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Today I made this "Hierarchy of Immunotherapy" to organize my notes/thoughts.
Any feedback? Corrections/improvements?
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Nick Yoder
1.7K posts
Nick Yoder
@NickYoder86
Recovering Mathematician ~ Pilot, Sailor, Motorcyclist, Ex-Firefighter ~ Greatest desire: Advance cancer biology via Math + Systems Engineering
New York, NY Beigetreten Temmuz 2011
809 Folgt1.5K Follower
I grew up on Walker Texas Ranger.
I hope death is ready to get roundhouse kicked in the face.
My favorite Chuck Norris facts:
1. When Chuck Norris doesn’t do push ups, he pushes the Earth down
2. The Boogeyman checks his closest for Chuck Norris.
3. If you can see Chuck Norris, he can see you. If you can’t see Chuck Norris, you may be seconds away from death.
4. Chuck Norris doesn’t wear a watch, he decides what time it is.
5. A cobra once bit Chuck Norris. After 5 days of agony, the Cobra finally died.
6. Jack was nimble. Jack was quick. But Jack couldn’t dodge Chuck’s roundhouse kick.
7. Chuck Norris’ diary is called ‘Guinness Book of World Records’
8. When Chuck Norris stared into the abyss, the abyss looked away.
9. Chuck Norris doesn’t sleep. He waits.
10. Voldemort refers to Chuck Norris as “You know who”.
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Nick Yoder retweetet
Every book I read gets a 1-10 rating.
Here are the 22 books (so far) to earn a 10/10 rating.
📚🧵
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Nick Yoder retweetet
Nick Yoder retweetet
An Abu Dhabi royal backed a secret $500 million investment in Trump’s crypto company. Months later, U.A.E. won access to tightly guarded American AI chips. on.wsj.com/4qgD3b5
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Nick Yoder retweetet
DOJ has since killed this link. This is what was there:
Jake Tapper 🦅@jaketapper
New Epstein docs justice.gov/epstein/files/…
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Nick Yoder retweetet
Thomas Massie is going NUCLEAR on Trump’s regime change war in Venezuela.
“How did it work out in Cuba, Libya, Iraq, or Syria?”
“Do we want another Afghanistan in the Western Hemisphere?”
“This is about oil and regime change.”
“Previous presidents told us to go to war over WMDs, weapons of mass destruction, that did not exist.”
“Now it’s the same playbook, except we’re told that drugs are the WMDs.”
“James Madison warned us that in no part of the Constitution is more wisdom to be found than in the clause which confides the question of war and peace to the legislature—not the executive.”
“The framers understood a simple truth: to the extent that war-making power devolves to one person, liberty dissolves.”
“By escalating toward war, we would predictably create countless refugees.”
“Are we prepared to receive swarms of the 25 million Venezuelans who will likely become refugees?”
@RepThomasMassie @MassieforKY
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I saw this earlier today and didn’t think it was real.
@WSJ just confirmed it’s authenticity.
OSINTdefender@sentdefender
In a letter attributed to Jeffrey Epstein, written from prison the day before his mysterious death and addressed to fellow sexual predator Larry Nassar, Epstein stated, “Our president also shares our love of young, nubile girls. When a young beauty walked by he loved to ‘grab snatch,’ whereas we ended up snatching grub in the mess halls of the system. Life is unfair.”
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@moseskagan @paulg Well said.
I think even most of his supporters would agree with this assessment.
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@paulg Separate from his policies (some of which I agree w), he's in the bottom 5-10% of the American population in terms of basic decency
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We will be shocked later that a US president conducted himself the way he does. We're used to it now, but it truly is an aberration.
Manu Raju@mkraju
Trump’s message about Rob Reiner and his wife, who were found dead in their home
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Nick Yoder retweetet
AI-designed proteins that survive 150 °C and nanonewton forces
Proteins are usually fragile machines. Heat them, pull on them, or send them through a high-temperature sterilization step (like those used in hospitals), and most will unfold and aggregate, losing their function. Yet many natural systems—like muscle titin or spider silk—hint that if you organize β-sheet hydrogen bonds in the right way, you can get remarkable mechanical strength and thermal resilience.
Bin Zheng and coauthors take that idea and push it to the extreme. Starting from the titin I27 domain, they use an AI+MD pipeline—RFdiffusion for backbone generation, ProteinMPNN for sequence design, ESMFold/AlphaFold2 for structure prediction, and steered/annealing MD for screening—to systematically elongate the force-bearing β strands and maximize backbone hydrogen bonds in a shearing geometry.
Across multiple design rounds, they grow the network from 4 to 33 backbone H-bonds, creating a “SuperMyo” series of proteins with unfolding forces above 1,000 pN—roughly 4× stronger than I27 under the same pulling conditions. Remarkably, these proteins not only refold after force, but also retain structure and function after exposure to 150 °C and repeated high-temperature sterilization cycles, and can be used as crosslinkers to make hydrogels that survive those treatments intact.
The message is powerful: by combining generative protein design with physics-based simulations, it’s now possible to turn a simple principle—pack as many shear-mode hydrogen bonds as possible into β sheets—into synthetic proteins and materials that rival or surpass nature’s own mechanostable systems, enabling protein-based hydrogels and biomaterials that remain functional under conditions that would normally destroy conventional proteins.
