Jack Robbins

.@jsnibbor shares how the use of spatial transcriptomics reveals response vs resistance to T-DXd in metastatic #breastcancer #MBC. Responders show stronger hormone & cell-adhesion signals, while resistance is linked to protein breakdown & more suppressive tumor features. #AACR26 @yalepathology @AACR @SmilowCancer @OncoAlert @YaleBreast

Jack Robbins @jsnibbor shares new data from @yalepathology showing that HER2 measured by Troplex™ is linked to longer benefit from T-DXd, while higher TROP2 surprisingly predicts shorter response #SABCS25. A key question ahead: can HER2 and TROP2 (amol/mm²) help guide treatment choice between T-DXd and SG? @SmilowCancer @SABCSSanAntonio @OncoAlert

Jack Robbins presents a quantitative assay for TROP2 and HER2 expression in #breastcancer developed by @RimmPathology to help with treatment decision making @SABCSSanAntonio. #bcsm #SABCS23 @yalepathology @SmilowCancer @YaleMed @YNHH

@elonmusk What's the deal with excluding chemical energy sources to store solar energy, like hydrolysis->Hydrogen? If you can't make batteries that store the energy, make hydrogen and pipeline it to syngas plants.

One square mile on the surface receives ~2.5 Gigawatts of solar energy. That’s Gigawatts with a “G”. It’s ~30% higher in space. The Starlink global satellite network is entirely solar/battery powered. Factoring in solar panel efficiency (25%), packing density (80%) and usable daylight hours (~6), a reasonable rule of thumb is 3GWh of energy per square mile per day. Easy math, but almost no one does these basic calculations.

Once you understand Kardashev Scale, it becomes utterly obvious that essentially all energy generation will be solar. Also, just do the math on solar on Earth and you soon figure out that a relatively small corner of Texas or New Mexico can easily serve all US electricity.

@breeadail @realDonaldTrump Damn

What do you think about this new ad from @realDonaldTrump?

Purple Llama.

@Dovid_Kotkes @JessLeBerichel @SinaiImmunol @MiriamMerad @IcahnMountSinai Hope they find someone for the job. I have enough work to do for my PhD, haha.

@JessLeBerichel @SinaiImmunol @MiriamMerad @IcahnMountSinai Cc @crobbins327

WE ARE HIRING! We are looking for a computational scientist to join our sequencing and imaging analysis team @MiriamMerad lab. Come join our dynamic team @IcahnMountSinai

@slava__bobrov @Dovid_Kotkes

One of the most detailed models of a human cell obtained using X-ray, NMR, and cryoelectron microscopy: #biology

Microetchings are handmade lithographs that manipulate light on a microscopic scale to control the reflectivity of metallic surfaces. The technique was invented by Greg Dunn & Brian Edwards to change the way in which the viewer experiences a painting buff.ly/2jofQVe

What can your saliva, smartphone, #CRISPR and 15 minutes get you? A quantitative #COVID19 test result w/ viral load advances.sciencemag.org/content/early/… @ScienceAdvances by @Tony_Y_Hu @Tulane and collaborators

FDA places clinical hold on trial of CAR-T for metastatic pancreatic, prostate cancer bit.ly/2IH5tfG

Here is an animation showing a normal pancreatic tissue obtained using CODA, a method to produce 3D maps of large volumes of tissues and tumors. From serially cut H&E sections to digital volumes, spanning cm to micron length scales. More details here: biorxiv.org/content/10.110…

We present a method to produce 3D maps of large volumes (multi cm^3) of human tissues and tumors at single-cell resolution. See more details here: biorxiv.org/content/10.110…

Neutrophils on patrol.....

🔬 Research from Drs. @MoEbrahimkhani, @samira_kiani1 and @PLRC_PittLiver scientists: Genetic engineering transformed stem cells into working #MiniLivers that extended the life of mice with liver disease. #organoids 🔓 Full article bit.ly/2VOYHXZ

How do you detect #SARSCoV2 rapidly on your smartphone with #CRISPR genome editing and no amplification? Like this: cell.com/cell/fulltext/… @CellCellPress today, by @TheOttLab @itsparinaz @FletcherLab_UCB @czbiohub @doudna_lab @GladstoneInst @UCSFMedicine

A recent editorial by Pedersen et al. 'Putting Warburg to work: How imaging of tumour acidosis could help predict metastatic potential in #BreastCancer ' has just been published in the #Metastasis special issue. go.nature.com/3oi52rn

The Metabolic Underpinnings of Ferroptosis dlvr.it/Rmwcc2

Thrilled to share new work from my lab @Stanford in @NatureBiotech today on generating functional cortico-striatal #assembloids, striatal #organoids & using them to model disease. Work led by the amazing @myym_yuki with help from @Minyin_Li @fikribirey @omerevah @TheteMayuri.