Yale Pathology

The Politi Lab @YaleMed seeks answers on #LungCancer - How Tumors Develop, Resist Treatment and What Comes Next. Dr. Politi and her Lab Members discuss their work here: bit.ly/47R0kKl

Today at 12:15pm PST, Dr. Katerina Politi @yalepathology presents during the @AACR Annual Meeting 2026 Highlights Plenary Session on "Basic cancer science and translational research." abstractsonline.com/pp8/#!/21436/s… @SmilowCancer

Research presented by Mariana Do Carmo @yalepathology shows tumor suppressor gene loss plays a major role in how EGFR-mutant #lungcancer grows and responds to therapy. Certain gene losses can accelerate tumor growth or drive resistance to EGFR inhibitors. #AACR26 @AACR @SmilowCancer @OncoAlert @StockhammerPaul

.@Hui2Pei & @NataliaBuzaMD of @YaleMed are presenting at the 31st Congress of the Chinese Society of Pathology/15thAnnual Meeting of Chinese Pathologists, April 23-26, in Xi’an, China. The meeting’s theme is, “Frontiers in Pathology: Integrating Precise Diagnosis into Practice.”

Our National Medical Laboratory Professionals Week celebrations are in full-swing! Today, it was a cultural potluck lunch, along with Silly Hat Day (is that @Angelique_Levi_?). The fun (and, of course, the work) continues all week here @YaleMed. #LabWeek

.@RongFan8 opens #AACR26 symposium on “Cutting-Edge Advances in Hematology,” with key advances shaping #hematology: - Spatial omics - Functional genomics - Immunotherapy as a cornerstone therapy for hematological malignancies, including CAR-T - Emerging AI-driven approaches to research & clinical practice @yalepathology @AACR @OncoAlert @YaleHematology

New research presented by Daulet Aiyymnayev @yalepathology @YaleOVS at #AACR26 shows that loss of BAP1 in uveal #melanoma reshapes gene regulation and cell identity. It switches tumor cells away from a normal state toward a more invasive state. @MathieuBakhoum @AACR @OncoAlert @SmilowCancer

New research from @yalepathology at #AACR26 shows that where immune cells sit in #NSCLC tumors matters. Clustering of CD8+ and CD20+ T cells inside tumors is linked to better survival, while patterns in surrounding tissue may signal worse outcomes. @AACR @SmilowCancer @OncoAlert

Yang Liu @yalepathology used spatial epigenomic profiling to map the evolution of pancreatic NETs. Two distinct tumor states emerge: one focused on rapid growth signals, and another driven by KRAS and EMT-linked invasive behavior. #AACR26 @JingDuMD @AACR @OncoAlert @SmilowCancer

Inspired by visiting Cornell to give grand rounds today and brainstorming with the brilliant @SanjayPatelMD—thank you for inviting me particularly given your brand new addition/chaos agent, baby Ravi! Bonus: reunion w/my 1st surgpath attending at Yale, Lihui Qin. @yalepathology

In today's afternoon #AACR26 poster session at 2pm PST, we have research being shared by Dr. Han Xu @NeurologyYale; @aitymbayev; Dr. Yang Liu; Abigail Koomson; Miguel Lopez de Rodas Gregorio @yalepathology; and Dr. Xiaoling Li @Yale_Urology. @SmilowCancer @AACR

This afternoon at 2:30pm PST #AACR26, @RongFan8 will be co-chairing a Mini-Symposium: Cutting-Edge Advances in Hematology. abstractsonline.com/pp8/#!/21436/s… @SmilowCancer @AACR @yalepathology

We’ll be celebrating National Medical Laboratory Professionals Week (April 19-25) with different events each day. #LabWeek is an annual celebration of medical laboratory professionals & pathologists who play a vital role in health care & patient advocacy.

.@jsnibbor shares how the use of spatial transcriptomics reveals response vs resistance to T-DXd in metastatic #breastcancer #MBC. Responders show stronger hormone & cell-adhesion signals, while resistance is linked to protein breakdown & more suppressive tumor features. #AACR26 @yalepathology @AACR @SmilowCancer @OncoAlert @YaleBreast

At #AACR26, Mengni He @yalepathology shares how spatial transcriptomics explains response vs resistance to sacituzumab govitecan for metastatic #breastcancer #MBC. @YaleBreast @AACR @OncoAlert @SmilowCancer

Join us for #Pathology Grand Rounds on Thursday, April 23 at 12:30 PM ET as our former colleague @mreyesm of @umiamimedicine returns to @YaleMed to discuss, “How Pediatric Pathology Reveals Cancer Predisposition Syndromes.” @YaleCancer tinyurl.com/3s2rd8p9

.@yalepathology presents an AI-driven analysis of TILs in #NSCLC, which shows promise as a biomarker for immunotherapy response. Quantitative TIL scoring was linked to improved survival, highlighting the potential of quantitative clinical readings in #pathology. #AACR26 @AACR @SmilowCancer @OncoAlert

At @AACR’s James S. Ewing–Thelma B. Dunn Lecture in Pathology #AACR26, Dr. David Rimm @yalepathology highlighted a shift in #pathology—from subjective “reading” to precise measurement. He called for moving beyond IHC scoring to quantitative, fluorescence-based methods, integrating spatial + molecular data, and using “selective biomarkers” to better match patients to therapies. @SmilowCancer @OncoAlert

Demetrios Braddock, MD, PhD, Professor of #Pathology @YaleMed, was recently honored by the patient community for his leadership in developing a promising therapy for rare genetic neonatal calcification disorders. tinyurl.com/mrjbtdz9

How do you cut calories to slow #aging without compromising health? @VishwaDeepDixi1 of @YalePathology & @YaleMed explores that question in his latest study & may have found a potential answer in an immune-related protein. tinyurl.com/347ts96d

Join us in congratulating and welcoming our Chief Pathology Residents for the 2026-2027 academic year @YaleMed: Claire Krasinski, DO, MS; Razie Amraei, MD, PhD; Carlos Mauricio Mejia Arbelaez, MD, MPH; and Taylor Takasugi, MD, PhD @YalePathRes