Daniel Wrapp

Can we leverage recent developments in machine-learning & protein design to tackle previously intractable challenges? The answer is yes and we show it in this study led by the one and only @Dr_MattMcCallum @HHMINEWS @UWBiochemistry 1/9 biorxiv.org/content/10.110…

Check out our pre-print describing a CCHFV glycoprotein complex in the pre-fusion conformation! We used several engineering tricks to design our final construct, GP38-GnH-DS-Gc. Great collaborative effort, led by graduate student @Eliza4Science! biorxiv.org/cgi/content/sh…

My group at @ISTAustria is recruiting a lab manager/research technician to join when we start in July! If you're passionate about science and thrive in a dynamic environment, apply here: ista.ac.at/en/job/?title=… #ResearchJobs #LabManagement #ScienceCareers

Excited to share the pre-print describing our efforts to stabilize the HCMV gB ectodomain in a prefusion-like conformation. We and others have now routinely stabilized class I viral fusion proteins, but class III viral fusogens have been more difficult.

My Department (Biochemistry, Microbiology and Bioinformatics @ Université Laval) has 2!! tenure track positions open: one in viral ecology and one in microbial functional genomics. Awesome place to start your new lab and wonderful colleagues! 😉 Get in touch if interested. 🦠🤓

Well deserved!! Congratulations @McLellan_Lab !

@just_Thande @JVirology @TheDHVI Hope you find them to be as useful as I have!

@LabWrapp @JVirology @TheDHVI Love this paper! We will introduce these mutations into our next set of SOSIPs for sure :)

Very happy to share the peer-reviewed version of our manuscript, available now ahead of print with open access at @JVirology ! Wonderful collaborative effort with my colleagues here @TheDHVI journals.asm.org/doi/10.1128/jv…

@cesilvis @DHVI_Struc_Bio @lab_haynes @TheDHVI TriPro doesn't quite have the same ring to it :)

@LabWrapp @DHVI_Struc_Bio @lab_haynes @TheDHVI Nice stuff? What is next, hexapro? ;)

Our preprint has been released on bioRxiv! Details a new stabilization strategy that should be a useful tool for researchers trying to produce tricky HIV Env proteins. Great collaborative effort from @DHVI_Struc_Bio @lab_haynes @TheDHVI biorxiv.org/content/10.110…

@EdgarHodge7 @DHVI_Struc_Bio @lab_haynes @TheDHVI Could be! Perhaps we ought to add Ce1176 to the panel next?

@LabWrapp @DHVI_Struc_Bio @lab_haynes @TheDHVI Cool paper! I love the variation in Env. I wonder if the 2P mod has a lesser effect in JRFL and B41 trimers bc they already have a more protected/rigid dynamic phenotype in their base gp41 subunits? cell.com/iscience/fullt…

@ScottiePipetten You're gonna make me blush chum

It’s always a good day when I get a new DWrapp paper to read!

@David_RMartinez @DHVI_Struc_Bio @lab_haynes @TheDHVI Haha thanks David! History often rhymes...

@Dapeng_LI @DHVI_Struc_Bio @lab_haynes @TheDHVI Thanks Dapeng!

@LabWrapp @DHVI_Struc_Bio @lab_haynes @TheDHVI Congrats Daniel! Way to go!!

@PatByrne0 @DHVI_Struc_Bio @lab_haynes @TheDHVI Thanks Pat!

@LabWrapp @DHVI_Struc_Bio @lab_haynes @TheDHVI Congrats Daniel! Looking forward to reading it

@McLellan_Lab @DHVI_Struc_Bio @lab_haynes @TheDHVI Thanks Jason!

@LabWrapp @DHVI_Struc_Bio @lab_haynes @TheDHVI Congrats Daniel!

Delighted to have my 1st first-author paper @CellReports! High-res site Ø and V complexes. Plus, now includes structural mapping of two non-canonical sites at the trimer interface, which are preF targets but elicit low neut mAbs. Thanks to all involved! cell.com/cell-reports/f…

Come work with us! We are hiring a lab manager to support our team investigating a broad spectrum of emerging and re-emerging viruses and developing vaccines & therapeutics! Please RT and pass the word as widely as possible.

@McLellan_Lab @TheMenacheryLab @UTAustin

@LabWrapp @TheMenacheryLab @UTAustin Need some lessons from McConaughey

Just saw @McLellan_Lab on the @UTAustin commercial during the Bama Texas game.

@McLellan_Lab @TheMenacheryLab @UTAustin When are they finally going to let you ride Bevo?

@TheMenacheryLab @UTAustin Lol, my lab and my mom saw it too. Phones blowing up 😉