HojaDeParra
56.9K posts







12 patients with metastatic cancer. Melanoma, breast, kidney. Doctors injected a re-engineered antibody (CD40 agonist) into a single tumor. Not IV. Not systemic. One local shot. The result: tumors shrank across the entire body, including at sites that were never touched. 2 of 12 patients hit complete remission. The injected tumors didn’t just shrink. They were replaced by organized immune tissue, tertiary lymphoid structures, essentially training camps for cancer-killing T cells. Zero severe side effects. The concept: instead of flooding the body with immunotherapy and hoping it finds the cancer, turn one tumor into a vaccine against itself. Train the immune system locally. Let it hunt globally. Nearly 200 patients now in expanded trials across bladder, prostate, and brain cancers. Published in @Cancer_Cell by Jeffrey Ravetch’s lab at @RockefellerUniv and @MSKCancerCenter























