Hunter Shain

Proud to share our new paper in Science Advances. We show that indoor tanning causes widespread mutational damage across the skin to increase melanoma risk, especially in body sites that rarely see sunlight. science.org/doi/10.1126/sc… #Melanoma #SkinCancer #CancerResearch

On the eve of the NCAA tournament, the best men's basketball programs in the Bay Area are St. Mary's and Santa Clara (not Stanford or Cal). And this is not an outlier year.

We are very pleased to share exciting news about a significant national recognition for our dept. The U.S. Department of Defense has selected Dr. David Fisher to serve as the National Director of the DoD National Melanoma Academy for the next four‑year term! Congrats Dr. Fisher✨

Same for me. Every time I submit a review, and I use an em dash through my own volition, I am worried the authors are going to think I used AI to review their paper

I've used em-dashes my whole life — they add rhythm and grace to writing. But now they're an AI tell. Can we get a grandfather clause for those of us who were fluent in em-dashes before ChatGPT launched in November 2022?

@ALionEye Did not realize Loyola was 10 in Kenpom back in 2021. Why were they an 8 seed?

Again, these same criticisms were levied against Lou Henson and, yes, Bill Self when he was here. It's a function of the fans of 30 programs screaming "Elite 8 or this season was a bust!" Every year, 22 of them can claim "this coach always comes up short" because math can be so elusive. That disconnect is what allows you to say "have appeared so wildly outmatched against all but the worst few opponents". So let's stick with the numbers. Using KenPom ratings for the opponents... 2020: Tournament canceled 2021: Beat #158 Drexel, lost to #10 Loyola 2022: Beat #67 Chattanooga, lost to #2 Houston 2023: Lost to #22 Arkansas 2024: Beat #116 Morehead State, beat #88 Duquesne, beat #8 Iowa State, lost to #1 UConn 2025: Beat #43 Xavier, lost to #16 Kentucky The only game where Illinois was favored and lost: Loyola. The only game where Illinois was an underdog and won: Iowa State. And the five losses were to KenPom #1, #2, #10, #16, and #22. Also noteworthy: after beating Illinois, 8-seed Arkansas and 5-seed Houston both knocked off a 1-seed in the next round. So yes, this is pretty much how the NCAA Tournament feels for fans of teams with those rankings at the end of the regular season (2026 expectations for the #9 team pending). One horrific loss to an 8-seed (Loyola), one solid upset of a 2-seed (Iowa State), and everything else mostly chalk.

@David_J_Adams This is interesting! Need to give it a deeper read, but the first thing I notice is that nearly every cancer subtype has fewer than 1 mutation/Mb. How do cats get 4-5 driver mutation in 11 years when it takes humans ~70 years? Or do they not need as many "hits"?

Paper from the lab science.org/doi/10.1126/sc… If you are a rich "cat lady" and want to support our research please DM me - but seriously - it was a fun project.

@EnedaToska congrats!

Thrilled to share our new work on epigenetic control of cell states by KMT2D in castration-resistant prostate cancer. Grateful to the first authors and all our great collaborators below! aacrjournals.org/cancerres/arti…

@mukundiyngr Accomplished individuals for sure, but you need to look at more award codes to get a complete picture. The bigger name scientists often go for R35, P01, and U-awards, which can pay 3x an R01.

Ever wondered who the real rockstars of R01s from the past 5 years? We ranked the most funded PIs in cancer R01s from 2020–2024. Anyone with persistent effort can (maybe) win one R01. Winning 38–48 of them over 5 years is something else entirely. R01s flow towards people whose ideas repeatedly translate into durable programs. Durability means: • hypotheses that age well • biology that generalizes • institutions that trust you with long arcs • and ideas NIH is willing to underwrite repeatedly ======== Meet the rockstars, their institutions, and an examplary funded research: Allen Gao (University of California, Davis @ucdavis) 48 R01 awards | $14.6M Sample Award: 5R01CA271327 Novel therapeutics dual targeting intracrine androgen synthesis and AR for advanced prostate cancer Xiaoqi Liu (University of Kentucky @universityofky ) 46 R01 awards | $20.3M Sample Award: 5R01CA272483-03 Targeting the PLK1/PDCD4/mTORC2 signaling to treat castration-resistant prostate cancer Tim Rebbeck (Dana-Farber Cancer Institute @DanaFarber) 43 R01 awards | $10.4M Sample Award: 5R01CA259200 Genetic and genomic variation in prostate cancer Shoujiang Gao (University of Pittsburgh School of Medicine @PittTweet) 42 R01 awards | $21.3M Sample Award: 5R01CA284554 Impact of microbiota on AIDS-Kaposi’s sarcoma development and therapy James Basilion (Case Western Reserve University School of Medicine @cwru) 39 R01 awards | $18.2M Sample Award: 5R01CA255925 Highly selective targeted theranostics for prostate cancers Binghui Shen (City of Hope Beckman Research Institute @cityofhope) 39 R01 awards | $16.6M Sample Award: 5R01CA233664 DNA repair gene mutations and prostate cancer Daniela Bota (UC Irvine @UCIMedSchool) 39 R01 awards | $10.4M Sample Award: 5R01CA263806 Targeting p38/JNK MAPK to ameliorate cisplatin-induced adverse sequelae on the nervous system Nan Hao (UC San Diego @UCSDMedSchool) 38 R01 awards | $17.1M Sample Award: 1R01AG086348 Engineered genetic clocks for control of cellular aging Zhenghe Wang (Case Western Reserve University School of Medicine @cwru) 38 R01 awards | $16.8M Sample Award: 4R01CA260629 Role of PTPRT in colon cancer progression and metastasis Tony Faber (Virginia Commonwealth University School of Medicine) 38 R01 awards | $16.6M Sample Award: 5R01CA276207 MYCN drives a ferroptotic vulnerability in neuroblastoma

And they recently issued a notice extending the period in which the old version can be used. grants.nih.gov/grants/guide/n…

Is the NIH welching on the new biosketch format? They still use a template from 2021 as an example biosketch. grants.nih.gov/grants-process…

Imploring all Warriors fans to read the actual JK article. Don't do the thing where you only read snippets posted by aggregator pages for engagement. @anthonyVslater did an awesome job, and it's absolutely worth your time.

@JohnStreicher1 @HenryYin19 Ha, I have done this before, too. I took historical grants (of mine) to see how they scored and compared them to the actual scores. There was some correlation, but in general, AI was too kind. I think it takes bold claims at face value whereas humans are suspicious

@HenryYin19 I fed my grant into ChatGPT and it scored me at a 3. I’ll take it!

Tbh I would prefer AI peer review. I don’t expect AI review to be very good, but at least I know for sure AI will read the paper, unlike some humans who can’t or won’t read.

Grants should have page limits on letters of support. If you need more than 3 pages (1 page per letter x 3 letters), then maybe you should not be leading the grant.

“ok so this is embarrassing but just for the record and just so we have it, your C.V says "Nature Scientific Reports"? sorry to have to even ask”

@BenMazer Did they read the article? Or just the title?

Read more ⬇️

Recent review from HTAN. @IamLinghua with a timely review on spatial omic technologies Cancer Cell. cell.com/cancer-cell/fu…

A new perspective is out by Kai Tan and Lichun Ma from the Human Tumor Atlas Network discussing the emerging concept of the cellular neighborhood. nature.com/articles/s4301…

How STABLE is chromosomal INSTABILITY? We followed copy numbers over years in colorectal cancer patients. Chromosomal instability is high at single cell level, but does not manifest macroscopically, suggesting negative selection of karyotypes: doi.org/10.1158/2159-8…