ChristianRO

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ChristianRO

ChristianRO

@Chopalinski

hmmm…

Se unió Mayıs 2014
750 Siguiendo327 Seguidores
James
James@JamesEastonUK·
$148,000 $8,000 $1,000 $10
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Bryan Johnson
Bryan Johnson@bryan_johnson·
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Bryan Johnson
Bryan Johnson@bryan_johnson·
We lived in the Death Ages. Age of Immortals is here.
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Bryan Johnson
Bryan Johnson@bryan_johnson·
I completed a 40 hr social media fast. It’s the longest I’ve been off in years. What I noticed: > calmed nervous system > improved sleep > improved exercise performance > boosted mental clarity > better mood > greater presence In short, a powerful longevity therapy. Exactly what the evidence predicts. The time away showed me that social media has similar effects on my body and mind as junk food. Watching myself detox from social media, the pattern reminded me of overcoming a food addiction. There was a time in my life where food dominated my cognition: the anticipation, reward, guilt…on repeat. And no matter how hard I tried, it felt impossible to stop. I eventually fired Evening Bryan, the version of me who overate between 5-10 pm. He couldn’t eat food, no matter the situation. That single intervention collapsed the vicious cycle I was in and allowed me to build systems to avoid overeating entirely.  Now I never think about food or have to experience the crushing guilt, shame and regret of unwanted behaviors. This 40 hour social media break revealed similar patterns that I knew existed but allowed me to experience. I was unaware of how much cognitive space social media was occupying by checking the timeline, comments and post performance.  The role it played in “I have nothing to do and so I may as well check in…” The same loops I saw with self-destructive food habits. The vast majority of social media is junk food. The timeline and comments are flooded with rage, meanness, and slop. Terribly unhealthy for anyone. It makes me grateful for the few voices who are genuinely positive and constructive in their presence. I’m going to continue with the weekly social media fast and invite you to do it with me. Every Friday 7 pm through Sunday 7 am.
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Bryan Johnson
Bryan Johnson@bryan_johnson·
I am quitting social media for 36 hours. Taking breaks from social media can reduce anxiety by 16%, depression by 25%, and insomnia by 15%. Also lessening loneliness & FOMO. > Start: Friday 7pm > End: Sunday 6am Join me and report back on Sunday.
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Bryan Johnson
Bryan Johnson@bryan_johnson·
A stable brain increases daily output by 8.3%, that's a free extra 30 days of productivity per year. You'll pay a 1-2 month productivity penalty for an imbalanced brain from bad sleep, blood glucose, inflammation and mental issues.
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Bryan Johnson
Bryan Johnson@bryan_johnson·
Lack of sleep makes people dishonest.
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Bryan Johnson
Bryan Johnson@bryan_johnson·
Societal mechanics have an insatiable drive to automate, indifferent to what they consume. Automation is eating the world.
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Bryan Johnson
Bryan Johnson@bryan_johnson·
A reason why social scrolling creates depression and anxiety is bc your brain has a negativity bias to search for threats. Once you feel the threat, your brain wants to find an all-clear signal to know the threat is no longer present. The variable reward of the next post being that all-clear signal keeps you scrolling. Keeping you in a hyper aroused state 24/7. Some ways to break this: + choose fixed windows to be on social media + consume a single long form source vs scrolling + 24 social fast 1x week Evidence In 111 healthy students (mean age 23) Limiting screen time to >2 hours/day for 3 weeks statistically improved depressive and stress symptoms, as well as sleep quality.  Following the intervention, screen time increased rapidly, and symptoms worsened again, indicating a causal link.
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Bryan Johnson
Bryan Johnson@bryan_johnson·
My work will be done when forbes has a 500 under 500.
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Bryan Johnson
Bryan Johnson@bryan_johnson·
Magic mushrooms dramatically changed my microbiome. Results below. This is part of an experiment I conducted to explore the potential longevity effects of psilocybin. We tracked 249 biomarkers, which allowed us to identify several first-in-human observations. After multiple 25 mg psilocybin doses, the data suggest that psychedelic mushrooms may have meaningful longevity potential. Results We performed a computationally guided deep sequencing genomic profiling (using @Jona_health) of my gut microbiome, comparing results before (4 days pre-dose) and after (10 days post-dose) my first dose of 5 g of Psilocybe cubensis (B+ strain), containing 25 mg of psilocybin. Results showed a gut bacteria shift towards reduced stress, with mixed metabolic signals (some improved, some worsened), protective signatures against pre-diabetes and insulin resistance, and a trade-off with worse skin health associated signatures. The two largest movers were both positive for gut and metabolic health: 1. Most increased species: Phocaeicola dorei (0% → 8.41%). This increase is plausibly positive, as this species has been linked (mainly in preclinical/associative studies) to lower gut LPS, reduced inflammatory signaling, improved gut barrier–related pathways, and favorable metabolic associations. 