Sameer Segal

this is actually insane > be tech guy in australia > adopt cancer riddled rescue dog, months to live > not_going_to_give_you_up.mp4 > pay $3,000 to sequence her tumor DNA > feed it to ChatGPT and AlphaFold > zero background in biology > identify mutated proteins, match them to drug targets > design a custom mRNA cancer vaccine from scratch > genomics professor is “gobsmacked” that some puppy lover did this on his own > need ethics approval to administer it > red tape takes longer than designing the vaccine > 3 months, finally approved > drive 10 hours to get rosie her first injection > tumor halves > coat gets glossy again > dog is alive and happy > professor: “if we can do this for a dog, why aren’t we rolling this out to humans?” one man with a chatbot, and $3,000 just outperformed the entire pharmaceutical discovery pipeline. we are going to cure so many diseases. I dont think people realize how good things are going to get

NDM '25. Missed a brag-milestone by a whisker, but kept Father Time at bay with a 6 min PB. Most gratifying was to see dear friends realise long- cherished dreams. Fun weekend.

Every technical founder who had stopped coding 10 years ago

When mechanical watches became obsolete around 1970 they represented almost exactly 700 years of refinement by some of the best minds of their time. That is a really long run.

A lot of people quote tweeted this as 1 year anniversary of vibe coding. Some retrospective - I've had a Twitter account for 17 years now (omg) and I still can't predict my tweet engagement basically at all. This was a shower of thoughts throwaway tweet that I just fired off without thinking but somehow it minted a fitting name at the right moment for something that a lot of people were feeling at the same time, so here we are: vibe coding is now mentioned on my Wikipedia as a major memetic "contribution" and even its article is longer. lol The one thing I'd add is that at the time, LLM capability was low enough that you'd mostly use vibe coding for fun throwaway projects, demos and explorations. It was good fun and it almost worked. Today (1 year later), programming via LLM agents is increasingly becoming a default workflow for professionals, except with more oversight and scrutiny. The goal is to claim the leverage from the use of agents but without any compromise on the quality of the software. Many people have tried to come up with a better name for this to differentiate it from vibe coding, personally my current favorite "agentic engineering": - "agentic" because the new default is that you are not writing the code directly 99% of the time, you are orchestrating agents who do and acting as oversight. - "engineering" to emphasize that there is an art & science and expertise to it. It's something you can learn and become better at, with its own depth of a different kind. In 2026, we're likely to see continued improvements on both the model layer and the new agent layer. I feel excited about the product of the two and another year of progress.