James Zwierzynski (@jameszsci) - Perfil de Twitter

James Zwierzynski@jameszsci·2h

@PamR33 Thank you Pam!!! 🤗❤️

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Dr. Pam R@PamR33·8h

Outstanding work from an outstanding grad student @jameszsci

James Zwierzynski@jameszsci

Excited to share our preprint, reviving @kristyredhorse's interest in the placenta from her PhD ~20 years ago! We find using 3D imaging that the mouse placenta is far more invasive than previously thought. Furthermore, we find a surprise from our favorite chemokine CXCL12...🧵:

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James Zwierzynski retuiteado

Mira Moufarrej@sciencemira·2d

If this work is interesting to you, we're hiring for a Senior Scientist with post-doctoral experience and a background in RNA molecular biology or whole organ imaging and analysis to join our small, collaborative team! Apply here: careersearch.stanford.edu/jobs/basic-lif…

James Zwierzynski@jameszsci

Excited to share our preprint, reviving @kristyredhorse's interest in the placenta from her PhD ~20 years ago! We find using 3D imaging that the mouse placenta is far more invasive than previously thought. Furthermore, we find a surprise from our favorite chemokine CXCL12...🧵:

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James Zwierzynski@jameszsci·4d

@EuphrosMD Thank you! It certainly plays an interesting role here - Günter Wagner's group has beautiful work that implicates Cxcl12 in the evolution of an invasive pregnancy that interests us for future work!: nature.com/articles/s4155…

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Fourth Grace@EuphrosMD·5d

@jameszsci Cxcl12 is the architect of placental geography. Without it, invasion loses its compass. That PAS parallel suggests an ancient boundary mechanism. Beautiful work.

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James Zwierzynski@jameszsci·5d

Excited to share our preprint, reviving @kristyredhorse's interest in the placenta from her PhD ~20 years ago! We find using 3D imaging that the mouse placenta is far more invasive than previously thought. Furthermore, we find a surprise from our favorite chemokine CXCL12...🧵:

biorxiv_devbio@biorxiv_devbio

3D imaging of the pregnant uterus reveals an extensively invasive mouse placenta requiring CXCL12-CXCR4 signaling biorxiv.org/content/10.648… #biorxiv_devbio

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James Zwierzynski@jameszsci·5d

This work was a product of intense work by the three of us, and we are very excited to share it with everyone! Of course, a huge thank you goes out to our funding sources, and especially everyone who has given us feedback, advice, and comments along the way.

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James Zwierzynski@jameszsci·5d

We were surprised by CXCR4-activated decidual cells in these mice, given the paucity of analysis of this receptor in these cells. However, beautiful work out this week in Nature shows a population of CXCR4+ decidual cells associated with blood vessels and pregnancy complications.