Bio.Science ∴

its so stupid that pharmacology is behind such a big firewall honestly like doctor i want to sleep better can i get lemborexant? "no you have to score this number on my test first!" like i jus want better sleep doc

5-HT (Serotonin) undeniably plays massive role in neuroplasticity and the promotion of creating new connections and breaking down old ones, especially regarding selective 5-HT2A agonists (MDT, LSD, Psilocybin) which can be tremendously beneficial when it comes to breaking down repetitive maladaptive coping behaviors (PTSD, OCD etc.) but take into account that what you're breaking down is not just maladaptive coping habits, but also your very own self-identity, we are meant to have loose screws, everyone that has ever created something meaningful in this world was fucked in the head. Stagnation much often doesn't require you to take a different approach/route, but rather to double down on your efforts and being stubborn enough to persist/continue The most probable reason as to why Serotonin gets released into the PFC from the Dorse Raphe Nucleus after organisms have given up in learned helplessness models is because Serotonin largely acts as a numbing agent, making you forget about your past self/past goals and allows you to form new goals and a new identity that doesn't need achievement of a particular goal you previously failed to achieve and thus inachievement of that goal also doesn't cause you psychological pain/stress. Take into account that the 5-HT2A receptor is the most implicated Serotonin receptor when it comes to neuroplasticity in the PFC regions, what are its main endogenous promoters? DMT (Dimethyltryptamine), which is produced by the body when it's under extreme hypoxic stress (near-death experiences for example) Serotonin, which rises when you 'give up', when animals hibernate, and on a high-Tryptophan diet (linked to accelerated aging) Doesn't seem like a good thing

have you ever wondered why you even consider thinks beautiful? Albeit us humans love to think of beauty & aesthetics as something divine, something that lies beyond shallow materialism - a lot of it is actually probability densities, integrals, geometry etc... furthermore, how we think of beauty reveals how natural systems themselves are built out of inferential geometry evolutionary coupled to energetic constraint it starts making more sense when you consider the fact that your visual cortex did not evolve to passively admire reality it evolved to minimize variational free energy and encode environmental regularities while importantly, utilizing the least amount of energy to do so you can imagine your brain here basically as a bayesian inference computer that constantly updates its internal model of the world to minimize the "surprise" of sensory input, because fundamentally your brain remains a prediction machine, trying to construct a accurate reality that also accurately predicts any future event - be it the sable tooth tiger using his left or right paw or where the tree leave falls on the ground - you're constantly predicting, correcting erroneous prior predictions and based on that updating your constructed reality Natural environments that follow optimal spatial information structures ( a prominent example being scale invariant f(x) = 1/f stats..) the brain rewards this low friction, high value processing with a valence tag that your consciousness, the "you", interprets as aesthetic pleasure/considers it beautiful. beauty is pretty much rooted in structured complexity that the brain natively craves because it is highly compressible and hence perfect to navigate, analyze and survive in what makes this even more stunning is that when artificial systems are trained solely to represent natural images with maximum efficiency, they spontaneously end up using the same algorithms and field structures utilized by our human visual cortex

nothing to see here besides just absolutely ANNAHILATING any damage that my brain had to withstand from a viral infection by blasting some pig brain sludge, snorting insulin and ingesting soviet chemicals