SosaLab

New insights into the mechanochemical coupling mechanism of kinesin–microtubule complexes from their high-resolution structures doi.org/10.1042/BST202…

Congrats @arnegennerich and all, this is a huge breakthrough to have such detailed structures of KIF1A bound to microtubules! Very important work. Thank you from all our families and the whole community.

High-Resolution structures of microtubule-bound KIF1A and its pathogenic variant P305L biorxiv.org/content/10.110…

Nucleotide-free structures of Kif20A illuminate the atypical allostery in this mitotic kinesin-6 biorxiv.org/content/10.110…

Our recent work in collaboration with the Allingham's lab describing the mechanism of combined motile and depolymerization activities by a kinesin-8 just came out! nature.com/articles/s4146…

Our latest preprint on the Kinesin-8 combined motile & microtubule depolymerization mechanism dlvr.it/SKrQYT

nature.com/articles/s4146… Just out! Significant additions to the preprint biorxiv.org/cgi/content/sh… are the separation of coexisting motor-head conformations and improved resolution (2.7-3.9 Å now). @matthieuBenoit1 @HernandoSosa4 @SEMC_NYSBC @cryoEM_Papers #microtubule #kinesin

Glad to see our paper finally coming out with 18 cryo-EM snapshosts of the molecular motor KIF14. biorxiv.org/content/10.110…

18 new #cryoEM structures of the kinesin molecular motor KIF14 reveal its translocation mechanism @SosaLab4 biorxiv.org/cgi/content/sh… Collaboration with Kwok lab. Data collected at @SEMC_NYSBC #EinsteinMed #MTmotors #kinesins #microtubules #biophysics @cryoEM_Papers #cellbiology

Sosa lab @EinsteinMed provides structural insights into kinesin-13 mediated microtubule depolymerisation. go.nature.com/2HQuXoi