Ryan Hobson

Had a lot of fun writing this news & views for @NatImmunol⁩ paper by @RyanMHobson⁩ and ⁦@WassimElyaman⁩ - congrats on publishing this new “blueprint” of brain border immunity! nature.com/articles/s4159…

Clonally expanded tissue-resident CD8+ T cells within the leptomeninges of individuals with neurodegenerative diseases nature.com/articles/s4159… @NatImmunol preview by @EnnerfeltHannah nature.com/articles/s4159… @WassimElyaman @Columbia @RyanMHobson

Clonal CD8+ T cells populate the leptomeninges and coordinate with immune cells in human degenerative brain diseases nature.com/articles/s4159…

Excited to share that our paper is now live in Nature Immunology. We identified highly expanded CD8+ T cell clones in the human leptomeninges and uncovered key changes in this immunological niche during neurodegeneration. I am grateful to an incredible group of coauthors and collaborators, including @WassimElyaman, for their support on this project. @ColumbiaMed nature.com/articles/s4159…

CHOIR is now online @NatureGenet! CHOIR is a new clustering method for single-cell data that evaluates whether clusters represent statistically distinct cell populations. CHOIR scales to millions of cells and works with single-/multi-omic data of any type! nature.com/articles/s4158…

@WassimElyaman @NeilShneider @bradshaw2280 @soyonhonglab @samhslevy @DallinDressman @olivia_rifai It was a great symposium. Congrats Wassim, as well as the rest of the organizing committee

Another exciting day of TCB2025 and inspiring conservations @NeilShneider @bradshaw2280 @soyonhonglab @samhslevy @DallinDressman @RyanMHobson @olivia_rifai Qizhi Tang

Doing good science is 90% finding a science buddy to constantly talk to about the project.

Out in @CellCellPress now with added data and analysis! @Huixin_BJ and colleagues report that the choroid plexus has specialized epithelial-immune synergy that modulates epithelial barrier plasticity during brain inflammation. authors.elsevier.com/sd/article/S00…

In a mouse model of #Alzheimer’s disease, amyloidosis itself triggers age-related #oligodendrocyte and #myelin damage mediated by CD8+ T cells that promote the accumulation of interferon-activated myelin-damaging #microglia nature.com/articles/s4159…

Great to see hard work being rewarded. Congratulations @ClaireFCastro @rosenzweig_a Jason Roh and all coauthors!

Looking forward to sharing what we have discovered over the course of my PhD. Thanks @WassimElyaman for your support over the years!

Excited to share our group's first manuscript describing new anatomical connections that allow the eyes to act as an "immunological window to the brain" 👁️🧠 (1/) nature.com/articles/s4158…

@FOCISimmunology Congratulations @WassimElyaman and @KhosraviLabMayo !

FCE Collaboration Travel Grants Recipient Announcement📢 This travel grant is to facilitate communication & scientific exchange among FCE centers providing financial support for collaboration and/or research-sharing opportunities. Congratulations! ow.ly/E8zZ50Qub8w

Reserve your spot for our upcoming webinar to hear how the Elyaman lab at Columbia University has delineated a first-in-human comprehensive view of the immunological landscape in the brain and its borders with the #MA900 Multi-Application Cell Sorter. ➣ ow.ly/ErX150QsgTl

@WassimElyaman @Columbia @WassimElyaman it was a great inaugural symposium. Inspiring talks from leaders in neuroimmunology and a welcoming environment to discuss science at the poster session over lunch. What more could you ask for?

Group photo at the end of a long exciting day at the T Cells in the Brain symposium ⁦⁦@Columbia⁩ #TCB2024

@smeetonlab @TroyAndFish @mulia_jo @Nature_NPJ @CSCIColumbia @ColumbiaGenDev Congratulations Troy and team!

📢Tendon/ligament/regeneration enthusiasts! I'm pleased to announce that @TroyAndFish and @mulia_jo's paper on dedifferentiation and ECM remodeling in regeneration is out today in @Nature_NPJ Regenerative Medicine. doi.org/10.1038/s41536… @CSCIColumbia @ColumbiaGenDev #zebrafish

A genome-wide in vivo #CRISPR screen identifies essential regulators of T cell migration to the CNS in a multiple sclerosis model New from @kerlab @KawakamiLab @arekken @claradelarosa96 et al. nature.com/articles/s4159…

CXCR6 orchestrates brain CD8+ T cell residency and limits mouse Alzheimer’s disease pathology @hongbo_chi @NatImmunol nature.com/articles/s4159…

Senolytic therapy in mild Alzheimer’s disease: a phase 1 feasibility trial @NatureMedicine nature.com/articles/s4159…

@ConnorMonahan8 @FGarrettiPhD @DAgalliu Congratulations @ConnorMonahan8 and team!

I'm excited to share that our paper on autoimmune mechanisms in Parkinson's disease is officially out in Neuron today! Congrats to my amazing co-author @FGarrettiPhD and a big thank you to my mentors @DAgalliu and Dave Sulzer! sciencedirect.com/science/articl…