Basler Lab

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Basler Lab

Basler Lab

@Basler_Lab

Unraveling the secrets of bacterial injection needles .. (among other things)

Basel, Switzerland शामिल हुए Ağustos 2010
13 फ़ॉलोइंग1.9K फ़ॉलोवर्स
Basler Lab
Basler Lab@Basler_Lab·
Thank you, Katrin (@biozentrum) for a great summary of our paper! You can also check out this "Behind the Paper" written by @ATejadaArranz: communities.springernature.com/posts/mechanis…
Biozentrum, University of Basel@biozentrum

New research by @Basler_Lab reveals a surprising microbial trade-off: The bacterium Pseudomonas aeruginosa activates a general defense program to survive “speargun” attacks from rival bacteria, but this defense makes it more vulnerable to antibiotics. 👇biozentrum.unibas.ch/news/detail/ho…

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Basler Lab
Basler Lab@Basler_Lab·
Update to BacFighT6, with presets for easy exploration of complex behaviors: sites.google.com/view/bacfight6 Try "battle royale" preset where prey (blue) produce capsule, attackers (red) move towards prey and feed on it, defenders (orange) retaliate! Took a while to eliminate the reds!
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Basler Lab
Basler Lab@Basler_Lab·
@NatureRevMicro Thank you for all the help putting this review together! Anyone who would like to learn more about T6SS and run simple simulations of bacterial interactions, feel free to explore this: sites.google.com/view/bacfight6/
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Basler Lab
Basler Lab@Basler_Lab·
The prey (blue) multiply, don't move and produce capsule (purple). The predators (red) move towards prey and attack non-kin. They divide only if they lyse prey. The defenders (orange) move randomly and defend themselves by retaliation (divide if they lyse a cell). Who wins?
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Basler Lab
Basler Lab@Basler_Lab·
Check out the NotebookLM powered interactive Q&A: sites.google.com/view/bacfight6… This is based on the scientific literature and the simulation code. Literature is cited in the help and the documentation. Extremely helpful!
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Basler Lab
Basler Lab@Basler_Lab·
Major update to BacFighT6: sites.google.com/view/bacfight6/ Simulate the role of motility/chemotaxis, capsule production, activation by autoinducers, contact dependent killing, kin-exclusion, foraging and more. Long simulations, extensive data import/export and analysis. Interactive Q&A!
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Basler Lab
Basler Lab@Basler_Lab·
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Basler Lab
Basler Lab@Basler_Lab·
To make our research more approachable, I used #Gemini to develop (mostly by #vibecoding) a simulation of #T6SS mediated bacterial interactions. I hope that you'll have as much fun as I have with this and that you'll learn something new! sites.google.com/view/bacfight6/
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Basler Lab@Basler_Lab·
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Basler Lab
Basler Lab@Basler_Lab·
Poke bacteria with a sharp needle and they poke back in just a few seconds! Congratulations to Mitchell (and others) for this analysis of Pseudomonas #T6SS assembly in response to membrane damage! Collaboration with Rod Lim's lab @biozentrum + @SNIunibas! science.org/doi/10.1126/sc…
Basler Lab tweet media
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Basler Lab
Basler Lab@Basler_Lab·
For over 10 years, we've known that neighboring P. aeruginosa cells engage in rounds of H1-T6SS firing. It was unclear how this starts since H1-T6SS only fires in response to an attack. Now we know: journals.asm.org/doi/10.1128/mb… Congrats Max, Sharath, Alejandro, and others!
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खोजें

@biozentrum @ATejadaArranz @NCCR_AntiResist @JenalLab @NatureRevMicro @jan_wohlfarth @DannyJamesWard @Joana_MPereira