Sassetti Lab

Sassetti Lab 2024

@GHatfull Bravo to Graham and the team. Important work!

Phage Therapy of Mycobacterium Infections: Compassionate-use of Phages in Twenty Patients with Drug-Resistant Mycobacterial Disease academic.oup.com/cid/advance-ar…

Happy to share the latest from Mike Kiritsy's thesis work - a comparative CRISPR screen identifies a new link between metabolism in immunity, and begins to differentiate the diverse effects of IFNg: elifesciences.org/articles/65109

Our lab has specific opening for a #postdoc interested in studying the regulation of cell growth and division in M. tuberculosis - part of a large program that fosters access to resources throughout the TB research community. Oh, and we just happen to be awesome! #postdocjobs

This small study suggests an important link between antibiotic exposure, carbon metabolism, and culturability. Larger studies are underway to understand the mechanism and clinical importance of these findings ncbi.nlm.nih.gov/pmc/articles/P…

A great example of our lab's obsession - how immunity shapes Mtb physiology and drug efficacy. Made possible by collaboration with old friends! journals.plos.org/plospathogens/…

Another great collaboration with Tom Ioerger and Colleagues at TAMU cell.com/current-biolog…

Another interesting one from the @SassettiLab! Read more for some cool insights into host immunity, pathogen respiration, and low pH! Some great work by @EJaecklein!!! biorxiv.org/content/10.110…

Thrilled to share our @SassettiLab research investigating how Mycobacterium tuberculosis survives during antibiotic treatment published in @mSystemsJ! msystems.asm.org/content/5/4/e0…

A tremendous effort from Rustin Lovewell et al. reveals the role of granulocytes in tuberculosis: nature.com/articles/s4138…

Congrats to Michelle, Adi, and the rest of the GSBS 2020 grads!!

Congratulations Dr. Bellerose! Thanks to all of our friends and colleagues that joined the Zoom defense.

Congrats to Dr. Bandekar! And thanks to the 143 colleagues that joined his virtual defense. We love this community!

Someone with active TB may infect as many as 15 people in a year, according to the WHO econ.st/2qS2urQ

Complementary work from Sassetti and Alland labs suggests that high-frequency genetic variation limits TB drug efficacy: mbio.asm.org/content/10/4/e… and biorxiv.org/content/10.110…

What an almost perfect NRSA score looks like. Congrats to Lisa!

Congrats to Eleni for crushing her QE. Now the fun starts!

Postdoctoral Opportunity in Systems Genetics of Infectious Disease - @Sassettilab. Christopher.sassetti@umassmed.edu - umassmed.edu/sassettilab/

A great collaboration with the Sacchettini lab: sacclab.com. ncbi.nlm.nih.gov/pubmed/30318462

Congrats to Kenan et al!! Also, thanks to @GHatfull whose dissection of phage recombination systems made ORBIT possible.