Pat Lally

Excited to release BoltzGen which brings SOTA folding performance to binder design! The best part of this project has been collaborating with many leading biologists who tested BoltzGen at an unprecedented scale, showing success on many novel targets and pushing its limits! 🧵..

Ask not why would you work in biology, but rather: why wouldn't you? owlposting.com/p/ask-not-why-… openai/gemini gave this essay an A- for evocative imagery. claude gave it a C- for being emotionally manipulative. both are probably right. i feel a little sick re-reading it

Last month, @PatDotPy defended his PhD dissertation! Pat’s work studied E. coli Transcription Factors at multiple resolution scales & provided novel insights into the spectrum of TF binding (more details soon)! He is now building NGS Analysis Pipeline Services for @BU_PDC!

@jankosinski Apologies if you’ve answered this already but have you tried this with a “nonspecific” sequence? Might give that a shot later myself but curious what it would find

This is the end of the world as we know it, if this is reproducible! The new era of functional modeling has begun. I took a transcription factor with an unknown structure and folded it with its recognition sequence embedded in longer DNA. AlphaFold3 accurately positioned the transcription factor.

When a fly is buzzing around the lab

Loving our new OT2 liquid handler! Looking forward to seeing what else it can do! @opentrons #Automation #NGS #HighThroughputBiology

Free online #course launched to introduce #bioinformatics and share how we use computational tools to understand disease-causing bacteria #SkillsGap @ACSCevents @FutureLearn buff.ly/2LFykgQ