CD Genomics

CREsted: modeling genomic and synthetic cell-type-specific enhancers across tissues and species CREsted is an efficient and user-friendly toolbox for analysis, modeling and design of cell-type-specific enhancers across diverse species. nature.com/articles/s4159…

New in Nature Comms: How does PGE2 inhibit T cell activation? Using single-cell multi-omics, researchers mapped transcriptional & chromatin changes in Th17 cells, linking these epigenetic shifts to #IBD genetic associations. nature.com/articles/s4146… #Immunology #SingleCell

The mRNA sequence is just the blueprint; the epitranscriptome dictates the function. Learn how MeRIP-seq uses targeted immunoprecipitation and high-throughput sequencing to map m6A modifications across the entire transcriptome. Explore the guide: #Epitranscriptomics" target="_blank" rel="nofollow noopener">cd-genomics.com/epigenetics/re… #m6A

The mRNA sequence alone does not dictate gene expression. Our MeRIP-Seq service maps transcriptome-wide m6A modifications with high precision to reveal post-transcriptional regulatory networks. Learn more: #Epigenetics" target="_blank" rel="nofollow noopener">cd-genomics.com/merip-sequenci… #m6A

Standard bisulfite sequencing masks the difference between 5mC and 5hmC. Discover when to use WGBS, 5hmC-Seal, or oxBS-Seq to capture true regulatory dynamics in your research. Explore the guide: #Epigenetics" target="_blank" rel="nofollow noopener">cd-genomics.com/epigenetics/re… #Genomics

5hmC is a critical driver of gene expression. Accurately quantify 5mC and 5hmC across the genome with our advanced sequencing and bioinformatics platforms. Learn more: #DNAmethylation" target="_blank" rel="nofollow noopener">cd-genomics.com/5mc-5hmc-seque… #Sequencing

Missing rare cells in bulk RNA data? CD Genomics’ scRNA-seq resolves gene expression at the single-cell level, uncovering true heterogeneity for advanced research. Explore: #scRNAseq" target="_blank" rel="nofollow noopener">cd-genomics.com/single-cell-rn… #Transcriptomics

Preserve spatial context in your RNA-seq data. 🧬 CD Genomics' 10x Visium services map whole transcriptomes onto intact FFPE & fresh frozen tissues. Turnkey bioinformatics included. Explore the workflow: cd-genomics.com/10x-spatial-tr… #SpatialTranscriptomics

A new atlas in @NatureComms uses Stereo-seq to provide high-res spatial transcriptomic & proteomic maps of the human thymus. It geopositioned rare mimetic cells and the TF networks regulating them. A vital resource for immunology! Paper: nature.com/articles/s4146…

The new METALoci framework reveals massive 3D genome rewiring during sex determination. It uncovered a hidden non-coding region at the Fgf9 locus and identified Meis genes as key regulators. A major leap for 3D mapping! 🧬 Paper: nature.com/articles/s4159… #Genomics #Bioinformatics

Clinical researchers: Don't let your FFPE blocks gather dust. Our 10x Visium service unlocks deep transcriptomic data from archived samples. Map gene expression in situ to reveal new disease mechanisms in the tumor microenvironment. cd-genomics.com/10x-spatial-tr… #Oncology #FFPE

What’s the bottleneck in your microbial research? 🔬 If you need strain-level resolution ➡️ Single-cell Genomes. If you need stress response/function ➡️ scRNA-seq. CD Genomics provides the workflow to capture what bulk sequencing misses. Details: cd-genomics.com/download-info-…

Stop choosing between the genome and the methylome. 🧬 Our Illumina 5-base sequencing service detects A, T, G, C, and 5mC in a single readout. No bisulfite damage. No 90% DNA loss. Just high-fidelity multi-omics. Learn how: cd-genomics.com/illumina-5-bas… #Genomics #Epigenetics #DNA

Short-read methods often leave isoform-level translation ambiguous. Long-read RNC-seq provides end-to-end connectivity of ribosome-associated RNAs, mapping alternative splicing directly to the active translatome without assembly. RUO. #RNCseq rna.cd-genomics.com/long-read-rnc-…

Transcriptomics shows potential; Ribo-seq reveals reality. Our ultra-low input workflow supports ribosome profiling from as few as ~200 cells (CTCs/oocytes), enabling translation efficiency and P-site mapping for rare samples. RUO. #Translatomics rna.cd-genomics.com/ribo-seq-ribos…

mRNA levels only partially explain protein abundance. Translatomics shifts the focus to active translation kinetics and ribosome occupancy for a higher-resolution view of the functional proteome. For research use only. #Translatomics rna.cd-genomics.com/translatomics-…

New in @NatureGenetics: LoopID maps proteins at enhancer–promoter loops and finds JMJD2/KDM4 promotes looping independent of demethylase activity, likely via IDR/condensate mechanisms in mESCs. nature.com/articles/s4158… #Chromatin #Epigenetics

Stop choosing between DNA methylation & chromatin profiling. 🧬 New in @NatureComms: 6-base-CUT&Tag sequences 5mC/5hmC at targeted chromatin sites. H3K4me1-linked signatures distinguish enhancer states in mESCs. 🔬 nature.com/articles/s4146… #Genomics #Epigenetics

High background noise ruining your ChIP-seq? 📉 CUT&RUN bypasses cross-linking and sonication to deliver cleaner data and higher resolution for TF binding sites. If you're working with rare cells or clinical samples, it's time to switch. cd-genomics.com/resource-chip-… #CUTandRUN

m⁶A is just the beginning of the story. 🧬 Mapping the epitranscriptome requires precision. Whether you’re studying m⁶A, m⁵C, or m¹A, our sequencing services deliver high-resolution maps of RNA modifications across the transcriptome. cd-genomics.com/rna-methylatio… #RNA #Genomics