Sam Lambert

@gamzeandgursoy @Cambridge_Uni Welcome to Cambridge 👋

Dear friends, after many wonderful years in the U.S., it’s time for a new adventure. My lab and I are moving to the Department of Applied Mathematics and Theoretical Physics at the @Cambridge_Uni starting April 2026. If you’re in the UK, come say hi. If you’re not, come visit 🙂

🚨 Funded PhD Opportunity (Oct 2026 start) 10 funded 4-year PhD studentships are available through @TheBHF doctoral training programme focused on preventing cardiovascular disease through innovative, data-driven approaches For more info & how to apply: tinyurl.com/yc7j5s67

It's very hard to prevent vasovagal reactions, such as fainting, as evidenced from this study of nearly 1.4 million blood donors thelancet.com/journals/lanha…

We hope it's easy to use with tutorials for UKB (pgsc-calc.readthedocs.io/en/v3-alpha.1/…) & All of Us (pgsc-calc.readthedocs.io/en/v3-alpha.1/… )! But feel free to contact us on Github: github.com/PGScatalog/pgs…! With that, happy holidays from the PGS Catalog team! 🎁 🎄

The new alpha only implements PGS scoring at the moment, but the roadmap will reimplement our existing genetic ancestry tools! Lot's of under-the-hood optimisation using python (zarr, dash), and it only takes VCF or BGEN input atm. github.com/PGScatalog/pgs…

Wish it was easier to calculate PGS in trusted research environments (TRE) like DNAnexus or the All of Us workbench? Us to! We've been hard at work on a new version of pgsc_calc to make it more scalable in those TREs! Introducing pgsc_calc v3.0.0-alpha.1: pgsc-calc.readthedocs.io/en/v3-alpha.1/

New paper in @ESC_Journals @sritchie73 & colleagues found integrating genetic & metabolic blood tests with existing clinical data could enhance how doctors identify people at high risk of heart disease, leading to earlier prevention strategies Read more: tinyurl.com/bp5tjck2

Today, we're celebrating a two-decade milestone: on November 5th, 2005, we broke ground at the Donnelly Centre! Thank you to everyone who has made Donnelly the building it is today!

🚨 Exciting new PhD Opportunity 🚨 Applications are open for 3-year non-clinical PhD studentships with the BHF Cambridge Centre of Research Excellence 📅 Apply by 23 Nov 2025 🌍 Open to UK & international applicants Find out how to apply here: tinyurl.com/3t59uwbn

"This study demonstrates that PRS, when incorporated into existing risk prediction frameworks, are unlikely to meaningfully exacerbate disparities in CVD risk stratification." medrxiv.org/content/10.110…

Algorithmic fairness metrics are increasingly used in AI/ML to assess model bias. A clever PhD student (@claireicoffey) suggested applying these methods to clinical risk prediction or polygenic risk scores. See our new preprint for the whole story : medrxiv.org/content/10.110…

@wilson_md @claireicoffey Thanks Mike! It feels like almost yesterday I was doing a PhD rotation with you… but maybe it’s been longer than that 🕰️

@iamslambert @claireicoffey Congratulations to both of you!

Congratulations @claireicoffey on passing your PhD viva (it's not everyday your first PhD student graduates)! It's been a pleasure to supervise your work applying algorithmic fairness techniques to risk prediction models and polygenic scores with Angela Wood & Mike Inouye.

📣 Thrilled to announce our collaborative tutorial with @EBItraining! Dive into the world of polygenic scores and explore the PGS Catalog resources (including pgsc_calc) - ideal for those seeking a comprehensive yet quick overview. Access it online at buff.ly/CEBWMio!

From @sangerinstitute and the CEU! Translating genetic changes into future health impact New resource helps bridge the gap between identifying genetic changes linked to health conditions & understanding how these changes impact biological processes 🔗tinyurl.com/3fs4prt3

New PhD studentship opportunities! The Cambridge BHF CRE will be funding non-clinical 3-year PhD studentships, with a hope to recruit people interested in interdisciplinary projects 👉For more information & how to apply please visit jobs.cam.ac.uk/job/49483/ 📅Apply by 16 Jan!

📢Fully-funded PhD studying the comorbidities of high adiposity. 🔗: jobs.cam.ac.uk/job/48333/ (2 weeks left, due November 20) Great work environment @CAMBRIDGE_CEU @HLRI_Cambridge, collab with @AstraZeneca @MikeXiao_JIANG @CambridgeATS. DM or e-mail for informal enquiries.

HELP! Which information would you like to see in @GWASCatalog regarding #ancestry? 📝 Fill out the survey (less than 1 min!) shorturl.at/kkCEZ 🗣️ Share with #gwas colleagues #OpenAccess #Diversity #FAIRprinciples

@DrWillWatson @UHN I see you’re already hooked on Tim Hortons (which I controversially consider the Canadian equivalent to Greggs)!

Nearing the end of my first week in @UHN Toronto General Hospital’s Advanced Heart Failure & Transplant department. Great people and a brilliant ethos on learning and teaching.

💥💥💥New preprint 💥💥💥on the EuPRI resource. Where we reconstruct the motifs for 34,736 RBPs and study their function and evolution. Joint work with @ProfTimHughes (Toronto), Matt Weirauch, @LXandR_, Deb Ray, Kaitlin Laverty and many more. More details to come