Roberto Rossini

19 posts

Roberto Rossini

Roberto Rossini

@robomics

Postdoc at UiO developing tools for 3D genomics

Oslo Beigetreten Mayıs 2020
138 Folgt49 Follower
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Roberto Rossini
Roberto Rossini@robomics·
Happy to share our latest work! A big thanks to @jonnings for his support and supervision. Many thanks also to our collaborators for their invaluable comments and feedback @torognes, @AMathelier and Vipin Kumar.
Jonas Paulsen@jonnings

New preprint out! biorxiv.org/cgi/content/sh… MoDLE allows simulating HiC-like contacts generated by loop extrusion genome wide in a matter of minutes. Opens up for exploring underlying features of genome structure. Available on the command line. github.com/paulsengroup/m… @INC_COST

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Jonas Paulsen
Jonas Paulsen@jonnings·
Struggling with Hi-C data? Meet hictk: a new toolkit revolutionizing working with .hic and .cool files! Seamless interoperability for a range of file formats, and blazing-fast performance, 3D genomics has just gotten a lot easier. Developer: @robomics academic.oup.com/bioinformatics…
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Anthony Mathelier
Anthony Mathelier@AMathelier·
We're excited to share our manuscript describing COBIND, a novel tool for the identification of transcription factor co-binding patterns with non-negative matrix factorization biorxiv.org/content/10.110… 1/9
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Anthony Mathelier
Anthony Mathelier@AMathelier·
So happy to finally see the peer-reviewed version of our manuscript "Cis-regulatory mutations associate with transcriptional and post-transcriptional deregulation of gene regulatory programs in cancers" out. doi.org/10.1093/nar/gk…
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Anthony Mathelier
Anthony Mathelier@AMathelier·
Great to see the peer-reviewed version of this work now out. Thanks @jonnings @robomics for having us involved! And congrats again 👏 genomebiology.biomedcentral.com/articles/10.11…
Jonas Paulsen@jonnings

New preprint out! biorxiv.org/cgi/content/sh… MoDLE allows simulating HiC-like contacts generated by loop extrusion genome wide in a matter of minutes. Opens up for exploring underlying features of genome structure. Available on the command line. github.com/paulsengroup/m… @INC_COST

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Anders Sejr Hansen
Anders Sejr Hansen@Anders_S_Hansen·
(1/n) Excited to share preprint by @ViraatGoel @mileshuseyin We develop Region-Capture Micro-C (RCMC) By focusing on specific regions, we generate the deepest 3D genome maps thus far We see coalescence of enhancer and promoters into “microcompartments” biorxiv.org/content/10.110…
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Chakravarthi Kanduri
Chakravarthi Kanduri@KanduriC·
Out now in @GigaScience after substantial improvement since the first version: doi.org/10.1093/gigasc…. Improvements since the first version are briefly summarised in the 🧵
Chakravarthi Kanduri@KanduriC

AIRR ML: Did you know that baseline machine learning methods can perform well even when disease-associated signals are present in only 2 out of 100 000 receptors in diseased adaptive immune repertoires? Check our latest preprint: biorxiv.org/content/10.110… 1/10

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Anthony Mathelier
Anthony Mathelier@AMathelier·
Very happy to see the peer-reviewed version of this work out at …eneticsandchromatin.biomedcentral.com/articles/10.11… We performed expression-methylation quantitative trait loci in 19 cancer types and identified 13 TFs likely driving DNA methylation patterns around their TFBS in at least 2 cancer types 1/6
Anthony Mathelier@AMathelier

Our new preprint is out We found that pioneer TFs are associated with the modulation of DNA methylation patterns around their binding sites in cancer and immune cells across cancers Led by @RozaBLemma w/ @TF_82 E Martinsen @Vesselinka @ragnhildes1 @oddsgab biorxiv.org/content/10.110…

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Mariike Kuijjer
Mariike Kuijjer@mkuijjer·
𝗣𝗢𝗥𝗖𝗨𝗣𝗜𝗡𝗘 analyzes complex, genome-wide, patient-specific regulatory networks directly on the network's edge weights. It is our latest addition to the network zoo and now out on @biorxivpreprint doi.org/10.1101/2022.0…
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Jonas Paulsen
Jonas Paulsen@jonnings·
Fully funded PhD position in bioinformatics available in my group. Exciting project focusing on analyzing in-house Hi-C data to model 3D genome alterations in cancer. Please RT. Read more and apply here: jobbnorge.no/en/available-j… @biovitenskap @INC_COST
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@unioslo_bioinfo @AMathelier @UniOslo @UniOslo_MED @Oslounivsykehus @IvarGrytten @jonnings @biovitenskap