WestermannLab

We are excited about this study as multiple studies had suggested that such an outer kinetochore receptor for Aurora B must exist. We feel it’s an important step towards understanding how Ipl1/Aurora B achieves tension-dependent substrate phosphorylation at the outer kinetochore.

Alex shows that the mutant is very sensitive to a reduction in Ipl1 activity. However, it can be rescue it by recruitment of active Ipl1 to KMN in vivo. Biochemically Ipl1-Sli15 binds reconstituted KMN via Spc105-Kre28 in vitro, the binding is counteracted by Ipl1 phosphorylation

We are excited to share our latest work in context of the colaborative research consortium 1430 @Crc1430. A preprint is available on bioRxiv (doi.org/10.1101/2024.1…).

Errors during cell division can have dire consequences. If you are interested in understanding how kinetochores and the microtubule cytoskeleton work together to allow faithful chromosome segregation in mitosis apply to @LabWestermann @IMPRS_LM. #PhDposition #celldivision #IMPRS

Spread the word! @unidue is seeking a junior #professor for #cellularbiochemistry at the Faculty of Biology @unidue_zmb. ➡️nature.com/naturecareers/… #facultyjobs #academicjobs #sciencecareers #TenureTrack

Excited to share my first first-author paper. Our work @hemmo_lab on lysosomal damage sensing and lysophagy initiation is out in @MolecularCell sciencedirect.com/science/articl…. Here we show how cells triage damaged lysosomes for lysophagy via lipid-packing defect sensing by SPG20/Spartin

Congratulations to our PhD student Sharvari for submitting her thesis. #Bub1licious

On our way to #cellbio2023. Visit us at our posters P2643, P2645 and P2670 on Tuesday 12:15-15:15. We are happy to discuss our research with you.

Welcome to our new PhD student @Sonja_Hbrkrn, who will work on the fate of inner kinetochore subunits.

Excited to share our latest preprint, excellent work by Emily and @erinejenson! Extensive mutagenesis of the Ndc80c revealed a very busy 'interaction hub,' vital for Mps1 binding and competitive regulation of localization: biorxiv.org/content/10.110…

Our work sheds new light in a mechanism how end-on attachment maturation can regulate the recruitment of Mps1 and shows the tight interconnection between error correction and the spindle assembly checkpoint.

The surface on Ndc80c that binds Mps1 also serves as interface for the Ipl1 regulated engagement of Dam1 at bi-oriented kinetochores. Dam1 competes with Mps1 in vitro and Dam1 mutants that mimic Ipl1 phosphorylation cannot displace Mps1 efficiently.

We are excited to share our latest preprint on BioRxiv (doi.org/10.1101/2023.1…). Together with @AndreaMusacchi1 we investigated the regulated recruitment of Mps1 to the budding yeast kinetochore and propose a model that puts Mps1 localization under indirect regulation of Ipl1.

Lab retreat at the zoo :) #retreat #kinetochoreandmore #fun

We have an opening for a #PhD Position. Apply now to join us @WWU Münster and work on an exciting #cryoEM project with focus on the interplay between pore forming toxins and receptors at the synaptic interface @SFB1438. RT appreciated

What a challenging but also exciting year! Three finished PhD theses, great publications and a nice Christmas party with all lab members. We wish you all Happy Holidays and a Happy New Year 🎁🎄🎊 #kinetochoreandmore #PhDone #HappyHolidays #glitter #celebration

Congrats to Alex for defending his PhD thesis 🥳🥂🎉 well done! #kinetochoreandmore #number11 #siewerdensoschnellgroß #explosion