Bonev Lab

🚨New Preprint 🚨: What are the key epigenetic mechanisms that drive species-specific gene regulation during primate neurogenesis — and how do they contribute to the evolution of the human neocortex? Curious? 👇 biorxiv.org/content/10.110… Led by Silvia Vangelisti @sinsy_ and Boyan

Congratulations, Jei! 🎉 We’re so proud of your journey and all that you’ve achieved. Thank you for all your incredible contributions! 🎓

This was a great collaboration between the @BonevLab and the Tanay Lab, led by @yonatan1shapira and @FNoack86 with substantial contribution from @sinsy_, @fayeeeC_ and @aviezer_l. If you found this study of interest, please RT, comment and share! All feedback is welcome. 14/14

Code and data to reproduce all figures, or browse and reanalyze, is available at github.com/tanaylab/mmcor…, either separately or in a standalone docker container. You can also explore the data interactively at apps.tanaylab.com/MCV/mmcortex/. 13/14

Can a stem cell change its epigenome while proliferating? In our new preprint, in collaboration with the Tanay Lab, we demonstrate that the epigenome of neural stem cells is continuously remodeled, across multiple layers, during mouse corticogenesis. 1/14 biorxiv.org/content/10.110…

Very happy to share the preprint of my main PhD project in the @Bonev_Lab! Huge thanks to Boyan, all co-authors and members of the @Bonev_Lab. This work wouldn’t have been possible without your contributions!

This study was led by @sinsy_, with contributions from @fayeeeC_ , Tamina Dietl, Sebastian Diecke, and Wolfgang Enard — a great collaboration with @EnardHellmannWG ! Congrats to all!

7/7 By combining multi-omic profiling with state-of-the-art computational analysis, we link 3D epigenome evolution to transcriptomic changes in primate brain development, revealing how divergent regulatory networks and epigenome dynamics contribute to human brain evolution.

🚨New Preprint 🚨: What are the key epigenetic mechanisms that drive species-specific gene regulation during primate neurogenesis — and how do they contribute to the evolution of the human neocortex? Curious? 👇 biorxiv.org/content/10.110… Led by Silvia Vangelisti @sinsy_ and Boyan