CrowDsourcing COndensate Database & Encyclopedia

We're really excited that CD-CODE is now cross-referenced by @uniprot and has already been included in the latest release: uniprot.org/release-note... Spreading knowledge about #biomolecular #condensates 🥳 🦋more news from us: bsky.app/profile/cdcode…

The latest release was supported by the #condesathon joined by MPI-CBG condensate community🤩 Big #thankyou to all the participants for your support and enthusiasm!💜 more news from us: bsky.app/profile/cdcode…

☀️summer is here - and so is CD-CODE v1.10 release! 💡CD-CODE has now 719 manually curated #condensates 💡Check out new #condensates and updated #protein - condensate connections at cd-code.org #Bioinformatics #DatabaseUpdate #cdcode bsky.app/profile/cdcode…

The latest April release of @uniprot cross-links biomolecular condensate entries to CD-CODE. uniprot.org/release-notes/… For example, one can see that Protein Q9VD51 is a member of the Nucleolus uniprot.org/uniprotkb/Q9VD… @cdcode_org @agnestothp

🍃CD-CODE update v1.09 is here!🍃 👀Check out the new #biomolecular #condensates at cd-code.org 👀We're continuing to update #Protein - #condensate connections and resolve issues! Join us on🦋 to follow more regular updates: cdcode.bsky.social

Our PICNIC tool predicts condensate-proteins regardless of their structural disorder across organisms @NatureComms. Congratulations to @AHadarovich for developing the algorithm and to Hari @HymanLab for the experiments! @mpicbg @csbdresden @PoLDresden nature.com/articles/s4146…

✨Winter CD-CODE update to v1.08!✨ ❄️ New #biomolecular #condensates added (total ⚪: 680) ❄️ #Protein - #condensate connections updated ❄️ Species attributes fixed 🤩 👀Check the current version here: cd-code.org Join us as a contributor: cd-code.org/signup

🔊Calling the hive mind of the #Condensate Community: Join us in curating the CD-CODE! Do you have a favorite condensate or have discovered one that’s not yet in CD-CODE? We want your input and expertise!🧠 🔗Easy sign-up here: cd-code.org/signup Add a new condensate ⤵️

☝️SG is one of the most populous condensate in CD-CODE, with human (cd-code.org/condensate/DEE…) and yeast (cd-code.org/condensate/E03…) proteomes being the most characterized up to date! Are you a stress granule expert or enthusiast? 🦉Join us as a curator: cd-code.org/signup

Various species have different Stress Granule proteomes: 🔵Translationally stalled mRNAs, 🔵translation initiation factors, 🔵RNA-binding proteins, and 🔵non-RNA-binding proteins are among the main constituents of SGs.

🚨October Condensate of the Month is Stress Granule! #StressGranules (#SGs) are dynamically forming cytoplasmic condensates that form in response to various cellular stresses. 🤩In CD-CODE there are more than 10 species and more than 1300 #protein associations described for SGs.

📚Read more about +TIP body and its proteins: doi.org/10.1371/journa… nature.com/articles/s4155… nature.com/articles/s4155…

These condensates concentrate proteins needed for growing tip of the #microtubule. +TIP bodies have been described in... ...🐁mammalian cells (Wu et al., 2021), ...🧪S. pombe (Maan, Reese &Volkov et al., 2023), ...🧪S. cerevisiae (Meier, Farcas &Kumar et al., 2023 @LabBarral

💫September Condensate of the Month is +TIP body!💫 These #condensates form at the growing plus end of #microtubules, crucial for cell division and transport.🦠🧫 : cd-code.org/condensate/909… Check out the protein composition of +TIPs in different organisms ⤵️

New Season 🍂🌿 - new #CDCODE release! 🥳Version 1.07 is here: cd-code.org 🌟We focused on improving #species attributions and updating missing #condensate features. Help us with your condensate expertise!🧠 Join us to become a contributor: cd-code.org/signup

📚Read more about MARDO and its proteins: doi.org/10.1093/nar/gk… doi.org/10.1007/s00018… science.org/doi/10.1126/sc… 3/3

🔵MARDO is a #membraneless compartment that stores maternal mRNAs, important for early embryonic development. ZAR1, an RNA-binding protein with an intrinsically disordered region (#IDR), plays a major role in MARDO assembly and facilitates clustering with #mitochondria. 2/3

🌟Excited to introduce #MARDO as CD-CODE August "Condensate of the Month"!🌟 MARDO stands for Mitochondria-Associated RNA DOmain: cd-code.org/condensate/089… 💡It was first discovered and described by Cheng et al. @SchuhLab in #mammalian (mouse, bovine and human) #oocyte. 1/3🧵⤵️

📢We've just updated CD-CODE to v1.06!🎉 ✨11 new #condensates integrated (total: 670) ✨ 21 new #proteins associated (total: 9672) ✨ 24 condensate-protein attributes updated 👀Check the current version here: cd-code.org #DatabaseUpdate #NewRelease #Bioinformatics

CD-Code has been updated to v1.05: ✨ 14 new condensates integrated, making a total of 659 condensates ✨ 14 new proteins associated, make a total of 9651 proteins ✨ 34 condensate/protein attributes updated Visit our website here: cd-code.org