Michael Mints

Experimentalist, computational biologist or jack-of-all trades looking for a great postdoc opportunity in Sweden? I can really recommend @SchlisioSusanne at @karolinskainst , where you can study intra-tumour heterogeneity in neuroblastoma ki.varbi.com/se/what:job/jo…

@Asfyxi @avoforever Ta en tur förbi Hervey Bay om du har tid, kan simma med valar och dyka där!

@avoforever Gold coast

Badat hela förmiddagen. Bra vågor såg ut som shrek när jag försökte surfa men aja…

We’re excited to share our preprint on spatial organization in glioblastoma: doi.org/10.1101/2023.0…. We combine spatial transcriptomics (Visium) and proteomics (CODEX) to reveal a five-layer organization of cellular states and highlight a role of hypoxia as tissue organizer. 1/

1. Excited to share our new paper in @Nature! With over 1000 tumors analyzed by scRNA-seq, we provide a systematic pan-cancer characterization of transcriptional intra-tumor heterogeneity (ITH) nature.com/articles/s4158…

@Asfyxi Jamen dåså, kör hårt!

@micmints Nej nej detta är en bra tidskrift. Tack för omtanken broder

#Forskartwitter jag har blivit erbjuden att vara reviewer för en artikel submittad till en tidskrift med IF 4.8, jag är väldigt oerfaren när det gäller forskning. HJÄLP är det ens en bra idé att jag tackar ja till detta?

So that figure had a transparent background.. new version here

Cell line studies showed that HPVon cells are preferentially killed by chemo/radiation, while HPVoff cells are resistant due to their non-proliferative state. We also showed that HPV DNA copy numbers are not affected, suggesting epigenetic regulation. 6/8

Happy to share our latest work (nature.com/articles/s4158…), published in @NatureGenet, where we show that HPV is repressed in a subset of cancer cells in HPV-driven oropharyngeal cancer, making them more resistant to chemo/radiation treatment! 1/8

@TalalZarif1 @NatureGenet Thanks! No, the patient numbers are too small to do proper group (rather than intra-tumour) comparisons, but we are working on a larger bulk cohort where this is a very relevant question!

@micmints @NatureGenet Cool work!! Thank you for sharing. Was TMB examined across subgroups? It would be very interesting to examine the effectiveness of ICIs in the future based on this classification!

And thanks for previous support from @sls_sv ,@karolinskainst ,@umeauniversity !

Here's a link to the full text: rdcu.be/c83tP #SingleCell #Headandneck #CancerResearch #HPV #Genomics