Albany Med Pathology

🔬Happy Monday, Twitterverse! We at the Path dept of AMC want to help educate residents and fellow learners alike to showcase the interesting world of pathology. We will strive to present an unknown case once at least every two weeks. Can you guess the diagnoses?🤔 #pathtwitter

CD138 is correct! The population of plasma cells showed increased ratio of kappa to lambda cells.

Case #14: for the hemepath-driven folks. This is a bone marrow biopsy. Based on what you see on the H&E, can you guess what the stain is? 🤔🔬 #hemepath #pathology #pathtwitter #medtwitter

Stain is beta-catenin.

Answer: fibromatosis / desmoid tumor

Case #13: chest mass in a patient with history of breast carcinoma. What is the diagnosis? *Hint: the stain is a nuclear stain. 🔬🤔

@isar4801 Positive 😉

@PathAlbanyMed B catenin

@rehdam S100 negative.

@PathAlbanyMed S100

@nucleololailo @kriyer68 ERG is negative!

@PathAlbanyMed @kriyer68 ERG

@MuhamadMustaf1 CD34 is negative.

@PathAlbanyMed Myofibrolastoma Versus Solitary fibrous tumor. stain is P63

Answer: micropapillary urothelial carcinoma 👏🏼👏🏼

Case #12: bladder tumor resection specimen. What is the diagnosis? 🤔🔬 #unknowns #PathTwitter #pathology #GUpath

VZV (varicella zoster stain) was positive in this case!! 👏🏼👏🏼

Case #11: hmmmMMM. I wonder what this skin biopsy from the upper back showed? Clinical DDx included bullous pemphigoid and allergic contact dermatitis. 🤔🔬#pathology #unknowns #PathTwitter #MedTwitter #dermpath

This is classical Hodgkin lymphoma, and the four stains are: PAX5 (A), CD30 (B), CD15 (C), and EBER-ISH (D).

Case #10: Classic case of a “classical” case 😉. What’s the diagnosis, and what are the four stains? (A, B, C, D) #unknowns #hemepath #pathology Case courtesy of @XiaoyanHuangMD1

Thank you @HwajeongL for this great case! This was a case of granulomatous appendicitis due to delayed appendectomy. Definitely need to exclude bugs in this case, which was done. No bugs seen 🐛👍🏼

Case #9: appendectomy specimen. Diagnosis? 🤔🔬 #pathology #unknowns #medtwitter #PathTwitter #GIpath

This is merkel cell carcinoma! CK20 showed nice perinuclear dot-like pattern of staining in the lesional cells.

Case #8: BCC, next case? What do you think? 🤔 #itsatrap #unknowns #pathtwitter #Dermpath #pathology

Good morning everyone! This is called “granular (Paneth-like) change in the epididymal epithelium! Rare and benign! 👏🏼

Case #7: Benign finding in the epididymus. What is this finding called? 🤔🔬 #beautyinthebenign #pathology #unknowns #MedTwitter