David Schopfer, MD

@tmodarressi These are not primary prevention patients. Prior CABG? Multivessel PCI? Diabetes with retinopathy? Multiple vascular bed involvement? These patients are sicker than in FOURIER.

VESALIUS a star of this lipid session at #AHA25. Substantial and deeply clinically meaningful benefit w Repatha in primary prevention. Baseline LDL-C 122. Notable ARRs, and 20% decrease in all-cause mortality! #AHA25

@khurramn1 Agreed. These patients are Not primary prevention and had extensive and severe disease. Arguably sicker and higher risk than the original FOURIER cohort.

I think we should be providing a disclaimer “very high risk” 33% had prior coronary revasc, 10% severe carotid disease or revasc, and 10% demonstrated PAD. It’s not a primary prevention trial

@drpablocorral These are not primary prevention patients. Inclusion criteria so strict most of these had more severe atherosclerotic disease than in FOURIER.

🚨 New breakthrough in prevention! 👉In the VESALIUS‑CV trial, Evolocumab added to high-intensity statin therapy reduced major adverse cardiovascular events (MACE) by 25% (HR 0.75; 95% CI 0.65-0.86) over ~4.6 years in patients who had no prior MI or stroke. 👉Absolute risk reductions: • ~1.8% for death from coronary disease, MI, or stroke. • ~2.8% when adding ischemia-driven revascularisation. 👉LDL-C fell ~55% to ~45 mg/dL—highlighting once again that “lower is better”, even before a first event. ☝️What this means for clinical practice: • This is the first PCSK9 inhibitor trial showing benefit in a “pre–first event” high-risk population, not just secondary prevention. • Identifying high-risk patients (e.g., established atherosclerosis, high-risk diabetes) before MI or stroke is crucial. • This supports aggressive LDL-C lowering to ~40 mg/dL in selected patients—even without prior event history. ☝️Take-home: For the right high-risk patient, adding evolocumab before the first major cardiovascular event can be a game-changer. Traditional prevention meets cutting-edge therapy. @society_eas nejm.org/doi/full/10.10…

@MaxBretosSports Bird in the hand. I think you always take the goal over red card and hope you get a goal later.

Interesting situation.. you obviously take the advantage and goal, but free kick and red card to Leon Bailey might be after 90 mins better route to win!! 🤔

@mnolangray Oakland

What's the most underrated city in California?

Serious question: Why on earth should Manchin be in charge of the Senate Energy and Natural Resources Committee? He’s taken more money from fossil fuel sources than any other member of Congress, including every Republican. Hello?

Big Pharma says they need to charge astronomical prices to pay for research and development. Yet, the amount they spend on manipulating the market to enrich shareholders completely eclipses what's spent on R&D. Today, I confronted a CEO about the industry's lies, with visuals ⤵️

McConnell: "We can't consider impeachment before Trump leaves office." McConnell: "We can't consider impeachment because Trump already left office."

NHLBI announced upcoming research opportunities to investigate post-acute sequelae of COVID-19 (aka "Long COVID") in people who were infected and are suffering a variety of symptoms. Solicitations for research forthcoming. covid19.nih.gov/sites/default/…

@OpenMCPS The lack of science in their decision-making is appalling. Schools all over are doing it well and proving it is possible.

Seems like state teachers' union has their own plans for return to school despite the prioritization of teachers for vaccine distribution. "Bost says late summer or early fall may be a more realistic time frame." wcbcradio.com/?news=hogan-no…

@tesla_raj @elonmusk @p_ferragu Once FSD goes to monthly subscription, it will essentially be transferable. Since you'll be paying as you go for whatever car you have. Right?

@elonmusk @p_ferragu Also an option to transfer our FSD to our next car would be perfect. I’d buy a Model Y today!

@elonmusk: I paid FSD for my Model 3 in November. I now want to upgrade to model Y and your team tells me you don't value FSD in your trade-in offer because you can do the software upgrade for free. Want me to pay again full price for FSD again? That's not fair, change that!

@BethesdaBeat MCPS is not opening this school year, much less next month. The metrics they have set are WAY BEYOND what we can reach any time soon. Fingers crossed for September, but that is no guarantee either.

Absent an unexpected reversal of the worsening COVID-19 data, or a change to the metrics set to guide MCPS reopening, buildings will likely not reopen as planned next month. ow.ly/F7fH50D1YHc

Pipe bombs found and destroyed at headquarters of RNC and DNC. Is that a 1st amendment right? Is this officially considered a coup attempt yet?

We do a better job protecting confederate statues than we do the Capitol Building.

In America, you can be teargassed and shot with rubber bullets for peacefully protesting in front of a church. But you can literally bust down the doors to the United States Capitol and stroll around while police officers watch.

Stop sharing the McConnell quote from 2016 about "The American People" having a voice in picking a new SCOTUS Justice. Just stop it. He doesn't care. He didn't care then, he sure as fuck doesn't care now. He's a traitor. He feels no shame, no pity, nothing. End the GOP.

That day when a little girl from Oaktown became the first black woman to be a major-party vice-presidential nominee...😭 So incredibly proud of you, sis! ❤️🤍💙

A medical group known as conservative and cautious has a clear message: Get kids back into classrooms this fall, even if 6 feet of distance can't be maintained. Dr. Sean O'Leary explains why.  nyti.ms/2YRfxbd

Absolutely dominant

LIVERPOOL HAVE WAITED 30 YEARS FOR THIS MOMENT! THEY ARE PREMIER LEAGUE CHAMPIONS 🏆