PagèsLab

Exciting opportunity: we are hiring a postdoctoral fellow for a fully funded 2-year position!

Amazing view from the 24th floor of the Sorbonne tower at the 7th German-French DNA Repair Meeting! Excited to give my talk tomorrow!

open access version here: hal.science/hal-05250217

New paper out! We show that RecBC remodels single-stranded DNA gaps to protect them from ExoI (sbcB) 3′-5′ exonuclease degradation during replication of damaged DNA. doi.org/10.1073/pnas.2…

#ResultatScientifique 🔎| Découvrez la dernière publication de Vincent Pagès et ses collaborateurs ⤵️ 🤝 @CNRS @CNRS_dr12 @crcm_marseille @Pages_lab 📕 @NAR_Open | buff.ly/dmZPFD3

Our key findings: -DNA polymerase η swiftly bypasses UV-induced lesions at the replication fork. -Post-replicative gaps allow Translesion Synthesis (TLS) to compete with Damage Avoidance (DA), reducing mutagenicity. -Gap extension by Exo1 nuclease favors DA and reduces TLS

Our latest article, in collaboration with Helle Ulrich, explores how the timing of lesion bypass and gap processing impacts genome stability. doi.org/10.1093/nar/gk…

How does Pol IV overcome strong replication blocks in E. coli? Our latest study with @JoeLoparo uncovers a bipartite clamp interaction that helps Pol IV compete with Pol III, enabling efficient TLS at stalled forks and reducing mutagenesis. buff.ly/3Xbgjxd

🎉 The CRCM wishes you a Happy New Year!  ✨ May this new year be rich in discoveries, collaborations and successes 🦠

Join the conversation and get your abstract in soon!

📣 Register now until March 2nd, 2025, for the next Genome Instability and Human Disease international course at @institut_curie! Gain knowledge of mechanisms ensuring genome stability, from fundamental molecular pathways up to large scale approaches. ▶️training.institut-curie.org/courses/genome…

The versatile REV7 protein plays important roles in cancer development and chemotherapy resistance. Our lab's own Lara Maggs just published a comprehensive review of REV7 biology in a Frontiers issue collated by @lab_chatterjee. Check it out here: frontiersin.org/articles/10.33….

Recruiting a postdoc to work on our yeast project

We are organizing a FREE small symposium on DNA replication and replication stress on December 2nd and 3rd in Montpellier, France. Slots are still available for posters and talks. More info here: replication.sciencesconf.org

We are pleased to inform you that the meeting “From Genome Instability to Cancer: A tribute to Angelos Constantinou” that will take place in Carry-Le-Rouet from March 10th to March 13th 2025 is now open for registration on the link: tribute2angelos.fr/page/home/

🧬#DNAreplication: the mystery unravels🧬 Looking forward to the EMBO/EMBL Symposium #EESreplication, which starts today! @EMBLEvents

🧬 Join us tomorrow for an exciting seminar by @Terence_Strick, Full Professor at @ENS_ULM! He will present on “A DNA scaffold to study the repair of double-strand breaks.” 🗓️ Tuesday, Sept 24th, 2024 🕚 11:00 AM 📍 IPC2 Amphitheater 💻 Zoom: univ-amu-fr.zoom.us/j/87002272745?… #DNArepair

New review article, written by Lewis Bainbridge @LewisBainb53268 and me. This article focuses on the diverse roles of replicative DNA polymerases during genome replication and their molecular basis. sciencedirect.com/science/articl…

My 1st @nanopore sequencing. Love the summer when I can spend some time at the bench...

I am glad to share our last work uncovering MCM/RNR interactions and their role in genome integrity journals.plos.org/plosgenetics/a…