David P. Labbé, PhD

Thrilled to share our study in @CR_AACR! #Obesogenic high-fat diet (HFD) and #MYC cooperate to promote lactate accumulation and TME remodeling in #prostatecancer. Co-first authors @BoufNadia and Paolo Chetta. Co-lead @ZadraGiorgia + 30 co-authors! bit.ly/3yUNID3 (1/17)

@PingMu_PhD Congrats Ping!

New Urologic Sciences Division Bridges Research and Clinical Excellence m.yale.edu/dgn2

@cusm_muhc @McGillMed @PCF_Science @urotoday @UrologySBUR @TheAACU @Uroweb

🚨 Exciting leadership opportunity at @McGillU / @MUHC: Associate/Full Professor (Clinical) to serve as Director of the Division of #Urology & Director of #Urology at the MUHC (@McGillDeptSurg). Apply here: bit.ly/4bCZNhS Please RT/share and come join us in Montréal🇨🇦!

🚨 New Review in Gene! Therapy-Induced Senescence in Prostate Cancer ✔ Mechanisms & biomarkers ✔ Dual role of TIS: tumor-suppressive vs. tumor-promoting ✔ Senolytics & senomorphics as next-gen strategies ✔ Clinical trials & future directions 🔗 doi.org/10.1016/j.gene…

We are hiring a 👩‍🔬 Research Assistant 👨‍🔬 to work on cutting-edge dietary interventions to potentiate DNA damaging therapies in prostate cancer. Come working with us at the @CUSM_MUHC @McGillDeptSurg @mcgillu! Please share: bit.ly/43V72fs @UrologySBUR @PCF_Science

It is an honour to be listed among this list of outstanding prostate cancer scientists! @mcgillu @RIMUHC1 @McGillDeptSurg @MUHCFoundation @CedarsCancer

@PingMu_PhD @Yale_Urology @YaleMed @YaleCancer @Yale Congrats Ping and welcome back to the ET time zone!!!

Super excited to share that we’ve moved to Yale University’s Department of Urology to continue our prostate cancer research. Already loving the Yale community and looking forward to some awesome collaborations ahead. @Yale_Urology @YaleMed @YaleCancer @Yale

It was a pleasure to meet and discuss research with like-minded scientists on a mission to make a difference for patients with urological diseases at the #URS2024 meeting hosted at @YaleMed! Thanks for the invitation and the great time!

@PingMu_PhD This is a very good one! Congrats on getting there (I talk from 1 extra year of experience)!

Can officially use this mug now 😆

Obesogenic High-Fat Diet and MYC Cooperate to Promote Lactate Accumulation and Tumor Microenvironment Remodeling in Prostate Cancer out on @CR_AACR aacrjournals.org/cancerres/arti… Study explores how systemic metabolism, particularly through a high-fat diet (HFD) rich in saturated fats, accelerates c-MYC-driven #ProstateCancer progression by rewiring tumor metabolism. In a mouse model🐭the combination of c-MYC🧬 activation and an obesogenic HFD led to increased glycolysis and lactate accumulation in tumors, which promoted immune changes, including higher infiltration of tumor-associated macrophages and regulatory T cells. These alterations contributed to tumor growth, therapy resistance, and angiogenesis, which were reduced by lactate dehydrogenase inhibition. Clinical data🥼 revealed similar tumor metabolic shifts in prostate cancer patients with high saturated fat intake, suggesting lactate's potential as a biomarker and target for dietary and therapeutic interventions in advanced prostate cancer. @RIMUHC1 @BoufNadia @Carole_Luthold @eddieimada of @WCMCPathology @Davicioni @DrSpratticus Lisa M. Butler of @UniofAdelaide Massimo Loda of @WeillCornell @DavidP_Labbe @ZadraGiorgia

Thanks to the Marathon of Hope Cancer Centres Network for this outstanding opportunity to help improve the efficacy of prostate cancer treatments through lifestyle interventions!

@ThePennLab @alannahskye23 @PMResearch_UHN @UofT Congrats Alannah and the Penn lab!!!

👏🥳Congrats to Alannah MacDonald, PhD student from my lab and Dr. Brian Raught’s lab, for her 4th place poster award at the MYC Conference in Stockholm! @alannahskye23 #science #research #MYC

Drs. @DavidP_Labbe & @ZadraGiorgia's team, led by Drs. @BoufNadia & Paolo Chetta, showed that an obesogenic high fat diet 🍟 🍔 rich in saturated fats promotes the development of c-MYC–driven invasive #ProstateCancer through metabolic rewiring. @RIMUHC1 bit.ly/45ySQcu

@kazaklab @Parklabmcgillu @thomas_duchaine @McGillGCI @mcgillu Congratulations Lawrence, this is very well deserved! 🍾

Tenured. Thanks to all Kazak lab members - past and present - for their hard work, curiosity, and trust in the scientific process. Thanks to @Parklabmcgillu and @thomas_duchaine for their leadership. And thanks to the anonymous letter writers. @McGillGCI @mcgillu

@MariannKruithof Thanks Marianna! ☺️

@AdamSharpMedOnc @CR_AACR @BoufNadia @ZadraGiorgia Thanks Adam! Hopefully this will provide additional rationale to capture lifestyle / diet data in the clinic so that we can really delve into an era of precision nutrition in prostate cancer prevention, detection and treatment.

@DavidP_Labbe @CR_AACR @BoufNadia @ZadraGiorgia You work on some cool and tough stuff. Congratulations 🙌

Thrilled to share our study in @CR_AACR! #Obesogenic high-fat diet (HFD) and #MYC cooperate to promote lactate accumulation and TME remodeling in #prostatecancer. Co-first authors @BoufNadia and Paolo Chetta. Co-lead @ZadraGiorgia + 30 co-authors! bit.ly/3yUNID3 (1/17)

@MariannKruithof @CR_AACR @BoufNadia @ZadraGiorgia Thanks Marianna!

@DanielFrigo @ZadraGiorgia @BoufNadia You did! It is an honor to have our work covered by your thorough and insightful comment, thank you!

Hope I did it justice @DavidP_Labbe @ZadraGiorgia @BoufNadia! It was a great study that I think could have important implications for the way we interpret how & when modifiable risk factors could impact #prostatecancer.

Funds: @PCF_Science @CIHR_IRSC @FRQS1 @CUSM_MUHC @McGillDeptSurg @UrologySBUR @mcgillu @McGillMed @cancersociety @McGillGCI @SRC_CRS @MUHCFoundation @foundation_hgm @CedarsCancer

Thanks to co-authors for doing the work, reviewers and the editor @CR_AACR for helping improve our work and funders to have made this work possible! Co-authors on Twitter: @annadepolo84 @Carole_Luthold @Davicioni @DrSpratticus @drleighellis @BordeleauLab @MassimoLodaMD (17/17)

Deconvolution models uncovered ⬆️ proportion of M2-like macrophages in ⬆️ glycolytic prostate cancer from patients with ⬆️ saturated fat intake. This strongly suggests that acquisition of glycolytic features contributes to shaping a TME supportive of cancer progression. (11/17)