
SPRK
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SPRK रीट्वीट किया

BIIB080 floods the cortex but barely reaches the hippocampus.
$ARWR ARO-MAPT goes subcutaneous through the transferrin receptor and hits the deep brain uniformly.
Same target. Better real estate.
New paper on the 2H2026 readout setup, now on Substack:
bioboyscout.substack.com/p/aro-mapt-the…
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SPRK रीट्वीट किया
SPRK रीट्वीट किया


I’d like to the NHL Player Safety for not suspending Jamie Benn.
There was a lot of attention on Benn in this series for his cheap plays, but man what a horrendous series for the #TexasHockey cap’n.
6 Games:
0 goals
0 assists
0 points
-7
#mnwild
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$ARWR trades at over $10B today.
If ARO-MAPT's Phase 1 reads positive in 2H 2026, the math says it's worth $55-$90B to a strategic acquirer.
Not a guess. Four independent methodologies. Same range.
Full paper: drive.google.com/file/d/1D5eD6Y…
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SPRK रीट्वीट किया
SPRK रीट्वीट किया

SPRK रीट्वीट किया
SPRK रीट्वीट किया
SPRK रीट्वीट किया

SPRK रीट्वीट किया
SPRK रीट्वीट किया
SPRK रीट्वीट किया
SPRK रीट्वीट किया

SPRK रीट्वीट किया
SPRK रीट्वीट किया

$IOVA
has 4 big near-term catalysts that could ignite serious upside:
Tandem Meetings 2026 Real-World Data Drop
New real-world evidence on Amtagvi in advanced melanoma (building on strong ~49% ORR commercial data).
Q4 2025 Earnings + 2026 Guidance
Expected Feb 26, 2026. With 2025 revenue guidance reaffirmed at $250-300M and >1,000 patients treated, look for accelerating sales, margin gains from in-house manufacturing, and potentially upbeat 2026 outlook to spark a rally.
Endometrial Cancer Results (IOV-END-201)
Initial data from Phase 2 in advanced endometrial cancer (post-PD-1) on track for early 2026. Huge unmet need—no approved options here—positive readout could unlock a new major indication and expand the platform massively.
IOV-4001 (PD-1 Knockout TIL) Results
Clinical results in previously treated advanced melanoma expected Q1 2026. This next-gen engineered TIL could show boosted efficacy over standard—
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SPRK रीट्वीट किया
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