The Ott Lab

Interested in learning more about our lab? We have a shiny, new, up-to-date website where you can see everything that we're currently working on. Check it out! ottlab.gladstone.org

From chronic treatment to true cure: Melanie Ott (@TheOttLab) makes the case that controlling HIV isn’t the finish line—it’s just the beginning. Read more: bit.ly/4rWC8hx

Once a godsend, antiretroviral therapy is not what we should settle on. The time has come to finally cure HIV/AIDS. Read more in this commentary from Melanie Ott (@TheOttLab) bit.ly/4rWC8hx

Excited about a future in STEM? Applications are open for Gladstone’s 2026 PUMAS Summer Internship Program! PUMAS is a unique opportunity for community college students to gain real-world experience in biomedical research. Learn more on our website ➡️ bit.ly/2UVIaST

Tune in for our event on TikTok LIVE: “HIV Cure Lab Tour + Q&A"! 📆 Monday, December 1, 2025 at 10am PT 📍 Live on TikTok via @RaifDerrazi 🔗 Register: tiktok.com/live/event/757…

🚨 PUBLICATION🚨 "HIV-Induced T Cell Quiescence and the Origins of Viral Latency" in @NatImmunol From the @TheOttLab nature.com/articles/s4159…

Virologists need to reclaim the gain of function debate from politicians and set up streamlined international guidelines to work on viruses with pandemic potential. Read more in this @Nature opinion piece by @TheOttLab, @Virus_Immunity, and myself: nature.com/articles/d4158…

The Gladstone Institute of Virology has taken on a new name: the Gladstone Infectious Disease Institute. Check it out here: gladstone.org/news/beyond-vi…

Check out Dr. Melanie Ott's recent opinion piece on the SF Standard: sfstandard.com/opinion/2025/0…

Congrats Fran!

Thank you for supporting the next wave of HIV researchers. Because of you, amfAR’s 2025 Mathilde Krim Fellows are advancing bold ideas that bring us closer to a cure. Hear why your support matters.

Congratulations to Julia Prigann for being awarded the 2025 CFAR Excellence in Basic/Translational Science Award! cfar.ucsf.edu/user/11703

We are delighted that we could help with this work. Check it out here: authors.elsevier.com/c/1lEffL7PXuF0y

Scientists from Gladstone and @UCSF have developed drug candidates that could prevent future coronavirus pandemics. Read more about this recent study: bit.ly/4cHKGSC @ucsfpharmacy @UCSFMedicine @ScienceAdvances @TheOttLab @KroganLab @QBI_UCSF

Scientists from Gladstone and @UCSF has developed new antiviral drug candidates that show great promise against SARS-CoV-2, the virus that causes COVID-19, and may also be effective against other coronaviruses. Read more: bit.ly/4cHKGSC

🚨 NEW PUBLICATION 🚨 "Structure-based discovery of highly bioavailable, covalent, broad-spectrum coronavirus MPro inhibitors with potent in vivo efficacy" @UCSF @ucsfpharmacy @UCSFMedicine @ScienceAdvances @TheOttLab @KroganLab @QBI_UCSF science.org/doi/10.1126/sc…

Scientists develop powerful drug candidates that could head off future coronavirus pandemics. @UCSF @ucsfpharmacy @UCSFMedicine @ScienceAdvances @TheOttLab @KroganLab @QBI_UCSF bit.ly/4cHKGSC

Why are measles cases surging? Paul Duprex @PittTweet on the origins; @TheOttLab @GladstoneInst on measles making us sick; @ajpollard1d @UniofOxford on the #MMR #vaccine and herd immunity; and Sander van der Linden @Cambridge_Uni on misinformation. thenakedscientists.com/podcasts/naked…

Thank you to everyone who attended the HIV Mini-Symposium on March 13th! Our next Mini-Symposium will be September 23, 2025 titled 'Viral Landscapes: How to Comprehensively Monitor Evolutionary Trajectories'. We hope to see you there! youtube.com/watch?v=vjpeo8…

Did you know that viruses don’t just infect humans—they also target bacteria in our microbiome? These viruses, called phages, play a crucial role in shaping our health and could be the key to fighting antibiotic-resistant bacteria. @TheOttLab explains.

Melanie Ott explains why curing HIV remains a crucial scientific challenge, and how scientists at Gladstone are working to find a cure. @TheOttLab