Clinical Pharmacology & Analytical Chemistry Lab

Our recent work was featured as a Clinical Research Update in HIV Specialist Magazine!! 💊 Engel N, et al. Optimizing On-Demand Tenofovir Disoproxil Fumarate/Emtricitabine Dosing in Women for HIV Prevention. J Infect Dis. 2026 Feb 18;233(2):257-260. onlinedigeditions.com/publication/?i…

We supported 7 abstracts at CROI 2026!! Nathan Engel and Amanda Poliseno had great poster presentations, and our team posed with the Blue Blear in Denver, Colorado 😀

New @JIDJournal editorial favors pursuit of a clinical trial assessing on-demand #PrEP in women following our model-informed predictions of its efficacy for #HIVprevention 🔗 Editorial: academic.oup.com/jid/advance-ar… 🔗 Original Publication: academic.oup.com/jid/advance-ar…

CPAC Lab holiday fun!!

Our research advocating for 2-1-1-1 on-demand PrEP for cisgender women was featured in @BodyPROHIV! Check out Mackenzie Cottrell's interview with commentary from Jenell Stewart @HennepinHC discussing this "exciting step in the right direction" 🔗thebodypro.com/hiv/on-demand-…

New from our lab! Adding a 4th day to the on-demand PrEP regimen may boost HIV protection for cisgender women, according to new modeling research. academic.oup.com/jid/advance-ar… #HIVPrevention #PrEP #WomensHealth #UNCPharmacy

🎉 Happy to share that Eli Rosen was awarded an R01! This collaboration with OHSU will benchmark PK for both long-acting and daily ARVs in rhesus macaques and examine how pre-treatment immunopathogenic damage affects ARV tissue penetration reporter.nih.gov/search/xxd0xcu… #HIVResearch

Our collaboration with University of Colorado compares direct vs. indirect DBS assays for HIV PrEP adherence. We offer guidance for clinical interpretation, including adjustments for sample degradation outside cold-chain. 🔗 doi.org/10.1093/jac/dk… #HIVPrevention #PrEP

Antiretrovirals don’t reach all genital tissues equally—some areas may be underprotected. New imaging from a collaboration with our laboratory reveals why this matters for prevention and cure. #HIVresearch #ARVs #HIVprevention …ncbi-nlm-nih-gov.libproxy.lib.unc.edu/40323085/

New guidelines from a collaboration with our laboratory improve how we read PrEP drug levels in blood spots—helping ensure people get the protection they need. #HIVprevention #PrEP #Adherence …ncbi-nlm-nih-gov.libproxy.lib.unc.edu/40536250/

The HIV PDR is revolutionizing how HIV drug data is shared—making decades of research searchable, standardized, and ready to power the next breakthroughs in treatment and prevention. #HIVresearch #DataSharing Check out our publication here 👉 doi-org.libproxy.lib.unc.edu/10.1002/cpt.36…

#CROI2025 was fantastic! We are incredibly proud of Mackenzie Cottrell and her well-received oral presentation, "Optimizing On-Demand Tenofovir Disoproxil Fumarate/Emtricitabine Dosing in Women for HIV Prevention", which is featured on NATAP! natap.org/2025/CROI/croi…

Check out our upcoming abstract presentation when you're at #ASCPT2025!! A Modeling Approach to Expedite the Development of a New Long-Acting Controlled-Release Multipurpose Formulation Containing Medroxyprogesterone Acetate

📊Long-Acting Injectable CAB/MPA MPT Implant for Prevention of HIV and Unintended Pregnancy

📊Dose-Ranging Pharmacokinetics and Efficacy of a 90-Day Multipurpose IVR Delivering Islatravir 📊Effect of Antiretroviral Regimen on Contraceptive Failure Among Women Using Injectable Contraception

We are authors on 8 abstracts at #CROI2025!! Titles for 3 oral 🎙️ and 5 poster 📊 presentations are below

Already looking forward to next year's International Workshop on Clinical Pharmacology of HIV, Hepatitis, and Other Antiviral Drugs! Enduring materials from this year's conference available here: academicmedicaleducation.com/meeting/intern…

Excited to announce our work was nominated for the 2024 Charles C. Shepard Science Awards @CDC! ncbi.nlm.nih.gov/pmc/articles/P…