HarbauerLab

Excited to share this recent preprint from the @MickLab. They cleverly join APEX-proximity biotinylation, which usually requires exogenous addition of H2O2, with D-aminacid-induced local H2O2 production by expression of the yeast DAO. It's genious! biorxiv.org/content/10.110…

🚨Opportunity Alert! 🧠Apply now for our fully funded #PhD Positions in #Neuroscience & #Translational #Psychiatry 📝at applications.imprs-tp.mpg.de ⌛️until 31. Oct ℹ️imprs-tp.mpg.de/3041/instructi… ❓ imprs-tp.mpg.de/97967/FAQs 🔃 Please share/retweet #PhDposition #hiring #Job #research

We are thrilled to announce the first #Munich Postdoc Night on Sept. 12th @badw_muenchen! Talk about your research with peers from different institutions and disciplines in Munich! Register until July 21st to present a poster at the event! munich-postdoc-network.mpg.de/40263/Munich-P…

Ribosome-Associated Vesicles promote activity-dependent local translation biorxiv.org/content/10.110…

Pink surfin’ on the ER – The ER plays an active role in the biogenesis of the #Parkinson protein PINK1 in stabilizing its precursor on its way to #mitochondria in neurons. #mitophagy New preprint from my lab! biorxiv.org/content/10.110…

Please register to get an update on cellular imaging by light and electron microscopy. And of course, to meet friends and make new friends 🤩 #microscopy #cellbiology

Use for free access to the paper rdcu.be/dBJUC or visit doi.org/10.1038/s42255…

This goes awry in neurons that have lost their ability to respond to insulin, e.g. upon treatment with the #Alzheimers disease (AD) risk factor ApoE4. This connects two phenomena commonly seen in AD, damaged mitochondria and #insulin resistance.

Molecularly, the Pink1 mRNA tethering complex is phosphorylated by #AMPK to keep the amount of PINK1-mediated mitophagy low. Only upon untethering, e.g. upon inactivation of AMPK by insulin signaling, can mitophagy process and the neuron take care of damaged mitochondria.

Tabitha identified a molecular switch that allows neurons to turn #mitophagy on and off, by tethering the Pink1 mRNA to mitochondria. This protects #mitochondria in neurons from being used as a simple nutrient source, because we all know they are much more important than that!

Could not be more proud to share the story one of my first PhD students in the lab. Shout out to Tabitha! For more info and links see below.

In a new study, @HarbauerL found that insulin supports the recycling of dysfunctional mitochondria in neurons. Energy scarcity or interrupted insulin signals can lead to the continued use of defective mitochondria, which might affect neurodegenerative diseases. Read more: bi.mpg.de/news/2024-03-h…

Amidst our focus on sustainability, digitalization, cybersecurity, and AI, it's crucial to ensure that research, skills, ideas, and the workforce are equally accessible. Remember, girls represent half of tomorrow's world — let's not leave them behind! #WomenAndGirlsInScienceDay

Cool story on how local translation shapes mitochondria: FMRP granules drive mitochondrial fission via local translation in neurons: Biophysical Journal cell.com/biophysj/fullt…

The long anticipated preprint is here! Most axonal mitochondria in cortical pyramidal neurons lack mitochondrial DNA and consume ATP biorxiv.org/content/10.110…

@HarbauerL we're looking forward to your presentation at #MCS24 in Mexico this February! 🇲🇽☀️ Please RT to let your followers know you'll be speaking, and that Early Bird & Talk Submission deadlines close this Thursday (30 Nov 2023). Find out more➡️bit.ly/3N5rq66

🚨In 1 week! Join us at the @mito911_ series for @HarbauerL talk on #mitochondrial #health maintenance in #neurons!

So, luck nature.com/articles/s4146…