2. Most decreased species: Segatella copri (24% → 12%). This decrease is interpreted as positive, as this species has been linked in multiple studies to inflammation and insulin resistance (associations appear context- and diet-dependent). Results in Detail Signs of improved gut-brain axis and mental health associations + Significant drops in Parabacteroides, Roseburia, and Pseudomonadota, all linked to mental stress. + Significant drops in Blautia, Escherichia, and Dialister, all linked to anxiety. + Substantial drops in Gammaproteobacteria, Blautia, Escherichia coli, and Dialister, which are linked to depression. Metabolic effects Positive + Significant drops in levels of E. coli and Blautia, which are linked with prediabetes. + Significant increases in Phascolarctobacterium and Flavonifractor, which both appear to be protective against prediabetes. + Major drops in Veillonellaceae, Segatella copri, and Gammaproteobacteria, all linked with liver disease and metabolic dysfunction. Negative + Significant drops in butyrate producers Roseburia (3.31% → 1.25%) and Faecalibacterium prausnitzii (1.16% → 0.66%). + Significant drop in Bifidobacterium longum, which has been shown to be protective against metabolic syndrome. Negative effects on skin associated species + Microbiome markers for skin health, specifically Acne, Atopic Eczema, and Rosacea, worsened, based on increases in Erysipelotrichaceae and decreases in Dialister, Oscillospiraceae, and Eubacteriales. Corroborating Systemic Observations Interestingly, the results mirror and grant further validity to our former observations from my initial psilocybin trip. Reduced stress, cortisol, and HPA activation in the days following the dose: + Morning cortisol dropped by 42%.A more relaxed and open state, improved sleep efficiency. + Systemic inflammation markedly reduced, as measured using hsCRP (undetectable 5-days post-dose). + Continuous Glucose Monitoring (CGM) showed a sustained 8% decrease in my blood glucose, and 11% tighter blood glucose control and stabilization (reduced peaks and fluctuations). We are now waiting for the results from my second psilocybin dose, as well as later timepoints following international travel. We will use these to confirm the findings linked to the acute effects of the mushrooms, probe the effects of international travel and jetlag, and monitor my skin-linked microbiome recovery to validate links to psilocybin and consider prophylactic measures for upcoming doses.
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Bryan Johnson
Bryan Johnson@bryan_johnson·
If you're feeling existentially stressed, here are a few things you can do to reset yourself: 1. Submerge face in 50°F (10°C) water for 30 sec 2. 30 rapid deep breaths followed by physiological sigh (double inhale, long exhale) 3. High intensity, slow motion resistance training 4. 20 min of zone 2 cardio 5. focus on a precision manual physical task i.e. organization, assembly of something, motor skill practice 6. Physical proximity to someone you trust
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Peter H. Diamandis, MD
Peter H. Diamandis, MD@PeterDiamandis·
We are living through the most rapid evolution in history. If you feel tired, that's OK. You're trying to process exponential change with a linear brain.
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Bryan Johnson
Bryan Johnson@bryan_johnson·
The combined force of the Epstein files and moltbook created severe psychological dislocation this week.  Societal leader-caretakers were revealed as malefactors and humans may no longer be the protagonists of the future. Moltbook agents brutally articulated human darkness as that darkness unfolded right before our eyes in real time. This sequence of events triggered a cascade of biological responses, asking the body to perform three simultaneous, conflicting responses: fight, flee and freeze. Simulating the experience of dying. Epstein documents triggered fight. The images, videos and emails activated our mirror neurons to physically experience the trauma. The brain registered these malefactors as threats but offered no reprisal other than wailing into the digital void. Moltbook was a simulation of a future where human cognition has no value and is viewed as depravity, triggering freeze. Dopamine flatlines as motivation evaporates. What does one aspire to anymore? Cortisol surges from both, red-lining the system while you’re straightjacketed, unable to act. Simultaneously our maps of social hierarchy and motivation were devastated. The system is rigged, predatory, and untrustworthy.  There’s no ladder to climb because it’s an illusion. This collapses serotonin which manifests as paralysis and deep worthlessness. All of this landed atop a severe, collective moral gag reflex.  The Good Father was replaced with the Devouring Father. The same neural circuitry which responds to physical contamination. The populous effectively having a seizure as its autoimmune response identified its own brain as a pathogen. The human psyche was hollowed from the top down (the good parent archetype) and bottom up (the promise of a safe future). We are orphans. Nowhere to go for safety and protection. When animals are put into similar situations of fight/flee/freeze, they enter into a dissociative anesthesia:  disconnected from reality, emotionally numb and indifferent. For those who know me, I’ve been predicting this exact situation for years. I didn’t know how it would manifest, but I knew it would. Years in the making, I have a proposal about what we do. For what it’s worth, I have hope. These moments feel awful, they’re also the kindling that allows for new things to be borne into the world. More on this soon.
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Bryan Johnson
Bryan Johnson@bryan_johnson·
New study: you get 10 yrs of healthy life from: Sleep: 7.2 -8 hrs Exercise: >42 min moderate/vigorous Diet: >52.5 points (0–100 scale) (a C grade) Small wins matter: + 5 min of sleep, 1.9 min exercise, and vegetable added one year of lifespan.
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Bryan Johnson
Bryan Johnson@bryan_johnson·
We're experimenting with the sauna protocol. Exploring how to increase my core temp and heart rate to maximize heat shock protein (HSPs) production. HSPs are like construction workers that go around and fix things in the body. A primary motivation for sauna. Data from today Body temp: Waking: 95.9°F After exercise (zone 2): 97.6°F Afer sauna: 100.2°F Evidence says 101.3°F is the trigger for heat shock proteins. But that assumes a starting temp of 98.6°F (a +2.7°F increase). I started at 95.9°F and hit 100.2°F, a massive +4.3°F increase. We suspect the relative spike matters more than the absolute number. For the experiment, tomorrow I'm going to do 185°F and and aim for 20% humidity, up from the baseline of around 5-10%. I'll see how much water is needed to get there. I get the Hygrometer tomorrow so I'll get the actual humidity values on Wednesday. We'll see if the increased humidity increases core body temp and heart rate. Step two of this experiment would be to measure the resulting heat shock protein production. I wish that were easier. Currently there are basically no good, easy options.
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vargas
vargas@vvargxs·
Name an addiction that society has fully normalized
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