Ivanov lab

Excited to share the lab's first preprint ! We previously observed CD226+ macrophages in brown fat that resemble CCR2- and IRF4-dependent peritoneal small Macs, but we didn't know anything about them... biorxiv.org/content/10.110…

This novel macrophage population in salivary glands is regulated by ILC-2 derived GM-CSF and arises mostly from MDP-derived monocytes. Importantly, they also express CD226+ and have a lot in common with the population we describe in adipose tissue... More to come !

Happy to see this paper out @NatImmunol ! To read it : rdcu.be/eX0JB Great collaboration with the Becher lab @UZH_en. @AlexGallerand @LP2M_Lab @Univ_CotedAzur @CNRS_DR20

CSF1R signalling sustains glucose uptake in Ly6Chigh monocytes to fuel the hexosamine biosynthetic pathway (HBP), which in turn allows optimal CSF1R expression. Impairing glucose flux towards HBP through GFPT1 invalidation leads to increased Ly6Chigh/Ly6Clow ratio.

We report that surface CSF1R expression relies on continuous translation and export to the membrane. CSF1R recycling rate accelerates as monocytes differentiate from the Ly6Chigh to the Ly6Clow subset, and CSF1R blockade prevents Ly6Chigh commitment towards this trajectory.

CSF1R regulates monocyte subset differentiation and intracellular metabolism. biorxiv.org/content/10.110… Our new preprint is now online ! Here, we explore links between CSF1R signalling, intracellular metabolism and monocyte differentiation.@LP2M_Lab @Cnrs20 @Univ_CotedAzur @Inserm

nature.com/articles/s4200… A great work by the Williams lab! Thank you for the collaboration. More to come :) @Lab__Williams @LP2M_Lab @CNRSbiologie @Cnrs20 @Inserm @Univ_CotedAzur

Congrats @LettieriBarbato and team for their recent publication on brown adipose tissue macrophages, happy to have been involved in the project ! @LP2M_Lab @CNRSbiologie @Univ_CotedAzur @Lab__Williams nature.com/articles/s4146…

Excited to share the lab's first preprint ! We previously observed CD226+ macrophages in brown fat that resemble CCR2- and IRF4-dependent peritoneal small Macs, but we didn't know anything about them... biorxiv.org/content/10.110…

Happy to see this study published in @HEP_Journal, resulting from a great collaboration with Philippe Gual @C3M_U1065 @LP2M_Lab @CNRS_DR20 @Inserm @Univ_CotedAzur with contribution from @Lab__Williams @AlexGallerand @Bastien_Dolfi journals.lww.com/hep/abstract/9…

Thanks to team members and key collaborators @AlexGallerand @adeline_bertola @maxim_artyomov @Bastien_Dolfi @DavidMASSON14 @FGinhoux @lab_mass @Lab__Williams and all other people involved !

We report that this subset is conserved across several tissues and especially fat, in which they regulate lipid metabolism. Importantly, these cells have a rapid turnover from monocytes, and in particular MDP-derived monocytes that are biased to differentiate into CD226+ Macs !

Happy to see our review on macrophages of the vascular system published in Nature Cardiovascular Research ! ⁦@GwenRandolph_⁩ ⁦@jichang_han⁩ @IvanovLab nature.com/articles/s4416…

🚨preprint alert! Identification of conserved and tissue-restricted transcriptional profiles for lipid associated macrophages (LAMs) biorxiv.org/content/10.110…

Ivanov lab paper ! Very happy to see our story on monocyte glucose metabolism online in ⁦@NatureComms⁩ today. Inhibition of Glut1 depletes the majority of blood monocytes, yet atherosclerotic plaques still develop normally🧐 ⁦⁦@LP2M_Lab⁩ nature.com/articles/s4146…

Happy to see this story out! @LP2M_Lab @Univ_CotedAzur @CNRS_DR20 @Bastien_Dolfi @AlexGallerand Sex‐specific impact of psychosocial stress on hematopoiesis and blood leukocytes - Dolfi - European Journal of Immunology - Wiley Online Library onlinelibrary.wiley.com/doi/full/10.10…

Glad to share our new study investigating the unknown diversity of adrenal glands macrophages. I would like to thanks all my team and collaborators for this incredible work ! cell.com/cell-reports/f…

Out in Nat Comms! nature.com/articles/s4146… Great work by @AlexGallerand, @MarionAlya, Stoyan and many others. This one is very special, and I wanted to highlight all the amazing single-cell analysis done by @mfiruleva, allowing me to do more as a senior author for the first time