Kyle LaPenna, MD, PhD

Progress ✅ scholar.google.com/citations?user…

@WCM_CVRI and WCM Cardiology seek postdoctoral applicants with strong research backgrounds for 2 years of NIH T32 funded mentored research (basic to translational). Requirements: PhD, MD, or equivalent; US Citizen, Non-Citizen National, or Permanent Resident. Reply with questions

Stop by my poster today at #ACC26 “Loneliness and Quality of Life in HFpEF” 11AM in poster hall E to learn more about loneliness as a modifiable risk factor of quality of life for patients with HFpEF! cardiocaretoday.com/post/lonelines…

Hi Everyone - 🥸Here are all the 27 late breaking clinical trials presented at @ACCinTouch (ACC.26) with session number, day, time, and objective. 😱See you in NOLA: 👇👇👇

In Print @JACCJournals JACC: Advances! Our @hopkinsheart #HFpEF Program study of #frailty status, components of frailty, and associated outcomes in ambulatory HFpEF. Frailty Status Predicts Adverse Outcomes in Ambulatory Heart Failure With Preserved Ejection Fraction | JACC: Advances jacc.org/doi/10.1016/j.… Kudos to the entire team! @JohnsHopkinsDOM @jhu_coah @jvaishnavmd @vivekpjani @VirginiaSHahnMD

Among patients with atrial fibrillation at high risk for stroke and bleeding, left atrial appendage closure was not noninferior to medical therapy in reducing the risk of stroke, embolism, major bleeding, or death at 3 years. Full CLOSURE-AF trial results: nejm.org/doi/full/10.10… Editorial: Left Atrial Appendage Closure — Another Overused Method in Cardiology? nejm.org/doi/full/10.10…

Impact of heart failure on postoperative outcomes in bariatric surgery - Surgery for Obesity and Related Diseases soard.org/article/S1550-…

Life-Space Mobility in Heart Failure with Preserved Ejection Fraction sciencedirect.com/science/articl… @ParagGoyalMD @DylanMarshallMD

🧵1. HFpEF (heart failure w/ preserved ejection fraction) & MASLD (metabolic dysfunction-associated steatotic liver disease) are rising together with obesity/metabolic syndrome. Once siloed, now reflect shared systemic metabolic dysfunction driving disease in both heart & liver.

Able to finally reconnect in person with one of my mentors and friend. Dr. He gave me the opportunity of a lifetime to join her lab as a research technician prior to medical school. Will be forever grateful for her taking the chance and believing in me.

Considerations for the net prolongation of life with a durable LVAD first strategy in younger pts in need of Adv HF therapies Now in @JACCJournals #JACCHF Link: jacc.org/doi/10.1016/j.…

🔥Excited for the Phase 2 CADENCE trial results of sotatercept in Cpc-PH (due to HFpEF) as a Late-Breaking Clinical Trial at #ACC26! Topline data already released: met primary endpoint with significant PVR reduction. Huge shoutout to the incredible team behind this—promising step forward for this challenging group! ⭐️ @mardigomberg @jeanlucvachiery @MUSC_Cardiology @AlessiaUrbinati

Our new work on a kinase in adipocytes instigating tissue dysfunction and systemic insulin resistance led by Ankit Gilani

With the best CV aging investigators @MichaelGNanna and @ParagGoyalMD on the convergence of aging and CVD Thanks to @JACCJournals @CandiceSilvers1 Also - great account by Dr @hmkyale on aging and CVD ~ will summarize

Introducing our newest class of Cornell cardiology fellows! We are beyond excited to welcome this amazing group to our Cornell family! 🫀❤️🏆🎉⭐️🥇

Just published in @JCI_insight our new paradigm for AF induced cognitive dysfunction. #EPeeps #cardiotwitter Congrats to @pav_990 @ColumbiaMed @CU_Cardiology insight.jci.org/articles/view/…

In obese #HFpEF cohort, >1/3 had ⬇️ CI despite preserved EF (pts were older, had #AFib, ⬆️#NTproBNP); wet-cold had worse outcomes #RHC may reveal high-risk groups beyond contractility & guide therapy beyond #LVEF jacc.org/doi/10.1016/j.… #Hemodynamics #JACCHF @KSharmaMD

🔥 Big news from CADENCE — positive topline results hitting all the right notes. Targeting PH in heart failure may finally be finding its rhythm. 🫀🎵 @mardigomberg @jeanlucvachiery businesswire.com/news/home/2025…

A new paradigm for ion channel regulation! Geoffrey S. Pitt @geoffrey_pitt & team @WeillCornell @WCM_CVTI reveal FGF13 regulates cardiac sodium channels (no binding required) by affecting membrane cholesterol: jci.org/articles/view/… The figure shows cholesterol depletion reduces Nav1.5 fluorescence signal at intercalated discs in myocytes.

Celebrating our Acute Care for Elders (ACE) Unit PAs, Ingrid and Lori!

Dysregulated Protein s-Nitrosylation Promotes Nitrosative Stress and Disease Progression in Heart Failure With Preserved Ejection Fraction | Circulation Research ahajournals.org/doi/10.1161/CI…