Simon Mathis

239 posts

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Simon Mathis

Simon Mathis

@SimMat20

PhD @Cambridge_Uni | AI in protein design & engineering | biotech & environmental applications | enzymes | geometric DL | prev. @ETH_physics

London, UK शामिल हुए Nisan 2020
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Kieran Didi
Kieran Didi@DidiKieran·
📢 We’re launching Proteina-Complexa — and after the Jensen keynote mention, we definitely had to post this thread now ;) Atomistic binder design with generative pretraining + test-time compute, plus large-scale wet-lab validation. Project page: research.nvidia.com/labs/genair/pr… 🧵 1/n
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Simon Mathis
Simon Mathis@SimMat20·
Today at 11am I’ll present some of the exciting work in AI x Bio we’ve been up to at @Latent_Labs at the @RenPhilanthropy booth (Hall A/B, booth 1343 @NeurIPSConf - straight through the entrance at the back left). Come say hi!
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Simon Mathis
Simon Mathis@SimMat20·
@Latent_Labs @RenPhilanthropy @NeurIPSConf If you can't make it at this time, we're at neurips for the next couple of days - reach out to me or any of our team if you're interested catching up over coffee. There'll also be an event on Saturday: x.com/saakohl/status… Looking forward to many interesting conversations 🙌
Simon Kohl@saakohl

We've had a whopping 500+ sign-ups for our @NeurIPSConf mixer tomorrow, heavily waitlisted now! 🤩 Traveling to San Diego now and can't wait for the workshops and our mixer, electric AI fo Bio scene right now! Lots of the @Latent_Labs team are on-site already, let me know if you'd like to meet for a chat!

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Rohith Krishna
Rohith Krishna@r_krishna3·
Today, we report a method for design of active enzymes, RFdiffusion2, in @naturemethods. For the first time, we are able to design enzymes with native-range catalytic activity. We also are releasing our next frontier model, RFdiffusion3, code 👇
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Joey Bose
Joey Bose@bose_joey·
Come do a PhD with me 😀! Promise of fun science and great coffee ☕
Gilad@giladturok

I like the way @joeybos lays out his vision for PhD supervision! Seems intense and rewarding.

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Charlie Harris
Charlie Harris@charlieharris01·
🚨New package alert! 🧬 Introducing Pocketeer: A lightweight, fast protein pocket finder in pure Python! I built this as a Pythonic version of fpocket because I wanted something that could easily calculate subpockets. > pip install pocketeer Link at end of the thread 🧵(1/7)
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Adam Broerman
Adam Broerman@adam_broerman·
We sought to make proteins both potent and FAST. We used #proteindesign to design precise control over protein interaction lifetimes, enabling us to construct rapid-response circuits, biosensors, and switchable cytokines. Now published @Nature! Links to paper and tutorial below.
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Rohith Krishna
Rohith Krishna@r_krishna3·
We asked ourselves what could we do if we worked cooperatively as a team to create a single model that could design any biomolecular interactions. Yesterday, we reported details of RFdiffusion3, the next step towards building functional proteins straight from the computer.
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Jasper Butcher
Jasper Butcher@butcher_jasper·
Very excited to share our paper "De novo Design of All-atom Biomolecular Interactions with RFdiffusion3", now on BioRXiv. biorxiv.org/content/10.110… 1/n
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Kieran Didi
Kieran Didi@DidiKieran·
La-Proteina open source now, excited to see what people build with it!
NVIDIA Healthcare@NVIDIAHealth

🧬La-Proteina🧬 The first generative model demonstrating accurate co-design of fully atomistic protein structures (sequence + side-chains + backbone) at scale, up to 800 residues, with state-of-the-art atomistic motif scaffolding performance - has just made its code open-source! Learn more 🧵

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Alex Tong
Alex Tong@AlexanderTong7·
Thrilled to announce I'm starting as a Principal Investigator at #Aithyra in Vienna! We'll be developing generative models to understand cell biology and design proteins. I'm hiring PhDs, Postdocs, & Visiting Researchers! PhD applications by Sept 10: apply.cemm.at
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Jason Yang
Jason Yang@jsunn_y·
Check out our new perspective "Illuminating the universe of enzyme catalysis in the era of artificial intelligence" now out in @CellSystemsCP ! We discuss a vision and path forward for genetically encoding almost all chemistry, powered by new AI tools: authors.elsevier.com/c/1lg4h8YyDfuZ…
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Nathan C. Frey
Nathan C. Frey@nc_frey·
Where are all the de novo designed therapeutics? In a guest post by @frdreyer, we break down what the actual bottlenecks, challenges, and opportunities are in building and deploying purely in silico drug discovery engines, with a focus on antibody structure. Link below 👇
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खोजें

@chaitjo @Latent_Labs @RenPhilanthropy @NeurIPSConf @SciTechgovuk @charlieharris01 @naturemethods @Nature