Medchem toolbox

45 posts

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Medchem toolbox

Medchem toolbox

@mchem_toolbox

RT your synthetic work @mchem_toolbox if its operationally simple, broad, produces new/privileged cores. @[email protected] | Run by @SaayakH

Beigetreten Ekim 2022
479 Folgt92 Follower
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Medchem toolbox
Medchem toolbox@mchem_toolbox·
Synthetic medchem is heavily skewed with only a handful of reactions (ex. amidation) used towards making new molecules, mainly due to simplicity and ease of the reaction. New developments in synthetic chem is still under-used in the medchem community. This page will try to
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Medchem toolbox
Medchem toolbox@mchem_toolbox·
With growing availability of chiral boronic acid building blocks, this work can be impactful towards chiral medchem libraries! @J_A_C_S Stereospecific Acylative Suzuki–Miyaura Cross-Coupling: General Access to Optically Active α-Aryl Carbonyl Compounds pubs.acs.org/doi/10.1021/ja…
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Medchem toolbox
Medchem toolbox@mchem_toolbox·
Using air sensitive organometallic reagents require special handling/training, limiting it’s use and reliability. Check out this work- authors prepared air stable gels impregnated with RLi reagent-this can be the future! ⁦⁦⁦@ChemistryatYork⁩ nature.com/articles/s4155…
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Medchem toolbox
Medchem toolbox@mchem_toolbox·
Making unnatural amino acids is still tedious and lacks generality. Check out this work on- Towards Enantiomerically Pure Unnatural α-Amino Acids via Photoredox Catalytic 1,4-Additions to a Chiral Dehydroalanine pubs.acs.org/doi/10.1021/ac… Cool work @JOC_OL @hebusto
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Medchem toolbox
Medchem toolbox@mchem_toolbox·
"There is no one-size-fits-all fluorophore"-- well said! A cool read if you wanna learn about fluorophores in chemistry and biology. @naturemethods @rhodamine110 @jonathangrimm
Nature Methods@naturemethods

Are you curious about using organic dyes in your microscopy experiments but not sure where to start? This Perspective from @rhodamine110 and @jonathangrimm introduces readers to the world of dyes and their pros and cons for biological applications. nature.com/articles/s4159…

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Yulab
Yulab@YulabJin·
Explore the universe of Lactone scaffold as potential pioneers for drug molecules: accessing various ring size, topology by different C-H activation reactions. Our seventh reaction for lactones just appeared in JACS ASAP. The next one is even more surprising...
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Donohoe Group
Donohoe Group@DonohoeGroup·
You can read all about recent advances in the field of dearomative functionalisations of heteroarenes in our newest perspective, out now in @ChemicalScience! Congratulations to @Dr_Nik_K and Bruno 🎉 bitly.ws/wP2V
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