ALADDIN project

A next step toward protection against Ebola viruses 💡 Researchers have developed a bispecific nanobody-based therapeutic capable of neutralising multiple ebolavirus species. Read more 🔗: nature.com/articles/s4146…

Next up in our partner video presentations: @INLnano 🎥 In this video, PI Alar Ainla explains the role of #microfluidics in the ALADDIN project and the importance of diverse teams in solving challenges like tackling cancer. youtube.com/watch?v=8jpAiL… #EICPathfinder @EUeic

It's #WorldColorectalCancerDay 🌍 Still one of the most common and deadly cancers worldwide—but early detection, research & innovation can change outcomes. In ALADDIN, we study colorectal cancer to advance nanobody discovery and aim to contribute to more effective treatments👥

Last week, we had an exciting day of video recordings at the @SaludISCIII and Hospital Universitario Fundación Jiménez Díaz (@quironsalud) in Madrid, Spain 📹 We continue soon with our partner video presentations, stay tuned ⏰ #ALADDINproject #EICPathfinder

Introducing the Therapeutic Nanobody Profiler 🧬 Optimising developability is key to biotherapeutic design, but tools for antibodies don’t always translate to nanobodies. This manuscript presents an open-source tool to assess nanobody developability. nature.com/articles/s4200…

Our mission: to develop nanobodies for future cancer therapeutics in a way that is... 📈 More efficient 📍 More precise 🐁 More ethical ...than current options. Read more: aladdin-project.eu

We continue with our video series! 💫 Now we present the work of @HebrewU in the project. @DinaSchneidman describes how ALADDIN accelerates nanobody discovery, and how her team contributes to this mission with #AI and machine learning tools. 🤖 youtu.be/dSvm1XbdvnY @EUeic

Nanobody-based therapies have potential for neuropsychiatric disorders  🧠 Researchers developed nanobodies targeting the glycine receptor mGlyR, a key player in depression. Intranasal delivery produced rapid and lasting antidepressant effects in mice. nature.com/articles/s4146…

A clear overview of our project? Say no more! 🎬 Discover ALADDIN in motion through our presentation video, where we explain how we tackle the current hurdles of nanobody development with our integrated approach. Watch the animation in a couple of minutes! ▶️

From inspiration to innovation 🔍 ALADDIN draws inspiration from the humane immune system to support work towards advanced nanobody-based therapies. Via multidisciplinary collaboration, we reshape how nanobodies are discovered and engineered. aladdin-project.eu @EUeic

Meet the ALADDIN consortium through videos💡 We’re excited to present our partners through video interviews. In this first video, our project coordinator @lafdez_synbio @CNB_CSIC explains his team’s role & the potential impacts of the project. youtu.be/dGdPLKwuHas @EUeic

This study reports on the engineering of mucus-tethering bispecific nanobodies. 🔬 Results from preclinical models: 🫁 Increased retention in the airways 🐭Enhanced protection against influenza in mice 🐹 Reduced SARS-CoV-2 transmission in hamsters nature.com/articles/s4156…

Curious about ALADDIN, but only have a couple of minutes to spare? 👀 Discover our new motion graphic animation video to quickly learn how our project accelerates the discovery and preclinical validation of nanobodies. ▶️ Watch the video below!

Interdisciplinary expertise from across Europe & beyond 🌍 ALADDIN is a joint effort between 8 partner organisations: @CNB_CSIC @HebrewU @INLnano @liu_universitet @SaludISCIII @Hospital_FJD @InCellia @ZirkaInnotech Read about our consortium: aladdin-project.eu/consortium/

Ion channels are proteins controlling the flow of specific ions across cell membranes. They are implicated in diseases like cancer. 🔬 Targeting ion channels is challenging, but nanobodies can help, thanks to their precision and adaptability. 💡 pubs.rsc.org/en/content/art…

A paper including ALADDIN PI @GeorgiosLolas from @InCELLia as one of the authors 👏 The article presents an age- and generation-based mathematical model to improve the understanding of how metastases evolve. 🔬 Read the full article: sciencedirect.com/science/articl…

Take a glimpse into ALADDIN 🧞 How can nanobody discovery be made faster, more efficient, and smarter? Our new motion graphic video introduces the ALADDIN project and its mission to transform the discovery of monoclonal antibodies. Dive into our story below! 🎥

Happy International Day of Women and Girls in Science! Today, we promote the equal participation of women in STEM. Closing the gender gap is needed for R&I to change the world. ALADDIN counts on the efforts of brilliant women. We’re excited to present some of them to you! 💎

A new era of nanobody discovery 🚀 ALADDIN brings together multidisciplinary expertise to streamline the process: 🧬 Target identification 🧬 Nanobody discovery & optimisation 🧬 AI-analysis & mathematical modelling 🧬 Preclinical validation in vivo aladdin-project.eu

In ALADDIN, our mission is to accelerate nanobody discovery to eradicate cancer. We aim to contribute to more effective cancer treatment by developing new nanobodies and a streamlined platform for their discovery. worldcancerday.org #UnitedByUnique #WorldCancerDay

Today, on 4 February, we commemorate World Cancer Day. Cancer affects the lives of millions of people worldwide. Each person has their own unique story. This calls for a people-centred approach to treating cancer—there cannot be a one-size-fits-all solution.