Paper: nature.com/articles/s4155…
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@paulg @OfficialBBrooks With just Obama it would be a conversation.
With Trump it would be an incoherent monologue.
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@OfficialBBrooks It would be more interesting to have dinner with just Obama.
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A reminder, since we've practically forgotten, of what real confidence looks like.
Barack Obama@BarackObama
I couldn’t leave Chicago without getting a cut from my old barber, Zariff!
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One more thought and then gym time:
It took 4,900 lifespans before humans were able to circumnavigate the Earth, in a wooden ship with cloth sails.
From there it took 5 more lifespans to land on the Moon, Mars, and escape the solar system.
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This is absolutely incredible tech.
Image a blind person can now put on a pair of stylist Warby Parker glasses (cameras in frame) and be able to see perfectly.
The retinal implant is 2mm x 2mm x 0.1mm
You likely wouldn’t even know the person you are talking to was biologically blind.
youtube.com/shorts/7a2DAXi…
YouTube
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To clarify, my question is not whether people know the history/origin.
But do most people know that Left/Right fundamentally means the innate sameness or difference in humans?
For example random MS exec last night just believed “if it’s in NY schools it’s far-left”.
Likewise the vast majority of people don’t realize that Christianity (actual Christianity…Jesus, Gospels, Sermon on the Mount) is ultra-ultra-left.
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Here’s a question for the Internet, I had a conversational last night with an educated/successful guy (exec at Morgan Stanley). But was surprised that he didn’t know what politically “Left” and “Right” actually mean or how to apply the terms in real world situations.
I was surprised. But the more I think about it, maybe I’m just assuming this is more commonly known than it actually is.
Thoughts?
Backstory:
The terms “Left” and “Right” originally come from the French Revolution. After the King was deposed, the National Assembly would debate how to run France — and people naturally began sitting next to others who shared similar worldviews.
A spectrum formed.
Far Right = those who wanted to restore monarchy — a belief in structured hierarchy, inherited leadership, and that people are fundamentally different.
Far Left = those pushing toward democracy and universal suffrage — a belief that people are fundamentally the same in rights, dignity, and capability.
That axis — innate equality vs. innate difference — is where “Left vs. Right” comes from.
Further Left = stronger belief in universal sameness.
Further Right = stronger belief in natural differences.
I personally consider myself center-right.
I’m drawn to meritocratic hierarchies (not inherited titles) — like the military or well-run corporate structures. I believe capitalism aligns incentives and allocates more responsibility + resources to those with proven ability, skill, intelligence, or experience.
So when someone doesn’t understand why NYC’s specialized HS entrance exams (Stuy, Brooklyn Tech, etc) are seen as a “right-leaning” mechanism — or why California eliminating AP math to “eliminate differences in outcomes” is a left-leaning move — it tells me they don’t know this origin.
How common is it to actually know what “Left” and “Right” originally meant?
Is this one of those things that I think is common knowledge, but it turns out only 0.3% of people know?
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Quick update. Gemini 2.5 Pro is the first model to successfully answer this math problem.
(Designed specifically to leverage things humans are good at and AI is poor at)
Nick Yoder@NickYoder86
Hearing how good Grok 4 is at math. I dusted off a semi-hard riddle I used to give my interns (below). A smart human can work out the math in 5-10 min. Grok 4: Wrong Gemini: Wrong GPT (every version): Wrong Claude (Sonnet/Opus 4): Wrong DeepSeek, etc I'm sure in a few months this will be easy for an AI. But none have solve it correctly, thus far.
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Nick Yoder retweetet
Excellent post by @SparksRemarks on “To Do” lists and how to reframe into “Opportunities”.
forcingfunction.com/articles/oppor…
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Nick Yoder retweetet
How to increase agency *and* have fun:
Get a giant whiteboard in your home.
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What’s really interesting is when you think about the mathematical measures (specific to fractals) that could differentiate between efficient space-filling curves (Sierpinski, Hilbert, Peano etc) and the more chaotic biological analogs.
Mathematical/clean space-filling curves:
1. Low Mandelbrot lacunarity
2. High self-similarity
3. Low Kolmogorov complexity
Biological space-filling (brains and cabbages):
1. High Mandelbrot lacunarity
2. Low self-similarity
3. VERY HIGH Kolmogorov complexity (especially brains)
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The real answer is that it’s a space-filling curve, which is the natural consequence of any surface of dimension n growing within a topological space of higher dimension.
This, specifically, occurs because a 2-manifold (the cortex or cabbage sheaves) begins to grow within a 2-sphere (empty “ball”, either skull or outer cabbage sheaf).
The growing manifold then folds in order to efficiently fill the space.
Interestingly, if you measure the fractal dimension of a space-filling curve, the “foldiness” of the manifold approaches the dimension of the higher dimensional “ball”.
So in either the cabbage or the brain, a 2-dimensional manifold grows “into” a structure of fractal dimension that in humans both approached 3 and induced a selection pressure wrt skull size, which was itself eventually upper-bounded by female hip width hitting a functional limit.
With all this context on board, the symmetry appears perfectly natural, and one can generalize the idea to the dynamics of any organic growth within the constraints described above.
Without it, the symmetry appears supernaturally mysterious.
Many things are like this.
Nicole@elocinationn
Why does my cabbage resemble the way the human brain folds (gyrification)? Is my cabbage conscious?
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