#MetaboliteRepair enzymes have evolved to eliminate often toxic non-canonical metabolites. Out today in @nchembio, we found that CLYBL repairs malyl-CoA, a TCA cycle side-product, to avert vitamin B12 depletion doi.org/10.1038/s41589…
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Corey Griffith
255 posts
Corey Griffith
@coreymgriffith
Metabolic Biochemist. Interested in problems that intersect analytical chemistry, metabolism, toxicology, and the environment. 🇺🇸 in 🇱🇺
Esch-sur-Alzette, Luxembourg Se unió Aralık 2016
535 Siguiendo223 Seguidores
Happy to share this preprint of my postdoc work on discovering that CLYBL repairs malyl-CoA to avert methylmalonyl-CoA mutase inhibition and loss of vitamin B12! Thanks to the team for all your help! #MetaboliteRepair
biorxiv.org/content/10.110…
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Looking forward to this afternoon's session on "Enzymatic control of problematic intermediates" at #DiscoverBMB! Three metabolite repair talks in a session - this may be a record!
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Corey Griffith retuiteado
(Nature MS) A spectroscopic test suggests that fragment ion structure annotations in MS/MS libraries are frequently incorrect dlvr.it/T2lZ8j (RSS) #nature #MassSpecRSS
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Corey Griffith retuiteado
The TCA cycle is fraught with metabolite damage. Here we describe a universal repair enzyme that prevents the TCA cycle from poisoning itself:
link.springer.com/10.1038/s41467…
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Corey Griffith retuiteado
Zebrafish model for CLN3 Batten disease recapitulates the human metabolic signatures of BMP depletion and accumulation of glycerophosphodiesters and cholesteryl esters at larval stages life-science-alliance.org/content/7/3/e2…
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Corey Griffith retuiteado
biorxiv.org/content/10.110…
Nice follow up by @mdtauqeer on his earlier work on enzyme inhibition doi.org/10.1038/ncomms…, now showing how frequent metabolic enzyme activators let metabolic pathways talk to each other
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So very proud of my friend and colleague, Lorenzo! Congratulations! 🥳
Emma Schymanski@ESchymanski
Congratulations to Dr. Lorenzo Favilli - second ECI and ECHIDNA PhD graduate. We are all so proud of you! #proudPI #metabolomics #TeamMassSpec @lcsb_uni_lu @uni_lu @FnrLux @ResearchLux Here with Carole Linster and @coreymgriffith Many thanks to our Jury & audience as well!
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Corey Griffith retuiteado
What a great team!
#environmental #cheminformatics @lcsb_uni_lu
@EmmaPalm4 @DagnyAurich Federica Vero @HibaMohamedTaha @AnjuAnjuraj15 @Begotalavera9 Camilla @PChirsir Lorenzo @coreymgriffith (out of pic @GianfrancoFrig1 )
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@ErinBakerIMS That's absolutely devastating... I am so sorry that you all had to go through that and I am glad to hear that you all are physically safe. Be mindful and don't hesitate getting help to process this... I wish you all the best! If you need something, please let us know!
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Sometimes there are no words😢 My group is physically okay but the active shooter was in our building yesterday so we hid for multiple hours until evacuated by the amazing police! Our hearts are broken for the lost faculty member! #UNC students, please let me know if I can help💔
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Corey Griffith retuiteado
Interested in rare diseases, mitochondria, non-target mass spectrometry #TeamMassSpec #cheminformatics and identification?
Exciting #postdocposition in GENOMIT consortium with rare disease cohort at @lcsb_uni_lu @uni_lu in the Linster & Schymanski groups!
emea3.mrted.ly/3fyae
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Corey Griffith retuiteado
Come join us!
We are looking for a Postdoctoral Researcher in Mass Spectrometry Workflows for Unknown Chemicals to join the Environmental Cheminformatics group at @lcsb_uni_lu @uni_lu
#TeamMassSpec #cheminformatics #OpenScience
Interested? Apply here⬇️
emea3.mrted.ly/3h2lg
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Corey Griffith retuiteado
High-throughput Saccharomyces cerevisiae cultivation method for credentialing-based untargeted #metabolomics
by Lorenzo Favilli et al @lcsb_uni_lu @uni_lu @ESchymanski @coreymgriffith #yeast #chromatography #labelling #spectrometry
#OpenAccess
link.springer.com/article/10.100…
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I see @coreymgriffith flying the @lcsb_uni_lu @uni_lu flag (not literally) right under the logo that looks like @microh_dtu from afar!
laura martinelli@martinelli7512
A real @fonia_sin led by our coordinator @PabloINik ! In front of the Opera House in the eternal city, in the occasion of our final meeting, but is it so? I doubt it 😎 we will continue playing 🙌🏻
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Corey Griffith retuiteado
A real @fonia_sin led by our coordinator @PabloINik ! In front of the Opera House in the eternal city, in the occasion of our final meeting, but is it so? I doubt it 😎 we will continue playing 🙌🏻
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Corey Griffith retuiteado
Come be a split EM/ECI postdoc like me! This is a very cool project for those interested in unknown identification.
Emma Schymanski@ESchymanski
If you are interested in a PostDoc for targeted and untargeted #metabolomics #TeamMassSpec for mitochondrial disorders working with these two groups at @lcsb_uni_lu @uni_lu funded by @FnrLux as part of the GENOMIT consortium, please apply here: emea3.mrted.ly/3dsa5
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Corey Griffith retuiteado
Thank you very much @ESchymanski @coreymgriffith Lorenzo and Carole for submitting your work to ABC!
@GNPS_UCSD @lcsb_uni_lu @uni_lu @FnrLux #metabolomics
Emma Schymanski@ESchymanski
Super #proudPI tonight to see Lorenzo's work with Carole Linster and @coreymgriffith now published - high throughput stable labeling approach for untargeted metabolomics in yeast, all data in @GNPS_UCSD and more! @lcsb_uni_lu @uni_lu @FnrLux #OpenScience link.springer.com/article/10.100…
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Many congrats to Lorenzo and the entire team! Credentialing is a powerful yet unexploited branch of metabolomics and herein, we devised a nice approach to help tackle these projects in yeast.
Emma Schymanski@ESchymanski
Super #proudPI tonight to see Lorenzo's work with Carole Linster and @coreymgriffith now published - high throughput stable labeling approach for untargeted metabolomics in yeast, all data in @GNPS_UCSD and more! @lcsb_uni_lu @uni_lu @FnrLux #OpenScience link.springer.com/article/10.100…
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