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“Thyroid hormone, progesterone, and carbon dioxide all reduce inflammation while facilitating normal tissue remodeling. Fibrosis of the heart and liver… can be regressed by thyroid hormone…” — Ray Peat: Regeneration and degeneration: Types of inflammation change with aging Hypothyroidism is associated with increased fibrosis in fatty liver disease. “TSH ≥ 2.5 was significantly associated with increased risk of significant liver fibrosis (60% increased risk)...”PMID: 36685269 Lower thyroid hormone (T3) is associated with increased fibrosis in NAFLD. “The levels of Free T3, Free T4, Total T3 and Total T4 in patients with progressive liver fibrosis were significantly lower in patients with progressive liver fibrosis than that in patients without progressive liver fibrosis...” PMID: 35641932 “T3 is able to antagonize fibrotic processes in vivo. Liver fibrosis induced by carbon tetrachloride is attenuated by thyroid hormone administration to mice, whereas aged thyroid nuclear receptor knockout mice spontaneously accumulate collagen. Furthermore, skin fibrosis induced by bleomycin administration is also reduced by the thyroid hormones. These findings define an important function of the thyroid hormone receptors and suggest thyroid nuclear receptor ligands could have beneficial effects to block the progression of fibrotic diseases.” —Thyroid hormones inhibit TGF-β signaling and attenuate fibrotic responses A drug (resmetirom) that activates the thyroid hormone receptor similarly to thyroid hormone T3 improves liver fibrosis in humans. “Both the 80-mg dose and the 100-mg dose of resmetirom were superior to placebo with respect to NASH resolution and improvement in liver fibrosis by at least one stage.” NASH (nonalcoholic steatohepatitis) is a liver disease where fat buildup in the liver causes inflammation and liver cell damage, not due to alcohol use. “NASH resolution with no worsening of fibrosis was achieved in 25% of the patients in the 80-mg resmetirom group and 30% of those in the 100-mg resmetirom group, as compared with 10% of those in the placebo group. Fibrosis improvement by at least one stage with no worsening of the NAFLD activity score was achieved in 24% of the patients in the 80-mg resmetirom group and 26% of those in the 100-mg resmetirom group, as compared with 14% of those in the placebo group.” PMID: 38324483 Above range levels of thyroid hormones are also associated with liver fibrosis - it’s about getting the levels in the optimal range.

オハイオ州立大学ではこれを逆手に取り、あえて最初から舗装路を完璧に作らず、利用者が芝生の上を自由に歩くのを待ち、後からその踏み固められた跡に合わせて道を舗装した。

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