
Guillermo
13.4K posts

Guillermo
@technobcn
Sysadmin (Linux), Developer (Java, Perl, C), Free/Libre OSS Enthusiast. INTP. || ★ I like #PixelArt, #Illustration, #Anime, #Japan, #Architecture || he/him




Hypothyroidism increases stress hormones, causing anxiety, high blood pressure, blood sugar dysregulation, and depression. Experimental hypothyroidism (people stopped taking their medication) led to: > +60% cortisol > 2x adrenaline > 2x noradrenaline > 2x aldosterone Expect: > Pounding heartbeat > Increased blood pressure > Higher blood sugar > Anxiety 2x noradrenaline can lead to: > Increased blood pressure > Blood vessel constriction > Heightened vigilance 2x aldosterone cal lead to: > Elevated blood pressure > Sodium retention in the kidneys > Water retention > Potassium loss in urine > Blood volume expansion +60% Cortisol can lead to: > Increased blood sugar > Insulin resistance > Type 2 diabetes > Obesity > Muscle loss > Depression > Low testosterone > Reduced immune response When thyroid hormone medication was continued, blood pressure dropped. “The observed sympathetic and adrenal activation in hypothyroidism, which is reversible with thyroid hormone treatment, may also contribute to the development of arterial hypertension in human hypothyroidism.” PMID: 11994331 Adrenaline, a key component of anxiety, is increased when cells do not have enough thyroid hormone T3. “...thyroid (hormone) depresses the secretion of noradrenaline and of adrenaline by blocking their production at the cellular level.” [PMID: 4766338] In hypothyroid patients on levo/T4, adding thyroid hormone T3 improves: > Anxiety > Depression > Quality of life "When comparing scores of quality of life and depression on T4 monotherapy versus T4/T3 combination therapy, significant differences were seen in 7 out of 11 scores, (including anxiety and depression) indicating a positive effect related to the combination therapy. Forty-nine percent preferred the combination and 15% T4 monotherapy." [PMID: 19666698] Histamine, another driver of anxiety, is also elevated by hypothyroidism. Experimental hypothyroidism: > 4.5x increases in mast cells > 50% increase in histamine > Increased degranulation “We found that hypothyroidism resulted in a significant increase in number of MCs and the histamine content in the skin and exorbital lacrimal gland of Wistar rats.” [PMID: 35883387]




















