 3500 to 4700mg daily from food first🏴‍☠️ Real food sources avocado spinach sweet potato banana white potato salmon and beans🏴‍☠️ Electrolyte supplements that include 400 to 600mg potassium not just sodium🏴‍☠️ Coconut water 1 to 2 cups daily is an easy add🏴‍☠️ (Vietnamese harvested are my favorite taste wise) Do not let a 12 dollar electrolyte upgrade be the reason your heart and muscles are misfiring🏴‍☠️ 🧬🔬

@HoosierKid31 Agree

I’m calling complete BULLSHIT on the 1g of protein/ lb of body weight. I did that for years and couldn’t get many carbs in due to the calories from protein and fats. There was a phase there for a while where high fats were the best for energy. That’s BULLSHIT! .6-.75g/lb

@_9th_Life_ I think you’re right

I predict a massive boost in popularity for GLP-1s and peptides after July 4th weekend. Here’s my rationale: Large groups across all demographics will be gathering together. Young, old, middle-aged friends, and families. Once the shirts come off at the pools and on the boats, the people who’ve dropped 30-50 pounds over the last few months are going to stick out like sore thumbs. And the ones who’ve been running MT2 will be tan as hell on top of it. Everyone’s going to be asking, “Yo, what did you do? What are you on?” And honestly, I don’t think there’ll be much gatekeeping, considering how close families and friends are. It’s not like someone asking you at work… Around family, especially with alcohol involved, you’re going to to spill the beans. I’m damn near certain we’ll see more and more “GLP-1 Summer” related news, articles, and attention brought to the peptide space. Bookmark this tweet and refer back to it after my hypothesis is confirmed.

Weight loss hack: - Skip breakfast - Double your daily step count That’s it. Try this for a few weeks, and thank me later.

@rorynotsorry Maybe I’m just more sensitive. First time on one of these. Just bumped up to 1 mg after 3 weeks at .5, and while I still get hungry, I can’t eat large portions.

I’m convinced you microdosers are making stuff up. I cut down my dose to 2mg a week ago and I’m 5-tacos and three plates of nachos deep at this Graduation party.

@DrCamRx My sleep has been fine on low doses of Reta. My energy though feels like I’m caffeinated daily—so now I don’t need to take in caffeine.

People fail to understand that: 1) Retatrutide is only stronger than Tirz at higher dosages 2) it’s bc Reta’s glucagon agonism is like caffeine, it’s a cardiac stimulant: Heart rate increases, HRV decreases. You may sleep less or poorer. Tirz is better for most people.

@peptidepirate Crazy. I’m on week 4 and had my first run in with this issue. Course correcting now.

The dark side of Reta 🏆💩🏆💩🏆💩🏆💩 ——————————————————— The constipation💩🏆💩🏆💩🏆💩🏆💩 For me it started around week 4 and peaked between week 8 and 10🏴‍☠️ This is not uncommon for GLP use the drug literally slows the gut down🏴‍☠️ Here is why it actually happens🏴‍☠️ GLPs slow gastric emptying by 40 to 50 percent which means food moves through your entire digestive tract slower🏴‍☠️ Reduced food volume means less bulk to trigger normal bowel movements🏴‍☠️ Less water intake on a GLP because thirst signaling shifts too🏴‍☠️ Reduced fiber intake when overall food volume drops🏴‍☠️ Slower transit time also means your body reabsorbs more water from the stool making it harder to pass(this is a massive reason it occurs)🏴‍☠️ Four pathways stacking against your gut at the same time🏴‍☠️ And it is not just uncomfortable it cascades and can compound🏴‍☠️ When food sits too long your body reabsorbs toxins your liver was trying to clear🏴‍☠️ Gut bacteria shift toward less helpful strains🏴‍☠️ Bile acid recycling gets disrupted which messes with cholesterol and hormone clearance🏴‍☠️ Inflammation in the gut wall climbs quietly🏴‍☠️ The symptoms hit quietly🏴‍☠️ Bloating that does not go away🏴‍☠️ Bowel movements every other day instead of daily🏴‍☠️ Skin breaking out for no obvious reason🏴‍☠️ Mood drops you cannot explain🏴‍☠️ Midnight stomach cramps 🏴‍☠️ These are not Reta side effects🏴‍☠️ These are gut side effects from running Reta without supporting your motility🏴‍☠️ The fix🩹🏴‍☠️🩹🏴‍☠️🩹🏴‍☠️🩹🏴‍☠️🩹🏴‍☠️🩹🏴‍☠️🩹 ——————————————————— 2 to 3 liters of water daily🏴‍☠️ TUDCA for bile flow support🏴‍☠️ 20-25 grams of fiber from real food psyllium husk or ground flax🏴‍☠️ If taking fiber sups spread throughout the day🏴‍☠️ Magnesium citrate 200 to 400mg at night🏴‍☠️ Walk 20 to 30 minutes after meals to activate peristalsis🏴‍☠️ Probiotics if you have been backed up for weeks🏴‍☠️ Do not let a constipation cascade be the reason your bloodwork bile acids and overall Reta experience suffers 🏴‍☠️ 🧬🔬

@AlpacaAurelius Every time

me indoors: "life is shit" me in the sun for 5 minutes: "everything is a blessing, true love exists, God is real"

Nobody told me a $1.50 can of tuna could hit harder than a $15 grilled salmon fillet. Mix it with Greek yogurt, Dijon mustard, diced red onion, and black pepper… no mayo, no excuses. Stuff it into a whole wheat wrap with spinach and cucumber and you've got 30g of protein for under $2.50 a meal. I've made this for lunch three days straight and I’m going to do it again tomorrow. Stop convincing yourself eating well is expensive when you haven't even tried.

What if everything you thought you knew about cholesterol was wrong? Not all LDL is dangerous. Not all saturated fat is bad. The real driver of heart disease is inflammation. And the number one cause of inflammation is the ultra-processed food we've been told is heart-healthy for 50 years.