James ODonnell

Mild isolated functional VWF defects in the 30 to 50 IU/dL range are common and are associated with significant bleeding in some patients. ow.ly/PlcA50Wrynz #thrombosisandhemostasis #clinicaltrialsandobservations

New RCSI research has identified a previously unrecognised subgroup of patients with the bleeding disorder von Willebrand disease. The findings challenge current diagnostic practices and highlight a need to adapt clinical guidelines. ➡️ rcsi.com/dublin/news-an… #RCSIdiscover

Celebrating the great news of promotion to Professor of nursing for our colleague @dodonnell22 @ulsterunisonp Congratulations Professor O’Donnell!! We are #proudofuu #ulsternurse #ulsterparamedics

Delighted to be promoted to Professor of Nursing. Thanks to everyone who has supported me and believed in me.

Montgomery Educational Symposium on Hemostasis (MESH) was a huge success thanks to the incredibly bright minds and warm hearts that gathered to honor ‘Montgomery, Milwaukee’s’ amazing career @VersitiResearch

President of Haematology Association of Ireland @Paulv8205 giving an overview of 25 years of the #HAI and recognition of Liam O’Connell - Ireland’s first haematologist. @stjamesdublin @tcddublin @CancerInstIRE

BT200 interaction with the VWF-A1 domain in proximity to this lysine cluster significantly attenuates macrophage LRP1-mediated clearance. ow.ly/qa6A50Twvon #thrombosisandhemostasis

Very excited to share our science and kick off new collaborations. Coffee is also mentioned, which is excellent.

REMINDER: Our next #PBSResearch seminar series supported by @thermofisher is tomorrow Tues. 1st Oct. at 3pm in the Cheyne LT. We are thrilled to welcome Prof. James Luyendyk (@TFFVIIa) from @michiganstateu to see his fascinating work ‘targeting vWF to accelerate liver repair’🔬

#BT200 prolongs VWF half-life by attenuating macrophage-mediated clearance and specifically the interaction of K1405-K1408 in the VWF-A1 domain with macrophage LRP1. A anovel therapeutic approach for #von Willebrand disease and #hemophilia. ashpublications.org/blood/article/…

Valuable information on the mode of action of BT200 published in @BloodAdvances. It blocks VWF clearance through LRP1. BT200 is a treatment being developed for non-type 3 von Willebrand disease. tinyurl.com/mss46ja3 #VWD #VWF #Willebrand

👀Let’s take a peek at the story that made our #october #coverart In #vWD type vicenza, #vWF clearance is accelerated. How⁉️ 🧬 Atiq et al. showed that the VWF-R1205H mutation leads to loss of positive charge and increased binding to macrophage clearance receptors via LRP1 and SR-AI. A significant novel insight into the mechanism of this complex disease. ✍️@DavidLillicrap @Jme_os @ProfJSODonnell jthjournal.org/article/S1538-…

▶ Advanced analysis of platelet metabolism and mitochondrial function Sonia Águila, @Sonia_AguilaM, Centro Regional de Hemodonación, IMIB-Pascual Parrilla, UCAM, Murcia (Spain) ▶ How is NO metabolism regulating platelet function Paolo Gresele, University of Perugia (Italy) ▶ Platelet heterogeneity in health and disease Paul C. Armstrong, Queen Mary University of London Centre for Immunobiology, Blizard Institute (United Kingdom) @isth #SETH #PlateletResearch #plaquetas #platelet #Murcia

Novel functions for von Willebrand factor ow.ly/rvCi50Tr8cP #thrombosisandhemostasis #vascularbiology

Dr Alain Chan Kwo Chion @RCSIPharmBioMol features in the @siliconrepublic list of researchers to follow 🔬 Based at @IrishCtrVascBio his research focuses on approaches to treat the common bleeding disorder von Willebrand disease. More ➡️ siliconrepublic.com/innovation/7-e… #RCSIdiscover

The gene encoding von Willebrand factor is located on the short arm of chromosome 12, and a highly homologous pseudogene that does not generate functional transcripts has been mapped on chromosome 22. #VWD go.nature.com/4cSDuCA

Prof. Hervig will be sorely missed by all in the IBTS. We wish him a very happy retirement!

von Willebrand factor synthesis occurs in endothelial cells and megakaryocytes as a single-chain polypeptide that, subsequently, undergoes extensive processing. #VWD go.nature.com/4cSDuCA

Our NEW Primer on von Willebrand disease is live today! By @OmidSeidi, Eikenboom, @cecile_denis, @VeronicaFlood18, @james_paulad, @LentingPeter, Baronciani, @ProfJSODonnell, @DavidLillicrap & @flora_peyvandi #Hematology #VWD Check it out here: go.nature.com/3WyE82i

VWF-R1205H (Vicenza), known for causing enhanced clearance of VWF, ▶️causes conformational changes in the VWF-D’D3 domains & enhances VWF binding to clearance receptors LRP1 and SR-A1. @ProfJSODonnell @IrishCtrVascBio @RCSI_Irl @DavidLillicrap @Jme_os sciencedirect.com/science/articl…